Cerebral venous thrombosis in infants and children …

General Child Neurology

Updated 03.29.2024
Released 02.03.1994
Expires For CME 03.29.2027

Cerebral venous thrombosis in infants and children

Authors: Mahendranath D Moharir MD MSc, Samyami Chowdhury BSc(hons) MBChB MRCPCH

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Editor: Bernard L Maria MD

Cerebral venous thrombosis in infants and children

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Introduction

Overview

Cerebral sinovenous thrombosis is often unrecognized in neonates and children due to nonspecific clinical features and challenges in radiographic diagnosis. Risk factors for cerebral sinovenous thrombosis in neonates are different from those in older children. Treatment with anticoagulants, a well-established practice in adults, is increasingly offered in children and, to a lesser extent, in neonates. The safety of anticoagulants and recanalization outcomes in cerebral sinovenous thrombosis has been established in children as well as in neonates based on consecutive cohort studies; however, its benefit on neurologic outcome, particularly in neonates, has not been proven. The clinical outcome from cerebral sinovenous thrombosis remains worse in neonates than in children.

Key points

	• The clinical and radiographic diagnosis of cerebral sinovenous thrombosis is challenging in neonates and children.
	• Cerebral sinovenous thrombosis should be considered in any child with unexplained seizures and/or encephalopathy.
	• Anticoagulant therapy is safe in the absence of significant intracranial hemorrhage in neonates and children. It is probably safe in the presence of intracranial hemorrhage as well, at least in older children.
	• Anticoagulant therapy prevents worsening of thrombosis in both neonates and children.
	• Clinical outcomes are poor in the majority of neonates with cerebral sinovenous thrombosis.

Historical note and terminology

Early literature on cerebral sinovenous thrombosis is mainly based on autopsy studies by French physicians. In 1873, Parrot recognized sagittal sinus thrombosis in neonates. In 1884, Bouchut observed cerebral sinovenous thrombosis in infants who had seizures during febrile or debilitating illnesses. The same year, Rilliet and Barthez reported infection as a predisposing factor in young children. Lhermitte described the association of cerebral sinovenous thrombosis with congenital heart disease. Several years later, Symonds described “otitic hydrocephalus” referring to hydrocephalus and raised intracranial pressure in children with chronic otitis media and mastoiditis (74). This probably represents the first description of childhood cerebral sinovenous thrombosis in modern English literature. Because the condition was considered infrequent and difficult to diagnose, systematic literature was rare before the advent of modern neuroimaging techniques.

Clinical manifestations

Presentation and course

The clinical features of cerebral sinovenous thrombosis can be subtle and diffuse. They are dependent on the child’s age, extent, and location of thrombosis, along with presence/absence of associated venous infarction. In young children, coexisting neurologic diseases produce neurologic signs that overshadow or are impossible to differentiate from those of cerebral sinovenous thrombosis. Seizures and encephalopathy of varying degrees still remain the major presenting feature in both neonates (72% and 60%, respectively) and children (50% and 25%, respectively) (17; 66; 55; 52; 33). Raised intracranial pressure develops gradually over hours, days, and sometimes weeks. In neonates and infants, a tense anterior fontanelle, separation of skull sutures, and dilated scalp veins may be seen. Focal neurologic deficits are rare in neonates (17; 55). In older infants and children, signs of raised intracranial pressure-like headache and papilledema with false localizing sixth cranial nerve palsy predominate with associated varying levels of altered consciousness. Seizures are present in about 50% of children (17) and are more frequently reported in patients with thrombosis of cortical veins (63). Headache and papilledema secondary to cerebral sinovenous thrombosis usually cannot be differentiated from that due to idiopathic intracranial hypertension. Visual disturbances are reported in about 20% of children and consist chiefly of diplopia due to false localizing sixth nerve palsy and visual field abnormalities.

Prognosis and complications

The main complications of cerebral sinovenous thrombosis in children are intracranial hemorrhage and raised intracranial pressure that influence short-term mortality and long-term morbidity. A major difficulty in studying predictors of recanalization or long-term clinical outcome is the influence of coexisting neurologic conditions that are present in a large number of children, especially neonates, with cerebral sinovenous thrombosis. Mortality in children is comparable to adults with cerebral sinovenous thrombosis ranging from 10% to 20%. Children in general tend to do better than neonates (52). The frequency of adverse neurologic outcomes in older children ranges from 10% to 20% (31; 52) whereas in neonates it ranges from 40% to 80% (27; 04; 52; 51; 37). Epilepsy is reported in 10% to 25% in survivors (52; 49). The range of neurologic abnormalities includes deficits in sensorimotor, language, and cognitive and behavioral domains. Recanalization rates and outcomes in neonates and children have now been documented (52). Neonates recanalize their thrombus faster (by 3 months) than older children (by 6 months). The findings in older children are similar to adults (05). The influence of recanalization on clinical outcome is less clear in all age groups, because in adults the data are conflicting (73; 72), and in the pediatric age group, neonates who recanalize earlier and more completely than older children still have a worse clinical outcome (52). We speculate that perhaps it is the rate of recanalization rather than the final outcome of recanalization that might matter. Recurrence of cerebral sinovenous thrombosis has not been reported in neonates and appears to be rare. In older children, recurrence rates, mainly determined by the presence of a prothrombotic state, range from 10% to 15% (35).

