Neuro-Ophthalmology & Neuro-Otology
Third nerve palsy
Nov. 22, 2024
Worddefinition
At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas.
Encephalitis lethargica …
- Updated 03.03.2024
- Released 12.08.2006
- Expires For CME 03.03.2027
Encephalitis lethargica
Introduction
Overview
Encephalitis lethargica was a mysterious epidemic disease of the 1920s and 1930s that was better known as the “sleepy” or “sleeping” sickness. Importantly, it was associated with the subsequent development of postencephalitic parkinsonism, a condition that was popularized in Oliver Sacks’ 1973 book, Awakenings, and the 1990 movie of the same name. Encephalitis lethargica evolved to have many manifestations other than a “lethargic type,” including types that were primarily characterized by insomnia or movement disorders. In the acute stage, encephalitis lethargica was characterized by intractable somnolence, which was then attributed to abnormalities of the diencephalon. Since then, anatomical localization of sleep has been focused on the subcortical brain. Differentiating points from idiopathic Parkinson disease include young age of onset, oculogyric crises, altered sleep-wake cycle, respiratory disturbances, and pyramidal signs. A variety of respiratory abnormalities were noted, particularly, unrelenting tachypnoea (panting) without air hunger and an inspiratory hold (fixés en inspiration forcée). These respiratory disorders, in fact, were considered hysterical in nature but later considered serious. Pathologically, there is diffuse involvement of gray matter of the brain dominantly, the diencephalon, and the mesencephalon. There has been extensive debate about the possible role of the “Spanish” H1N1 influenza A pandemic virus in the development of encephalitis lethargica, but this relationship has not yet been established. The role of the substantia nigra and intracellular inclusion bodies (Lewy bodies) in the pathogenesis of idiopathic Parkinson disease was based on observations of severe nigral pathology in encephalitis lethargica. Over a century later, the exact causes of encephalitis lethargica remain unknown, with debates on its autoimmune nature and significant differences between historical and recent cases. No definite treatment for encephalitis lethargica is available. The prognosis is variable. Many of the survivors had permanent neurologic sequelae, and some were completely akinetic.
Key points
|
• Encephalitis lethargica is an acute polio-encephalitis of largely unknown etiology. | |
|
• Encephalitis lethargica can only be diagnosed clinically. | |
|
• Oculogyric crises were not associated with acute cases during the epidemic period. | |
|
• Differentiating points from Parkinson disease are a young age of onset, oculogyric crises, altered sleep cycle, respiratory disturbances, and pyramidal signs. | |
|
• Putative cases have linked the hyperkinetic form of the condition with NMDAR-Ab encephalitis. | |
|
• Although no clear data link encephalitis lethargica with influenza, such a linkage is still supported by some data and some clinicians. |
Historical note and terminology
On April 17, 1917, at a meeting of the Vienna Society for Psychiatry and Neurology, Dr. Constantin von Economo described a new disease, encephalitis lethargica (68). Shortly thereafter, von Economo published his first article on the disease (67). He described a series of cases in which the patients exhibited “a kind of sleeping sickness” with an unusually prolonged course. Headache and malaise were the first symptoms, followed by somnolence, often associated with delirium, from which the patient could be easily awakened. This state could rapidly lead to death or could persist for long periods, either progressing to coma or ending with recovery. These signs were generally accompanied by paralysis in some of the cranial nerves, especially those affecting the eye. Ptosis was a typical sign. Von Economo concluded that he believed the disease was an “encephalitis,” with the variability relating to variations in neural localization of the causative agent.
The disease then began appearing in increasing frequency throughout the world, with official figures showing peaks of about 10,000 cases in 1920 and 1924 (44), with a possible total mortality of 500,000 cases (47) during the entire epidemic period, which lasted until about 1940. Sporadic reports of encephalitis lethargica cases have continued to appear since then.
During the epidemic period, the signs and symptoms of the disease rapidly increased so that eventually 28 “types” were described, with signs and symptoms encompassing virtually every neurologic system (60), including some that were antithetical to von Economo’s original description (eg, an “insomnia” type). Kroker convincingly argued that curing encephalitis lethargica became the foremost aim of American neurology (especially New York City neurologists) during this period and that the secondary goal of this effort was to significantly increase the prominence and potential of American neurology (33). Thus, there may have been some political aspects to the large number of encephalitis lethargica diagnoses. This possible overdiagnosis was also noted during the epidemic period (26).
