Neuropharmacology & Neurotherapeutics
Acupuncture
Sep. 09, 2024
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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The authors discuss the clinical manifestations, etiology, differential diagnosis, diagnostic evaluation, and management of primary cough headache. In this article, studies giving insight into the cause of primary cough headache in patients with or without Chiari I malformations are reviewed. Morphometric MRI studies that have shed new light on the etiology of primary cough headache are summarized, and evidence that CSF leaks may present as cough headache without an orthostatic component is presented. Although indomethacin is typically used to treat primary cough headache, the authors discuss other treatment options, including topiramate.
• Primary cough headache is typically bilateral, of sudden onset, lasts less than 1 minute, and is precipitated rather than aggravated by coughing. | |
• Primary cough headache can be triggered by other sudden Valsalva maneuvers, but it is not typically triggered by sustained physical exercise. | |
• Every patient presenting with cough headache should have an MRI of the brain to rule out a posterior fossa lesion. The MRI should be done with gadolinium looking for pachymeningeal enhancement because headache secondary to spontaneous leak can present as cough headache alone, with no orthostatic component. | |
• Indomethacin is the de facto preventive drug of choice for primary cough headache. |
Headache aggravated or brought on by cough has long been known to be a symptom of intracranial disease (12). This chapter will focus on primary cough headache, which by definition is unassociated with an intracranial disorder (19).
(A) At least two headache episodes fulfilling criteria B-D |
(1) Headache arises moments after the cough or other stimulus.
(2) Headache reaches its peak almost immediately, and then subsides over several seconds to a few minutes (although some patients experience mild to moderate headache for 2 hours).
(3) The syndrome of cough headache is symptomatic in about 40% of cases and the large majority of these represent Chiari type I malformations. Other reported causes of symptomatic cough headache include CSF hypotension, carotid or vertebrobasilar disease, cerebral aneurysms, middle cranial fossa or posterior fossa tumors, midbrain cyst, basilar impression, platybasia, subdural hematoma, and reversible cerebral vasoconstriction syndrome. Diagnostic neuroimaging plays an important role in the search for possible intracranial lesions or abnormalities. Because subtentorial tumors account for more than 50% of intracranial space-occupying lesions in children, cough headache in pediatric patients should be considered symptomatic until proved otherwise.
(A) Either of the following: (1) a single headache episode fulfilling criteria B-D; (2) at least two headache episodes fulfilling criterion B and either of criteria C and D |
Primary cough headache can be triggered by other sudden Valsalva maneuvers but is typically not triggered by sustained physical exercise (37). This is the opposite of the typical circumstance in primary exercise headache.
In 1932, Tinel described four patients with headache brought on by coughing, nose-blowing, breath-holding, and bending the head forward (25). Before Symonds and Rooke’s reports, cough headaches and exertional headaches were always considered ominous symptoms, and there was no clear recognition that benign or primary types of these headaches existed. In 1968, Rooke noted that “in every patient with this complaint, an intracranial lesion of potentially serious nature, such as brain tumor, aneurysm, or vascular anomaly, has been suspected; and even when no such lesion could be identified, an uneasy uncertainty usually has remained" (47).
The landmark paper entitled “Cough Headache” by Sir Charles Symonds brought attention to this disorder (53). Symonds clearly described cases of both secondary and primary cough headache. He presented patients with headache provoked by coughing, and noted that sneezing, straining at stool, laughing, or stooping could also provoke the headache. He did not describe headache precipitated by physical exercise. He outlined the clinical course of primary cough headache and suggested a pathophysiological mechanism for the disorder.
In 1968, Rooke reviewed 93 patients with primary exertional headache (47). He did not separate cough headache from headaches caused by running. However, his data underscored Symonds’ concept that cough headache could be benign.
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MedLink®, LLC
3525 Del Mar Heights Rd, Ste 304
San Diego, CA 92130-2122
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125