Clinical vignette

A 2.6-kg male term newborn was born to a 28-year-old Guillain Barré (group B streptococcus)-positive mother following normal pregnancy and delivery. He was transferred from nursery to NICU and ventilated as he became lethargic with apneic spells, abdominal distension, and no meconium passage for 24 hours. He was started on ampicillin, tobramycin, and metronidazole and loaded with phenobarbitone. Nasogastric aspirate returned bloody aspirate. Abdominal x-ray and ultrasound showed distended bowel loops. Peripheral white blood cell count and C-reactive protein were elevated. He underwent exploratory laparotomy with appendicectomy and colostomy. Parenteral nutrition was started postoperatively. Toxic megacolon diagnosis was made following positive blood culture for E coli. Ceftriaxone and vancomycin were added. Ampicillin and tobramycin were discontinued. Metronidazole was continued. CSF was normal. Post-op head ultrasound showed small bilateral germinal matrix hemorrhage. Contrast head CT revealed extensive thrombus in superior sagittal, torcular, and transverse sinuses and mild diffuse cerebral edema but no hemorrhage. Cerebral sinovenous thrombosis was diagnosed. Unfractionated heparin was started. EEG revealed mild excess of multifocal sharp waves and discontinuity. MRI the next day confirmed CT findings and in addition revealed bilateral deep white matter tiny petechial hemorrhages. Plain head CT after 3 days of heparin, performed to rule out major hemorrhagic complication on heparin, was unremarkable. Surgical site and abdominal ultrasound did not reveal bleeding. Treatment was switched over to low-molecular-weight heparin. Meanwhile, clinically the newborn improved with no further apneic spells or seizures. Antibiotics were stopped after 2 weeks. Repeat EEG on day 7 was normal. Gradual oral feeds were resumed. Bowel issues resolved. He was discharged well on low-molecular-weight heparin after 3 weeks. A follow-up CT venogram at 6 weeks revealed partial recanalization of the thrombus. At 3 months, full recanalization occurred and low-molecular-weight heparin was stopped. Neurologic follow-up at 2 years was normal. He continued to follow up with gastroenterology services for his bowel issues.

Biological basis

Etiology and pathogenesis

Cerebral sinovenous thrombosis results from a combination of intravascular and vascular risk factors. Prothrombotic states may predispose directly to thrombosis whereas acute and chronic illnesses or prothrombotic medications act as triggers. Idiopathic cerebral sinovenous thrombosis is reported in less than 10% to 15% of children (52). Neonates are vulnerable to cerebral sinovenous thrombosis due to many physiological risk factors. These are pregnancy- and perinatal period-related maternal hypercoagulable state (03), molding of skull bones during labor causing mechanical damage to underlying dural sinuses, a relatively high hematocrit, venous flow that is dependent on head positioning (14), and lower than normal levels of fibrinolytic factors like protein C, protein S, and antithrombin III (02). Physiological compression of the superior sagittal sinus by the occipital bone in supine position has been implicated as a potential mechanism for cerebral sinovenous thrombosis in neonates (75). Prenatal or perinatal disorders have been reported in approximately 51% of neonates with cerebral sinovenous thrombosis. These include maternal infections, gestational diabetes, premature rupture of membranes, abruptio placentae, and birth asphyxia (82). Preterm birth and complicated delivery are also risk factors for cerebral sinovenous thrombosis. Hypoxia in the preterm is an independent risk factor associated with neonatal cerebral sinovenous thrombosis (70). Other acquired insults include dehydration, bacterial sepsis, and meningitis. Hypernatremic dehydration in exclusively breastfed neonates has been associated with neonatal cerebral sinovenous thrombosis (69). A 27% (10 out of 37) incidence of cerebral sinovenous thrombosis secondary to posttherapeutic hypothermia for asphyxia has been shown (60). Post cardiac surgery, there was found to be a 28% (11 out of 40) incidence of neonatal cerebral sinovenous thrombosis (13). Associated risk factors included younger age, lower weight, and the use of central venous catheter. Prothrombotic abnormalities have been reported in 15% to 20% of neonates with cerebral sinovenous thrombosis (08). In older infants, iron deficiency anemia is occasionally associated with cerebral sinovenous thrombosis (66). Head and neck infections, especially otitis media and mastoiditis, resulting in septic cerebral sinovenous thrombosis are present in 25% of older infants and children (17; 33). In older children, head trauma or cranial surgery can mechanically damage dural sinuses and cause cerebral sinovenous thrombosis (64; 84). Chronic systemic diseases that result in an acquired prothrombotic state are present in about 60%. These include systemic lupus erythematosus, nephrotic syndrome, inflammatory bowel disease, hematologic disorders, cardiac disease, and others (17; 62). Acute illnesses with accompanying element of dehydration are present in nearly one third of children with cerebral sinovenous thrombosis. Acquired and congenital prothrombotic abnormalities put together have been reported in 33% to 96% of children with cerebral sinovenous thrombosis (08). Congenital prothrombotic disorders include factor V Leiden; prothrombin gene G20210A; dysfibrinogenemia; deficiencies of protein C, protein S, and antithrombin III; factor VIII, factor IX, and factor XI excess; factor XII deficiency; and thrombomodulin mutation (16; 08; 41). Acquired prothrombotic states include anticardiolipin antibody; lupus anticoagulant; acquired activated protein C resistance; acquired deficiencies of protein C, protein S, and antithrombin III; and hyperhomocystinemia. Although patients with COVID-19 are hypercoagulable, there is no evidence at present to demonstrate an association between the SARS-CoV-2 virus and cerebral venous sinus thrombosis in children (01; 07).