Wijdicks and Boes studied respiratory rhythm abnormalities reported in patients with epidemic encephalitis (encephalitis lethargica). The authors focused their extensive literature search on disorders of respiration rate, respiratory patterns, and respiratory tics. The respiratory abnormalities most frequently noted included unrelenting tachypnoea (panting) without air hunger and an inspiratory hold (fixés en inspiration forcée). These respiratory disorders, in fact, were previously considered hysterical in nature but later were considered serious. Wijdicks and Boes considered these respiratory disorders part of a parkinsonian syndrome and taught that these attacks could have been provoked by oxygen therapy (69).
Even after 100 years, many issues related to encephalitis lethargica remain elusive. Authors are still struggling to answer the questions: what causes it? How is this disease transmitted? Could an epidemic of encephalitis lethargica happen again? (30; 56). Encephalitis lethargica garnered attention for its impact on consciousness and a potential link to postencephalitic Parkinsonism. Although once considered sporadic, some reviews suggest it might be an autoimmune response to a viral agent, possibly a coronavirus. Historical epidemics like Russian influenza and Spanish flu showed similar neurologic symptoms. Interestingly, some COVID-19 cases present resemblances to encephalitis lethargica (21).
It is now being argued that the crucial involvement of the substantia nigra and the role of intracellular inclusion bodies (Lewy bodies) in the pathogenesis of idiopathic In fact, Parkinson disease may have originated from the finding of dominant nigral pathology in patients with encephalitis lethargica (31).
Clinical manifestations
Presentation and course
Encephalitis lethargica is a highly polymorphic disease that tends to appear in epidemic outbreaks, with signs and symptoms fluctuating to some degree from one epidemic to another. The most common prodromal symptoms are headache, slight sore throat, chilly sensations, general weakness, and mild gastrointestinal disturbances. The most prominent signs are lethargy, sleepiness, or stupor both at the onset and through at least the early stages of the disease. This lethargy may be more apparent than real, however, as the patient is conscious of passing stimuli and, once aroused, immediately becomes alert and sensible (“false sleep” or “pseudo somnolence”). In contrast, the patient may exhibit insomnia, alone or alternating with somnolence. Sometimes, patients exhibit delirium. Paralyses or pareses, most often associated with the cranial nerves, result in oculomotor abnormalities (eg, diplopia, ptosis, accommodation paralysis, sluggish pupils, strabismus, nystagmus), facial paralyses, masticatory paralyses, dysphagia, or dysarthria, and occasionally there are paralyses of the trunk or limbs. Some patients develop parkinsonian rigidity, catatonic stupor, and catalepsy. Other patients show hyperkinetic phenomena, including myoclonias, “fascicular twitchings,” epileptiform convulsions, choreic movements, and maniacal states. Some patients experience sensory disturbances, including pain (eg, headache, facial, muscular). Isolated cases of a cerebellar type of ataxia have been reported. The CSF is generally normal or has a slightly increased cell count (05; 70).
The mortality rates for encephalitis lethargica varied greatly with time and geography. Between 1919 and 1927, in New York City and England, the annual rate varied from 29% to 75%. Although encephalitis lethargica was typically not considered to be contagious, there were some well-researched instances in which the condition did appear to spread from person to person (58).
Encephalitis lethargica could also be complicated by severe changes in behavior, particularly in children.
Von Economo said of children with encephalitic lethargica in his 1931 monograph, “We see here how organic encephalitic lesions may produce in previously normal individuals a strange alteration of personality, which cannot be otherwise described than as a kind of moral insanity or erethic imbecility.” Von Economo continued to note that these children “annoy strangers on the street, pluck their clothing, make faces at them or abuse them; they tramp, beg, lie, steal, write on the walls, squander all the money they can lay hands on in sweets, cannot be controlled at school, run away from home and spend their time at the cinema and in the streets, indulge in sexual misbehaviour of every kind and make other dangerous acts” (68). Except in the very young, there was no deterioration of intellect (10). The pejorative term “Apache” was used to characterize these children, referring to the wild behavior attributed to Apache Indians (26). Hill estimated that, whereas 70% of pediatric encephalitic lethargica survivors showed some psychological changes, approximately one third exhibited behavioral disorders (28). In the acute phase, encephalitis lethargica was characterized by intractable somnolence, which was then attributed to abnormalities of the diencephalon. This indicated that sleep mechanisms are localized in the subcortical brain (37).