Genetic causes of cerebral sinovenous thrombosis include novel mutation in Serpin C1 gene, which presents as unprovoked neonatal cerebral sinovenous thrombosis. This mutation causes a type 1 antithrombin (AT) deficiency and presents within the first week of life. Mutations in the A1 gene (Serpin C1) are associated with an 18-fold increase risk of cerebral sinovenous thrombosis (41).

JAK2 (Janus Kinase 2) V617F mutation causes cerebral sinovenous thrombosis without an underlying hematological abnormality diagnostic for myeloproliferative neoplasms (28).

El-Khoury and colleagues have reported that children undergoing therapy for acute lymphoblastic leukemia (ALL) had 10.5% incidence of cerebral sinovenous thrombosis if the following are present: intermediate/high risk disease, triglyceride levels greater than 615 mg/dl, mediastinal mass, and larger body surface (22).

Cerebral sinovenous thrombosis due to gain of function pathogenic variants in PIK3CA associated with megalencephaly-capillary malformation-polymicrogyria (MCAP) syndrome has been reported (29).

The brain’s venous drainage consists of a network of dural sinuses, cerebral veins, and cortical veins, which are divided into the superficial and deep systems. The superficial venous system consists of cortical veins and the superior sagittal sinus that drains into the torcular and then predominantly into right transverse (lateral) sinus, and right internal jugular vein. The deep system consists of inferior sagittal sinus, basal vein of Rosenthal, and paired internal cerebral veins that empty into the vein of Galen and then the straight sinus, which finally drains into the torcular. The deep system drains predominantly into the smaller-caliber left transverse (lateral) sinus and left internal jugular vein. Anteriorly, the paired cavernous sinuses are connected to the jugular system by the petrosal sinuses.

The cerebral venous system is a valveless system functioning at a low pressure and slow velocity. The venous sinuses encased in the rigid dura are non-collapsible. This results in a passive drainage of blood flow from the brain to the heart (12). The flow in the sinuses is gravity- and respiration-dependent and can be bi-directional depending on the venous pressure gradient. Reduction in systemic blood pressure can result in stasis or reversal of blood flow within dural sinuses. A relative reduction of thrombomodulin in the lining of cerebral sinuses further increases the propensity to thrombus formation (45). Dural sinuses play an important role in cerebrospinal fluid (CSF) dynamics due to presence of arachnoid granulations.

In cerebral sinovenous thrombosis, the mechanism for venous infarction is obstruction of venous drainage with increasing venous pressure in the region of brain drained by that vein or venous sinus, in the absence of venous collaterals. Venous congestion results in extravasation of fluid into the brain, producing focal or diffuse cerebral edema and hemorrhage due to diapedesis of red blood cells through capillaries. The edema may be transient if venous flow is re-established, or it may be associated with permanent tissue infarction if the increased venous blood pressure exceeds the arterial perfusion pressure. In the latter situation, there is inadequate delivery of arterial blood and regional ischemic “venous” infarction results (09; 47). Once the initial thrombus has formed, the ensuing obstruction and venous stasis can promote propagation of the initial thrombus. Relief of obstruction, even if delayed, can ease the venous congestion in cerebral sinovenous thrombosis completely. Occlusion of superior sagittal sinus or dominant transverse sinus impairs the function of arachnoid granulations, which interferes with CSF absorption and increases venous congestion and may result in communicating hydrocephalus (47). If the raised intracranial pressure is severe, pressure on the optic nerves causes papilledema, which if unrelieved over time can progress to optic atrophy and visual impairment.

Differential diagnosis

In neonates, cerebral sinovenous thrombosis may be overlooked as the cause of seizures or obtundation, particularly in the context of hypoxic-ischemic encephalopathy, metabolic acidosis, or sepsis. Poor feeding, irritability, and hyper- or hypotonia are also symptoms and signs to consider in neonatal presentation of cerebral sinovenous thrombosis (17; 71). Cerebral sinovenous thrombosis, like intracranial hemorrhage, should be considered as a cause of neurologic deterioration in sick patients. Cerebral sinovenous thrombosis should be distinguished from arterial ischemic stroke, post-asphyxial parasagittal injury, and contusion following trauma (40). In older children, early or mild cases of cerebral sinovenous thrombosis may be difficult to distinguish from idiopathic intracranial hypertension or other causes of raised intracranial pressure. Clinical diagnosis may be difficult in the context of infections that may themselves precipitate thrombosis. A high suspicion of cerebral sinovenous thrombosis should be maintained in a child or neonate with (1) unexplained seizures and/or encephalopathy and (2) new onset/worsening of preexisting seizures and/or encephalopathy in the presence of coexisting neurologic or systemic disorders. Furthermore, when assessing a suspected intravenous filling defect on neuroimaging, the clinician must consider a differential diagnosis in mind including: most commonly, (1) asymmetry of the transverse sinuses; (2) extraaxial fluid collections; and (3) arachnoid granulations (10; 38; 39). The appearance of the thrombus at various ages and on different MRI pulse sequences is helpful in differentiating a thrombus from these mimics and preventing unnecessary treatment.

Diagnostic workup

Investigations performed in cerebral sinovenous thrombosis should be aimed at (1) confirmation of the diagnosis and delineating the extent of brain injury, (2) screening for prothrombotic disorders, and (3) correctly identifying associated risk factors.

The diagnosis of cerebral sinovenous thrombosis is not possible only clinically. Neuroimaging with dedicated sequences of the intracranial venous system is mandatory. Knowledge of the normal variations in the venous anatomy as well as advantages and limitations of available imaging techniques is important (23; 67; 81). Computed tomography (CT) is frequently performed in most children due to ease of availability, short procedure time, and capacity to detect acute hemorrhage. Plain or unenhanced CT can miss cerebral sinovenous thrombosis; hence, contrast study is essential. CT can also yield false positive results in neonates. Signs indicative of cerebral sinovenous thrombosis on a non-contrast CT are the ‘‘filled triangle’’ or ‘‘dense triangle’’ sign or the ‘‘cord sign,’’ which describe the increased density of an intraluminal thrombus in sinovenous channels. On contrast-enhanced CT, ‘‘empty triangle’’ or ‘‘empty delta’’ sign refers to a non-contrast enhancing thrombus surrounded by the dural walls of the sinus, which enhance with contrast. CT venography using a multi-slice technique has been reported to be better than routine CT and a good substitute for MRI and MR venography in adults (57). However, the radiation risk needs to be duly considered in the pediatric age group. MRI is the preferred modality in most instances because of its ability to demonstrate flow, thrombus, edema, infarction, and concurrent abnormalities. On conventional MR images, acute thrombus (1-3 days) within a cerebral vein or dural sinus is isointense on T1-weighted images and hypointense on T2-weighted images. In the subacute stage (7-14 days), thrombus is hyperintense on T1-weighted images as well as T2-weighted images. In addition to conventional MRI, dedicated MR venography is essential to document flow disturbance in the affected sinovenous channel. Several techniques such as time-of-flight, phase contrast, and contrast-enhanced MR venography are helpful. Sensitivity and lack of radiation are major advantages of MRI over CT, but the need for sedation and the availability of urgent/emergent time are the main limitations. There is limited experience with diffusion-weighted imaging in neonates and children with cerebral sinovenous thrombosis as opposed to that with adults (19). Diffusion-weighted imaging, in addition to shedding light on mechanisms of brain injury in cerebral sinovenous thrombosis, has been reported to be useful in predicting recanalization in adults (24) and perhaps might be useful in children, although there are conflicting data for the pediatric population (50; 78). There is limited experience with imaging modalities other than CT and MRI. Cranial ultrasound is helpful for diagnosing centrally located venous infarcts or hemorrhages in infants with an open fontanelle. The technique, however, is highly operator-dependent; hence, diagnosis is tricky based on ultrasound alone. Its major advantage is the bedside availability and noninvasive nature. Doppler ultrasound can define absent/reduced flow in the sinovenous channels in cerebral sinovenous thrombosis, but mainly in the superior sagittal sinus (48; 61). Catheter cerebral angiography is rarely required nowadays for cerebral sinovenous thrombosis diagnosis due to the advent of CT and MRI. Although MR may be preferred for its lack of radiation, CT venogram is at least equivalent in sensitivity for cerebral venous sinus thrombosis diagnosis. There continues to be variability in employment of imaging modalities for pediatric cerebral venous sinus thrombosis. Importance of standardization of imaging pathways for pediatric cerebral venous sinus thrombosis have been reviewed (43). Adopting specific imaging protocols for cerebral venous sinus thrombosis aids in diagnostic precision and targeting management, which impacts outcome.