Encephalitis lethargica was often complicated by lingering or permanent somatic or psychological sequelae, the most serious of which was postencephalitic parkinsonism (22). Postencephalitic parkinsonism could develop within a short time of the original episode, after a number of symptomatic changes, or even months or years (in some cases many years) after symptoms have purportedly disappeared. The hallmark features of postencephalitic parkinsonism comprise rigidity, tremor, dysarthria, flexed postures, and masked facies (70). The best differentiators of postencephalitic parkinsonism from idiopathic parkinsonism are onset below middle age, symptoms lasting more than 10 years, presence of oculogyric crises, and palilalia (29; 34).
Other features that Hoehn and Yahr considered uncommon in the idiopathic form but common in postencephalitic parkinsonism include oculomotor and other cranial nerve palsies, pyramidal tract signs, dystonic phenomena, sleep disturbances, personality changes, and autonomic dysfunction (29).
The presumptive direct relationship between encephalitis lethargica and postencephalitic parkinsonism has been questioned (58; 59). These authors noted that careful analysis of the historical data indicated that many (perhaps, the majority) of persons with postencephalitic parkinsonism did not have a prior well-defined encephalitic disease but often had had a condition (eg, influenza) that was diagnosed post hoc as encephalitis lethargica. Based on these data, it has been thought that the relationship between encephalitis lethargica and parkinsonism is more complex than perceived, ie, that encephalitis lethargica alone was not responsible for the subsequent development of parkinsonism.
Prognosis and complications
Whereas some patients appear to show a complete recovery, others show persisting somatic impairments (eg, movement disorders) or psychological impairments (eg, behavioral disorders, especially in children). Postencephalitic parkinsonism was believed to be a sequel in up to 80% of affected individuals (22).
Clinical vignette
One of the most well-known cases of encephalitis lethargica was that of Patricia Maguire, who was also known as Oak Park’s (Illinois) “sleeping beauty.” In January 1932, 27-year-old Patricia began feeling increasingly drowsy each day. After falling asleep on a train, she returned home and slumbered fitfully for 9 days and then, on February 24, became comatose. After about a year and a half, she began to show signs of consciousness with open eyes, alert expressions, and the ability to respond to simple commands, although her eyes did not respond to light, and she could not speak. Unfortunately, these positive signs did not last, and she again became comatose. Maguire died of pneumonia in 1937. Her brain was removed after death and revealed an atrophied frontal lobe, which was believed to confirm a diagnosis of encephalitis lethargica.
Although no good images of Patricia Maguire are available, there are many still and moving images of patients with encephalitis lethargica (64). German neuropsychiatrists Karl Kleist and Ernst Herz made a detailed film (13 minutes) of one young patient, and a segment of that film is available here.
Biological basis
Etiology and pathogenesis
At the time of the epidemic, various bacterial or viral causes were proposed for the condition, but no definitive findings were reached. There has been extensive debate about a possible role of the “Spanish” H1N1 influenza A pandemic virus in the development of encephalitis lethargica (52). Modern efforts to demonstrate influenza RNA segments in the brains of encephalitis lethargica victims, however, have not been successful (39; 35). Nevertheless, these results are far from conclusive, so there remains a possibility that a recurrence of bird-based influenza will result in a recurrence of encephalitis lethargica (40; 38), which advocates that influenza did cause encephalitis lethargica. Foley exhaustively examined the historical record pertaining to the relationship between encephalitis lethargica and influenza and concluded that, whereas any individual feature of encephalitis lethargica could be found in influenza, the combination of symptoms was unique, suggesting that encephalitis lethargica was not likely caused by influenza (24; 25; 19).
Although a viral etiology has always been suspected in postencephalitic parkinsonism, no definitive infectious agent has been isolated. Several case reports suggested that infection with atypical enterovirus can result in postencephalitic parkinsonism and a picture similar to encephalitis lethargica (01; 53). Evidence for encephalitis lethargica's autoimmune nature is also limited, suggesting it may have been a unique response to an unknown pathogen in genetically susceptible individuals. Contemporary autoimmune encephalomyelitis cases, though increasing, differ significantly from historical encephalitis lethargica in symptoms, epidemiology, and pathology (12).
In three cases, parkinsonism has been described following SARS-COV-19 infection. In these cases, a viral invasion of the brainstem, in these cases, has been speculated (14; 23; 42). However, the possibility of SARS-CoV-2 causing an encephalitis lethargica-like state remains speculative (04; 27). Morassi and colleagues described two isolated cases of SARS-CoV-2-related encephalitis with prominent parkinsonism (43). FDG-PET/CT findings in these patients were consistent with postencephalitic parkinsonism. FDG-PET/CT demonstrated the presence of cortical hypometabolism along with hypermetabolism in the regions of the brainstem, mesial temporal lobes, and basal ganglia.
Dale and colleagues attempted to determine the cause of encephalitis lethargica by identifying 20 new cases of encephalitis lethargica in England between 1999 and 2002; 11 of the patients had preceding pharyngitis (16). They then investigated the possibility that the patients’ phenotype could be a postinfectious autoimmune CNS disorder, similar in that respect to Sydenham chorea. Western immunoblotting showed that 19 of the patients had autoantibodies reactive against human basal ganglia antigens. The authors concluded that an encephalitis lethargica-like syndrome is still prevalent and that encephalitis lethargica may be secondary to autoimmunity against deep gray matter neurons resulting from a prior group A Streptococcus infection (ie, a PANDAS disease) (16). The conclusions of Dale and colleagues were then questioned in a 2004 editorial in Brain, which noted that only a minority of the cases had two of the more diagnostic signs of encephalitis lethargica: ophthalmoplegia and oculogyric crises (66). Additional criticism can be found in a study by Singer and colleagues, who took serum from patients in three groups (patients with PANDAS, patients with Tourette syndrome, and age-matched controls). ELISA and Western blots against crude soluble extracts of postmortem brain regions and Western blots against putative antigens were performed. Antibodies were found for all groups, but there were no differences in antibody frequencies between patient groups and controls (48). According to Vernino, these results cast doubt on the role of neurologic antibodies in these pediatric neuropsychiatric movement disorders but do not exclude an immune-mediated (or even antibody-mediated) etiology for these diseases (and presumably for encephalitis lethargica) (57).
In a report, Dale and colleagues seemed to rescind the PANDA theory and suggested instead that at least the dyskinetic form of encephalitis lethargica may be due to the development of autoantibodies to the extracellular domain of NR1/NR2 subunits of the N-methyl-D-aspartate receptor (NMDAR-Ab) (17). Sera from 10 of 20 pediatric patients with putative encephalitis lethargica was found to be NMDAR-Ab positive with dyskinesias, insomnia, and seizures. The authors referred to studies that have identified encephalitis lethargica-like features in young females with ovarian teratomas who also were serum and CSF positive for NMDAR-Ab. They concluded that the dyskinetic (hyperkinetic) form of encephalitis lethargica is an NMDAR-Ab encephalitis that can affect very young children.
It is unclear whether the findings of Dale and colleagues (17) mean that the different forms of encephalitis lethargica had different etiologies (eg, the dyskinetic form had a different cause than the lethargic form), a hypothesis supported in a book about encephalitis lethargica (59). Since the 2009 report by Dale and colleagues, other case studies have appeared supporting a relationship between the dyskinetic (hyperkinetic) form of encephalitis lethargica and NMDAR-Ab encephalitis (45; 51).
This summary of the pathology of encephalitis lethargica is based primarily on the 1921 review of encephalitis lethargica by CP Symonds, a prominent British neurologist (50). The described pathology is only for encephalitis lethargica; the pathology associated with postencephalitic parkinsonism is not described here; for that, see (54; 32).
The gross fresh brain of an encephalitis lethargica victim shows little abnormality beyond congestion of the meningeal and intracerebral capillaries. This congestion causes the brain to be reddish in color in cross-section, and the cut vessels are widely open and oozing bright blood.
Microscopic examination of the preserved brain indicates that the most important features are vascular congestion, signs of toxic degeneration of neurons and neuronophagia, proliferation of vessel wall cells, infiltration of the perivascular (Virchow-Robin) spaces with small round cells, and glial proliferation. Degenerative loss of neurons in nuclei is variable; when present, the degenerating cells exhibit swelling and eccentricity of the nucleus, chromatolysis, and neuronophagia.
Symonds stressed that the brain of a patient who dies rapidly from encephalitis lethargica might show little pathology, perhaps only vascular congestion. Symonds accounted for this observation by noting that cellular function may be lost before any visible structural alterations. He also reported that the distribution of lesions varies greatly from patient to patient, although more lesions appear within the midbrain and basal ganglia than elsewhere. Others, however, indicated that cortical damage was frequent and basal ganglia damage rather infrequent (06). Our own analysis of 112 acute cases from the epidemic period suggests that about 80% showed cortical damage, whereas only about 40% showed basal ganglia damage (03).
Epidemiology
Encephalitis lethargica was a widespread pandemic disease during the 1920s and into the 1930s. It may have lasted until the 1950s in the Soviet Union (65). Sporadic case reports continue to appear (16; 20; 41; 49; 11; 18; 46; 02; 55), although there is no assurance that these modern cases are, in fact, identical to the 1920s era cases.