In both neonates and children, multiple sites are often involved in cerebral sinovenous thrombosis. The superficial system, including the superior sagittal and transverse sinuses, is involved in the majority. In severe cases, both superficial and deep systems may be thrombosed. Between 50% and 90% of neonates and children with cerebral sinovenous thrombosis have venous infarcts (55; 31; 52). In neonates, over three-quarters of infarcts are hemorrhagic (04), whereas in older infants and children a third are hemorrhagic (52). With thrombosis of the superficial system, infarcts are located in the cortex and white matter and may be bilateral (76). With thrombosis of the deep system, the infarcts are usually located in one or both thalami or the cerebellum (76; 04). In term newborns with intraventricular or thalamic hemorrhage, cerebral sinovenous thrombosis involving the deep system may be the underlying cause and should be sought (83). There probably are differences in the pattern of brain injury due to cerebral sinovenous thrombosis between term and preterm newborns (36). Isolated cortical venous thrombosis in absence of dural sinus involvement is also possible (63).

Testing for prothrombotic risk factors typically includes activated partial thromboplastin time, INR, antithrombin III, protein C and protein S levels, plasma fibrinogen, anticardiolipin antibodies, lupus anticoagulant, Factor V Leiden mutation, MTHFR mutation, prothrombin gene (G20210A) mutation, plasminogen, lipoprotein-a, Factor VIII, and plasma homocysteine. The results of these should be interpreted based on local laboratory standards, and age should be taken into consideration when interpreting values. The presence of prothrombotic abnormalities varies widely across studies (08; 82), and whether they are true causal associations with cerebral sinovenous thrombosis is not clear, as many seem to be transient and most are negative on repeat testing (52).

Lastly, a thorough screening for risk factors is helpful to determine the condition predisposing to cerebral sinovenous thrombosis, based on the individual case scenario. This may include but is not limited to investigations like blood counts, electrolytes, inflammatory work-up, iron studies, CSF, and microbial cultures, as per the clinical indication.

Management

The mainstays of management of childhood cerebral sinovenous thrombosis are (1) targeting the risk factor, (2) neuroprotection, and (3) judicious consideration for antithrombotic therapy.

Removal and/or avoidance and/or treatment of the associated risk factor are important, as alleviation of the underlying “hypercoagulable state” predisposing to thrombosis is critical. Prompt attention to perinatal risk factors, intracranial infections, and hematological/heart/liver/kidney disease is suggested. Dehydration and iron deficiency anemia are important targets. Neuroprotective measures are aimed at preventing and limiting the extent of venous infarction and brain injury. Maintenance of temperature, blood pressure, glucose, blood volume, and treatment of seizures and raised intracranial pressure are essential. The role of prophylactic anticonvulsants is controversial, but a low threshold for EEG is helpful. Seizures can increase infarct volume and resultant brain injury. The role of anti-edema measures is relatively better defined in adults than in children. Mannitol and acetazolamide can be considered on an individual case basis, although it is important to remember that both induce diuresis, which can cause volume depletion that in turn could theoretically worsen thrombosis. Positive pressure ventilation and decompressive craniectomy are other therapies for life-threatening raised intracranial pressure, although these should be considered on the merit of individual situations.

Specific antithrombotic therapy includes anticoagulant therapy, antiplatelet therapy, and thrombolytic therapy. In childhood cerebral sinovenous thrombosis, unfractionated heparin, low-molecular-weight heparin, and vitamin K antagonists (warfarin) are the main anticoagulants. The rationale of anticoagulant therapy is to prevent propagation and thereby enable the unopposed dissolution (recanalization) of the existing thrombus, by the fibrinolytic system. Safety of anticoagulant therapy has been established in adults even in presence of intracranial hemorrhage and is the standard practice (20; 15; 21; 65). Older children are increasingly treated based on adult data, but many neonates are still not treated (34; 33). Data have confirmed the safety of anticoagulant therapy with low hemorrhagic complication (non-fatal) rate (5%) in cerebral sinovenous thrombosis (04; 52) in both neonates and older children. It has also been shown that in the absence of anticoagulant therapy, worsening/propagation of thrombosis occur in over one third of neonates and children (52; 51; 59). Propagation can be accompanied by new venous infarction in 10% to 40% of cases (52; 51). Thus, there could be some risk in not giving anticoagulant therapy to neonates and children with cerebral sinovenous thrombosis. However, the effect of anticoagulant therapy on the long-term clinical outcome, particularly neonates, who generally tend to have worse outcomes, is not yet known.