Prevention
No information is available regarding the prevention of encephalitis lethargica. If encephalitis lethargica results from bird influenza, immunization against bird influenza could be preventative for encephalitis lethargica.
Differential diagnosis
Confusing conditions
Encephalitis lethargica was diagnosed based on the exclusion of other known neurologic diseases (see Table 1). Crafts wrote, “And while no other disease, perhaps, presents so many difficulties in diagnosis as does this protean complex…that while it usually offers very close resemblance to one or another condition, careful and painstaking study and comparison will reveal either some incongruity; some essential symptom lacking or a superabundance of elements, thus, offering a definite aid or conclusive basis for differential diagnosis” (15). Unfortunately, because encephalitis lethargica lacked any definitive sign, it is possible and perhaps likely that it was substantially overdiagnosed (26). This absence would also account for the abundance of “types” that came to be associated with the disease (60).
Oculogyric crises are also often cited in case reports of the disease, but this sign was not associated with the acute condition during the epidemic period; these crises are, however, associated with its presumptive sequel, postencephalitic parkinsonism (61).
Table 1. Diagnostic Criteria of Encephalitis Lethargica
|
(1) Recent influenza-like manifestations (07) | |
|
• Ptosis | |
|
(5) Psychiatric changes | |
Diagnostic workup
There are no diagnostic tests for encephalitis lethargica, so it remains a clinical diagnosis.
In two cases, MRI of the brain revealed signal abnormalities in the substantia nigra, thalamus, and hippocampus. Extensive subcortical white matter abnormalities in the frontal lobes have also been described in a case (71; 13).
Management
During the epidemic period, many different treatments for encephalitis lethargica were used, and in New York, a large-scale effort supervised by the Matheson Commission was devoted to developing a vaccine to treat the disease (36). None of the treatments or vaccines proved to be efficacious. In 1997, two cases of the disease were described as responding rapidly and dramatically to intravenous methylprednisone (09). Other treatments include antibiotics, intravenous immunoglobulin therapy, and electroconvulsive therapy (18; 46; 02; 71; 13). In an isolated case report, a patient with postencephalitic parkinsonism, a disorder very close to encephalitis lethargica, responded well to a levodopa and carbidopa combination (08).
Special considerations
Pregnancy
There have been cases of the disease apparently passing from mother to newborn infant.
Media
References
- 01
- Akcakaya NH, Tekturk P, Cagatay A, Tur EK, Yapici Z. Atypical enterovirus encephalitis causing behavioral changes and autism-like clinical manifestations: case report. Acta Neurol Belg 2016;116(4):679-81. PMID 26895551
- 02
- Ali S, Welch CA, Park LT, et al. Encephalitis and catatonia treated with ECT. Cogn Behav Neurol 2008;21(1):46-51. PMID 18327024
- 03
- Anderson LL, Vilensky JA, Duvoisin RC. Neuropathology of acute encephalitis lethargica: a review of cases from the epidemic period. Neuropath Appl Neurobiol 2009;35:462-72. PMID 19490429
- 04
- Badrfam R, Zandifar A. From encephalitis lethargica to COVID-19: Is there another epidemic ahead? Clin Neurol Neurosurg 2020;196:106065. PMID 32659638
- 05
- Barker LF. Diagnostic criteria in epidemic encephalitis and encephalomyelitis. Arch Neurol Psych 1921;5:173-96.
- 06
- Bassoe P. Delirious and meningoradicular types of epidemic encephalitis. JAMA 1920;74:1009-12.
- 07
- Berger JR, Vilensky JA. Encephalitis lethargica (von Economo's encephalitis). Handb Clin Neurol 2014;123:745-61. PMID 25015515
- 08
- Bigman DY, Bobrin BD. Von Economo's disease and postencephalitic parkinsonism responsive to carbidopa and levodopa. Neuropsychiatr Dis Treat 2018;14:927-31. PMID 29670352
- 09
- Blunt SB, Lane RJ, Turjanski N, Perkin GD. Clinical features and management of two cases of encephalitis lethargica. Mov Disord 1997;12(3):354-9. PMID 9159730
- 10
- Bond ED, Appel KE. The Treatment of Behavior Disorders Following Encephalitis. New York: The Commonwealth Fund, 1931.