Two consensus-based guidelines [American College of Chest Physicians (ACCP) and American Heart Association (AHA)] have reviewed anticoagulant therapy in childhood cerebral sinovenous thrombosis (53; 26). Anticoagulant therapy is suggested in older children in the absence of significant intracranial hemorrhage (AHA class IIa, level of evidence C; ACCP level of evidence grade 1B). In the presence of a significant hemorrhage, anticoagulation could be initiated or radiographic monitoring could be performed at 5 to 7 days on a case-by-case base. If there is evidence of thrombosis propagation on serial imaging, anticoagulation should be initiated (ACCP level of evidence grade 2C). Both guidelines offer similar recommendations regarding the treatment of cerebral sinovenous thrombosis in neonates. The ACCP guidelines suggest anticoagulation in the absence of significant intracranial hemorrhage (level of evidence grade 2C). In the presence of a significant hemorrhage, they recommend either anticoagulation or supportive care with serial imaging of the thrombosis at 5 to 7 days and anticoagulation if thrombus extension occurs (level of evidence grade 2C). The most recent AHA guidelines also state that anticoagulation with low molecular weight heparin or standard heparin may be considered in neonates with cerebral sinovenous thrombosis, especially if there is evidence of clinical deterioration or thrombus extension on serial imaging. They also recommend performing serial imaging 5 to 7 days after diagnosis to exclude propagation if the decision is made not to anticoagulated.

Direct antithrombin inhibitors such as bivalirudin have been anecdotally used in specific cases of apparent heparin resistance but no large cohort study has been performed to assess efficacy and safety (06). Data on direct oral anticoagulants are emerging in pediatric venous thromboembolism with a potential for future clinical trials in pediatric cerebral sinovenous thrombosis (11; 46).

Other therapies such as antiplatelet agents like aspirin do not seem to have a role in cerebral sinovenous thrombosis, as the coagulation system rather than platelets is the chief player in the thrombotic process, although aspirin has on rare occasions been administered in some patients when anticoagulant therapy has failed to halt the propagation of cerebral sinovenous thrombosis (authors’ personal communication). There are no clinical trials to inform the role of thrombocytic agents such as tissue plasminogen activator, urokinase, streptokinase, or mechanical thrombectomy, other than small case series (79; 56). In general, these should be perhaps reserved only for very aggressive cerebral sinovenous thrombosis that worsens despite adequate anticoagulant therapy. The safety in children is not clear; therefore, outside of clinical trials, use of these agents is not recommended. The ACCP recommends that thrombolysis, thrombectomy, or surgical decompression be performed only in children with severe cerebral sinovenous thrombosis in whom there is no improvement with initial unfractionated heparin therapy (grade 2C).

Endovascular techniques such as venous mechanical thrombectomy for treating refractory cerebral sinovenous thrombosis may be considered in carefully selected cases. Centers with experienced neurointerventionalists with neurovascular multidisciplinary team set up is key to implementing this practice. Evidence of clinical or radiographic progression despite anticoagulation may be candidates for venous thrombectomy. Mortimer and colleagues present a series of nine children in poor clinical condition who underwent endovascular therapies (54). Several methods were used including local tPA, microguidewire and catheter disruption, balloon angioplasty, and thromboaspiration using the Penumbra device. Eight children had good functional outcomes. A small case series of seven children described using mechanical thrombectomy for children in whom neurologic deterioration occurred despite optimal anticoagulation therapy—six out of seven had venous infarct preoperatively. In three out of seven children, intrasinus thrombolytic therapy (tPA) was used (30). Six out of seven children had favorable outcome with mRS 0 or one 90 days post procedure. Catheter directed thrombolytic (CDT) therapy has also been used as adjunctive therapy to venous thrombectomy. Torres and colleagues described a case series of five children where CDT therapy was used for 17 to 48 hours at a dose of 1 to 2 mg/hr. Unfractionated heparin was continued during this time (77). All children had partial resolution of clot burden, and one child had rapid reocclusion. Important complications of CDT that may occur and important during decision making include: post-procedure bleeding, parenchymal/intraventricular hemorrhage, and petechial brain hemorrhage.

The role of decompressive craniectomy for cerebral sinovenous thrombosis in children is lacking in the literature, although adult data are available. It is performed when clinical deterioration includes hemorrhagic venous infarct, raised intracranial pressure, and risk of imminent cerebral herniation as a life-saving procedure. Theoretically, decompression alleviates pressure on the sinuses due to edema from the brain and may help in restoring venous flow. This, however, requires pausing unfractionated heparin; consensus opinion on timing of recommencement of unfractionated heparin is not available, and variability in practice continues. Therapy with unfractionated heparin remains vital for ongoing management postoperatively. Published guidelines and recommendations for surgical and interventional management are lacking at present; future studies are required.

Outcomes

Neurologic deficits are often present at the time of discharge. Motor and cognitive sequelae may require long-term rehabilitation regimens (18). Some of the neurologic symptoms that children may suffer after cerebral venous sinus thrombosis include (but not restricted to) headache, visual impairment, and cranial nerve VI palsy secondary to intracranial pressure. Deficits that may be present due to venous infarction range from developmental delay, learning disabilities, hemiparesis, and hemisensory loss. Children who have been anticoagulated are more likely to have good cognitive outcome (66). Statistically significant association with death in those with a Glasgow coma score of less than 12. The neurologic sequelae is dependent on whether the cerebral venous sinus thrombosis results in parenchymal injury that either leads to venous infarct (cortical or subcortical), deep nuclei (basal ganglia and thalamus), or primary hemorrhage, resulting in intra or extra parenchymal injury with intraventricular hemorrhage, subdural, or subarachnoid hemorrhage.

Slim and colleagues studied the neurocognitive outcome following cerebral venous sinus thrombosis with a prospective observational study (68). Most children with cerebral venous sinus thrombosis exhibited emerging cognitive deficits. The domains tested included intellectual disability, executive function, attention, language, or behavior. Slim and colleagues looked at 50 children with a median age of 2 years 10 months, with a median follow-up time of 4 years (68). When compared with normative children, those who had suffered cerebral venous sinus thrombosis had a lower mean full scale IQ, with lower working memory and processing speed scores. Executive function, attention, and language domains were also affected with lower scores. Interestingly, the verbal comprehension index did not differ. Spearing of verbal ability after cortical lesions was a consistent finding across multiple studies irrespective of type of lesion, laterality, and age (80; 68). Children with cerebral venous sinus thrombosis demonstrated difficulty with verbal learning and memory. Children with behavioral problems were also those who had refractory seizures at presentation. Females are less likely than males to experience difficulties with processing speed.

It is important to note that this study showed that no differences in cognitive outcomes were associated with age at cerebral venous sinus thrombosis presentation (neonate vs. non-neonate), neurologic comorbidity, presence of seizure disorder, number of dural vessels involved (except for adaptive skills), and presence of parenchymal injury (infarct or hemorrhage).

The use of anticoagulation and association with neurologic outcomes has been reported (25). Treatment and outcomes in 410 children from the International Pediatric Stroke Study (IPSS) were studied using the Pediatric Stroke Outcome Measure (PSOM). Eighty two percent of children received anticoagulation; a multivariate analysis showed that anticoagulation was significantly associated with favorable outcomes and had a lower odds of severe neurologic impairment or death at hospital discharge. Further randomized control trials are, however, required to fully validate this.