- 11
- Brenneis C, Scherfler C, Engelhardt K, et al. Encephalitis lethargica following Bartonella henselae infection. J Neurol 2007;254(4)546-7. PMID 17351727
- 12
- Brigo F, Vogrig A. Back to the future: encephalitis lethargica as an autoimmune disorder? Neurol Sci 2024;45(1):93-9. PMID 37688743
- 13
- Brunetti V, Testani E, Iorio R, et al. Post-encephalitic parkinsonism and sleep disorder responsive to immunological treatment: a case report. Clin EEG Neurosci 2016;47(4):324-9. PMID 27118763
- 14
- Cohen ME, Eichel R, Steiner-Birmanns B, et al. A case of probable Parkinson's disease after SARS-CoV-2 infection. Lancet Neurol 2020;19(10):804-5. PMID 32949534
- 15
- Crafts LM. Epidemic Encephalitis (Encephalo-Myelitis). Boston: Richard G. Badger, 1927.
- 16
- Dale RC, Church AJ, Surtees RA, et al. Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Brain 2004;127(Pt 1):21-33. PMID 14570817
- 17
- Dale RC, Irani SR, Brilot F, et al. N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica. Ann Neurol 2009;66(5):704-9. PMID 19938173
- 18
- Dale RC, Webster R, Gill D. Contemporary encephalitis lethargica presenting with agitated catatonia, stereotypy, and dystonia-parkinsonism. Mov Disord 2007;22(15):2281-4. PMID 17914719
- 19
- Davis LE, Koster F, Cawthon A. Neurologic aspects of influenza viruses. Handb Clin Neurol 2014;123:619-45. PMID 25015508
- 20
- Dewar BK, Wilson BA. Cognitive recovery from encephalitis lethargica. Brain Inj 2005;19(14):1285-91. PMID 16286345
- 21
- Di Vito A, Donato A, Bria J, Donato F, Donato G. Encephalitis lethargica. What is still wrong? Int J Immunopathol Pharmacol 2023;37:3946320231154997. PMID 36716496
- 22
- Duvoisin RC, Yahr MD. Encephalitis and parkinsonism. Arch Neurol 1965;12:227-39. PMID 14247380
- 23
- Faber I, Brandão PRP, Menegatti F, Bispo DDC, Maluf FB, Cardoso F. Coronavirus disease 2019 and parkinsonism: a non-post-encephalitic case. Mov Disord 2020;35(10):1721-2. PMID 32815213
- 24
- Foley PB. Encephalitis lethargica and the influenza virus. II. The influenza pandemic of 1918/19 and encephalitis lethargica: epidemiology and symptoms. J Neural Transm 2009a;116:1295-1308. PMID 19707848
- 25
- Foley PB. Encephalitis lethargica and the influenza virus. III. The influenza pandemic of 1918/19 and encephalitis lethargica: neuropathology and discussion. J Neural Transm 2009b;116:1309-21. PMID 19707847
- 26
- Ford FR. Diseases of the nervous system: in infancy, childhood and adolescence. Springfield, Illinois: Charles C. Thomas, 1937.
- 27
- Giordano A, Schwarz G, Cacciaguerra L, Esposito F, Filippi M. COVID-19: can we learn from encephalitis lethargica? Lancet Neurol 2020;19(7):570. PMID 32562680
- 28
- Hill TR. Problem of juvenile behaviour disorders in chronic epidemic encephalitis. J Neurol Psychopathol 1928;9(33):1-10. PMID 21611262
- 29
- Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17(5):427-42. PMID 6067254
- 30
- Hoffman LA, Vilensky JA. Encephalitis lethargica: 100 years after the epidemic. Brain 2017;140(8):2246-51. PMID 28899018
- 31
- Holdorff B. Centenary of Tretiakoff's thesis on the morphology of Parkinson's disease, evolved on the grounds of encephalitis lethargica pathology. J Hist Neurosci 2019;28(4):387-98. PMID 31226240
- 32
- Ishii T, Nakamura Y. Distribution and ultrastructure of Alzheimer’s neurofibrillary tangles in postencephalitic Parkinsonism of Economo type. Acta Neuropathol (Berl) 1981;55(1):59-62. PMID 7348007
- 33
- Kroker K. Epidemic encephalitis and American neurology, 1919-1940. Bull Hist Med 2004;78(1):108-47. PMID 15161088
- 34
- Litvan I I, Jankovic J, Goetz CG, et al. Accuracy of the clinical diagnosis of postencephalitic parkinsonism: a clinicopathologic study. Eur J Neurol 1998;5(5):451-7. PMID 10210873
- 35
- Lo KC, Geddes JF, Daniels RS, Oxford JS. Lack of detection of influenza genes in archived formalin-fixed, paraffin wax-embedded brain samples of encephalitis lethargica patients from 1916 to 1920. Virchows Arch 2003;442(6):591-6. PMID 12695912
- 36
- Louis ED. Vaccines to treat encephalitis lethargica: human experiments at the Neurological Institute of New York, 1929-1940. Arch Neurol 2002;59(9):1486-90. PMID 12223039
- 37
- Lutters B, Foley P, Koehler PJ. The centennial lesson of encephalitis lethargica. Neurology 2018;90(12):563-7. PMID 29555881
- 38
- Maurizi CP. Influenza caused epidemic encephalitis (encephalitis lethargica): the circumstantial evidence and a challenge to the nonbelievers. Med Hypoth 2010;74:798-801. PMID 20060230
- 39
- McCall S, Henry JM, Reid AH, Taubenberger JK. Influenza RNA not detected in archival brain tissues from acute encephalitis lethargica cases or in postencephalitic Parkinson cases. J Neuropathol Exp Neurol 2001;60(7):696-704. PMID 11444798
- 40
- McCall S, Vilensky JA, Gilman S, Taubenberger JK. The relationship between encephalitis lethargica and influenza: a critical analysis. J Neurovirol 2008;14(3):177-85. PMID 18569452
- 41
- McKee DH, Sussman JD. Case report: severe acute Parkinsonism associated with streptococcal infection and antibasal ganglia antibodies. Mov Disord 2005;20(12):1661-3. PMID 16078204
- 42
- Mendez-Guerrero A, Laespada-García MI, Gómez-Grande A, et al. Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection. Neurology 2020;95(15):e2109-18. PMID 32641525
- 43
- Morassi M, Palmerini F, Nici S, et al. SARS-CoV-2-related encephalitis with prominent parkinsonism: clinical and FDG-PET correlates in two patients. J Neurol 2021;268(11):3980-7. PMID 33884450
- 44
- Neal J, editor. Epidemic encephalitis: etiology, epidemiology, treatment. Report of a survey by the Matheson Commission. New York: Columbia University Press, 1929.
- 45
- Poloni C, Korff CM, Ricotti V, et al. Severe childhood encephalopathy with dyskinesia and prolonged cognitive disturbances: evidence for anti-N-methyl-D-aspartate receptor encephalitis. Dev Med Child Neurol 2010;52:e78-82. PMID 20041934
- 46
- Raghav S, Seneviratne J, McKelvie PA, Chapman C, Talman PS, Kempster PA. Sporadic encephalitic lethargica. J Clin Neurosci 2007;14(7):696-700. PMID 16647855
- 47
- Ravenholt RT, Foege WH. 1918 influenza, encephalitis lethargica, parkinsonism. Lancet 1982;2(8303):860-4. PMID 6126720
- 48
- Singer HS, Hong JJ, Yoon D, Williams PN. Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. Neurology 2005;65:1701-7. PMID 16207842
- 49
- Sridam N, Phanthumchinda K. Encephalitis lethargica like illness: case report and literature review. J Med Assoc Thai 2006;89(9):1521-7. PMID 17100395
- 50
- Symonds CP. Critical review: encephalitis lethargica. Quart J Med 1921;14:283-308.
- 51
- Tan A, Shuey N, Bladin C. A modern perspective on the differential diagnosis between encephalitis lethargica or anti-NMDA-receptor encephalitis. J Clin Neurosci 2010;1204-6. PMID 20605463
- 52
- Tappe D, Alquezar-Planas DE. Medical and molecular perspectives into a forgotten epidemic: encephalitis lethargica, viruses, and high-throughput sequencing. J Clin Virol 2014;61(2):189-95. PMID 25129855
- 53
- Toledano M, Davies NW. Enteroviral postencephalitic parkinsonism with evidence of impaired presynaptic dopaminergic function. JAMA Neurol 2016;73(8):1023-5. PMID 27367905
- 54
- Torvik A, Meen D. Distribution of the brain stem lesions in postencephalitic Parkinsonism. Acta Neurol Scand 1966;42(4):415-25. PMID 5919815
- 55
- van Toorn R, Schoeman JF. Encephalitis lethargica in five South African children. Eur J Paediatr Neurol 2009;13(1):41-6. PMID 18424201
- 56
- Venegas-Francke P. Encephalitis lethargica. The epidemic at the dawn of neurology [Article in Spanish]. Rev Neurol 2019;68(2):82-8. PMID 30638258
- 57
- Vernino S. Neurologic autoantibodies. Neurology 2005;65:1688-9. PMID 16344507
- 58
- Vilensky JA. Transmissibility (contagiousness) of encephalitis lethargica. In: Vilensky JA, editor. Encephalitis Lethargica: During and After the Epidemic. New York: Oxford University Press, 2010a.
- 59
- Vilensky JA. Encephalitis Lethargica: During and After the Epidemic. New York: Oxford University Press, 2010b.
- 60
- Vilensky JA, Gilman S. Encephalitis lethargica: could this disease be recognised if the epidemic recurred. Pract Neurol 2006;6:360-7.
- 61
- Vilensky JA, Gilman S, Duvoisin RC, Mukhamedzyanov RZ. Post-epidemic period encephalitis lethargica. In: Vilensky JA, editor. Encephalitis Lethargica: During and After the Epidemic. New York: Oxford University Press, 2010c.
- 62
- Vilensky JA, Gilman S, McCall S. Does the historical literature on encephalitis lethargica support a simple (direct) relationship with postencephalitic Parkinsonism. Mov Disord 2010a;25(9):1124-30. PMID 20629127
- 63
- Vilensky JA, Gilman S, McCall S. A historical analysis of the relationship between encephalitis lethargica and postencephalitic parkinsonism: a complex rather than a direct relationship. Mov Disord 2010b;25(9):1116-23. PMID 20629120
- 64
- Vilensky JA, Goetz CG, Gilman S. Movement disorders associated with encephalitis lethargica: a video compilation. Mov Disord 2006;21(1):1-8. PMID 16200538
- 65
- Vilensky J, Mukhamedzyanov R, Gilman S. Encephalitis lethargica in the Soviet Union. Eur Neurol 2008;60(3):113-21. PMID 18628628
- 66
- Vincent A. Encephalitis lethargica: part of a spectrum of post-streptococcal autoimmune diseases. Brain 2004;127(Pt 1):2-3. PMID 14679031
- 67
- von Economo C. Encephalitis lethargica. Wien Klin Wochenschr 1917;30:581-5.
- 68
- von Economo C. Encephalitis lethargica: its sequelae and treatment. London: Oxford University Press, 1931.
- 69
- Wijdicks E, Boes CJ. On respiratory crisis and other respiratory curiosities in the aftermath of encephalitis lethargica: "like asthma." Neurology 2022:10.1212/WNL.0000000000200800. PMID 35613934
- 70
- Wilson SAK. Neurology. Baltimore: The Williams & Wilkins Company, 1940.
- 71
- Yang L, Jia G, Li B, Lei G, Sun R. Encephalitis lethargica with isolated substantia nigra lesions followed by a second encephalitis in a child with humoral immunodeficiency. Pediatr Neurol 2015;53(6):519-22. PMID 26431898
Contributors
All contributors' financial relationships have been reviewed and mitigated to ensure that this and every other article is free from commercial bias.
Author
-
Ravindra Kumar Garg DM FRCP
Dr. Garg of King George's Medical University in Lucknow, India, has no relevant financial relationships to disclose.
See Profile
Editor
-
John E Greenlee MD
Dr. Greenlee of the University of Utah School of Medicine has no relevant financial relationships to disclose.
See Profile
Former Authors
- Joel A Vilensky PhD
Patient Profile
- Age range of presentation
-
- 0 month to 65+ years
- Sex preponderance
-
- male>female, >1:1
- Heredity
-
- none
- Population groups selectively affected
-
- none selectively affected
- Occupation groups selectively affected
-
- none selectively affected
ICD & OMIM codes
- ICD-9
-
- Other specified non-arthropod-borne viral diseases of central nervous system: 049.8
- ICD-10
-
- Other specified viral encephalitis: A85.8
This is an article preview.
Start a Free Account
to access the full version.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Questions or Comment?
MedLink®, LLC
3525 Del Mar Heights Rd, Ste 304
San Diego, CA 92130-2122
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
Also in This Category
-
-
Neuro-Ophthalmology & Neuro-Otology
Nystagmus
Nov. 22, 2024
-
Peripheral Neuropathies
Neuropathies associated with cytomegalovirus infection
Nov. 16, 2024
-
Infectious Disorders
Genital herpes: neurologic complications
Nov. 15, 2024
-
Infectious Disorders
Neurocysticercosis
Nov. 12, 2024
-
General Neurology
Brain death/death by neurologic criteria
Nov. 09, 2024
-
General Neurology
Hepatic encephalopathy
Oct. 23, 2024
-
General Neurology
Cervical spondylotic myelopathy
Oct. 11, 2024