References

01: Al-Mufti F, Amuluru K, Sahni R, et al. Cerebral venous thrombosis in COVID-19: A Yew York Metropolitan cohort study. AJNR Am J Neuroradiol 2021;42(7):1196-200. PMID 33888450
02: Andrew M, Paes B, Johnston M. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 1990;12(1):95-104. PMID 2178462
03: Ballem P. Acquired thrombophilia in pregnancy. Semin Thromb Hemost 1998;24 Suppl 1:41-7. PMID 9840691
04: Berfelo FJ, Kersbergen KJ, van Ommen CH, et al. Neonatal cerebral sinovenous thrombosis from symptom to outcome. Stroke 2010;41(7):1382-8. PMID 20522810
05: Baumgartner RW, Studer A, Arnold M, Georgiadis D. Recanalisation of cerebral venous thrombosis. J Neurol Neurosurg Psychiatry 2003;74(4):459-61. PMID 12640063
06: Bertamino M, Severino M, Parodi A, et al. Bivalirudin anticoagulation to overcome heparin resistance in a neonate with cerebral sinovenus thrombosis. Blood Coagul Fibrinolysis 2020;31(1):97-100. PMID 31833869
07: Beslow LA, Linds AB, Fox CK, et al. Pediatric ischemic stroke: an infrequent complication of SARS-CoV-2. Ann Neurol 2021;89(4):657-65. PMID 33332607
08: Bonduel M, Sciuccati G, Hepner M, Torres AF, Pieroni G, Frontroth JP. Prethrombotic disorders in children with arterial ischemic stroke and sinovenous thrombosis. Arch Neurol 1999;56(8):967-71. PMID 10448802
09: Bousser MG. Cerebral venous thrombosis: diagnosis and treatment. J Neurol 2000;247:252-8. PMID 10836615
10: Bracken J, Barnacle A, Ditchfield M. Potential pitfalls in imaging of paediatric cerebral sinovenous thrombosis. Pediatr Radiol 2013;43(2):219-31. PMID 22948810
11: Brandao LR, Albisetti M, Halton J, et al. Safety of dabigatran etexilate for the secondary prevention of venous thromboembolism in children. Blood 2020;135(7):491-504. PMID 31805182
12: Capra N, Anderson K. Anatomy of the cerebral venous system. In: Knapp JP, Schmidek HH, editors. The cerebral venous system and its disorders. Orlando, FL: Grune and Stratton, 1984:1-36.
13: Claessens NHP, Algra SO, Jansen NJG, et al. Clinical and neuroimaging characteristics of cerebral sinovenous thrombosis in neonates undergoing cardiac surgery. J Thorac Cardiovasc Surg 2018;155(3):1150-8. PMID 29221746
14: Cowan F, Thoresen M. Changes in superior sagittal sinus blood velocities due to postural alterations and pressure on the head of the newborn infant. Pediatrics 1985;75(6):1038-47. PMID 3889817
15: de Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke 1999;30(3):484-8. PMID 10066840
16: deVeber G, Monagle P, Chan A, et al. Prothrombotic disorders in infants and children with cerebral thromboembolism. Arch Neurol 1998;55(12):1539-43. PMID 9865798
17: deVeber G, Andrew M, Adams C; Canadian Pediatric Ischemic Stroke Study Group. Cerebral sinovenous thrombosis in children. N Engl J Med 2001;345(6):417-23. PMID 11496852
18: Dlamini N, Billinghurst L, Kirkham FJ. Cerebral venous sinus (sinovenous) thrombosis in children. Neurosurg Clin N Am 2010;21(3):511-27. PMID 20561500
19: Dormont D, Anxionnat R, Evrard S, Louaille C, Chiras J, Marsault C. MRI in cerebral venous thrombosis. J Neuroradiol 1994;21(2):81-99. PMID 8014661
20: Einhaupl KM, Villringer A, Meister W, et al. Heparin treatment in sinus venous thrombosis. Lancet 1991;338(8767):597-600. PMID 1679154
21: Einhaupl K, Bousser MG, de Bruijn SF, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol 2006;13(6):553-9. PMID 16796579
22: El-Khoury H, Saifi O, Haddad S, et al. Treatment-induced cerebral sinus venous thrombosis in childhood acute lymphoblastic malignancies: New risk factors to consider. Pediatr Blood Cancer 2021;68(11):e29210. PMID 34327817
23: Farb RI, Scott JN, Willinsky RA, Montanera WJ, Wright GA, terBrugge KG. Intracranial venous system: gadolinium-enhanced three-dimensional MR venography with auto-triggered elliptic centric-ordered sequence--initial experience. Radiology 2003;226(1):203-9. PMID 12511691
24: Favrole P, Guichard JP, Crassard I, Bousser MG, Chabriat H. Diffusion-weighted imaging of intravascular clots in cerebral venous thrombosis. Stroke 2004;35(1):99-103. PMID 14699171
25: Felling RJ, Hassanein SMA, Armstrong J, et al. Treatment and outcome of childhood cerebral sinovenous thrombosis. Neurol Clin Pract 2020;10(3):232-44. PMID 32642325
26: Ferriero DM, Fullerton HJ, Bernard TJ, et al. Management of stroke in neonates and children: a scientific statement from the American Heart Association/American Stroke Association. Stroke 2019;50(3):e51-e96. PMID 30686119
27: Fitzgerald KC, Williams LS, Garg BP, Carvalho KS, Golomb MR. Cerebral sinovenous thrombosis in the neonate. Arch Neurol 2006;63(3):405-9. PMID 16533968
28: Forest C, Gallo P, Fumarola A, Burnelli R, Suppiej A. Jak2 mutation expands the thrombophilic panel in children. J Thromb Haemost 2020;18(10):2636-9. PMID 32654426
29: Fortin O, Ashour M, Lacroix C, Sabapathy CA, Myers KA. Megalencephaly–capillary malformation–polymicrogyria with cerebral venous thrombosis. Can J Neurol Sci 2020;47(6):828-9. PMID 32631464
30: Gadgil N, Aldave G, Whitehead WE, et al. Endovascular intervention for refractory pediatric cerebral venous sinus thrombosis. Pediatr Neurol 2021;121:45-50. PMID 34147818
31: Grunt S, Wingeier K, Wehrli E, et al; Swiss Neuropaediatric Stroke Registry. Cerebral sinus venous thrombosis in Swiss children. Dev Med Child Neurol 2010;52(12):1145-50. PMID 20573178
32: Heller C, Heinecke A, Junker R, et al. Cerebral venous thrombosis in children: a multifactorial origin. Circulation 2003;108(11):1362-7. PMID 12939214
33: Ichord RN, Benedict SL, Chan AK, Kirkham FJ Nowak-Gottl U; International Paediatric Stroke Study Group. Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study. Arch Dis Child 2015;100(2):174-9. PMID 25288688
34: Jordan LC, Rafay MF, Smith SE, et al; International Pediatric Stroke Study Group. Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study. J Pediatr 2010;156(5):704-10, 710.e1-e2. PMID 20149389
35: Kenet G, Kirkham F, Niederstadt T, et al; European Thromboses Study Group. Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort study. Lancet Neurol 2007;6(7):595-603. PMID 17560171
36: Kersbergen K, Groenendaal F, Benders M, et al. The spectrum of associated brain lesions in cerebral sinovenous thrombosis: relation to gestational age and outcome. Arch Dis Child Fetal Neonatal Ed 2011a;96:F404-9. PMID 21317440
37: Kersbergen K, Groenendaal F, Benders M, de Vries L. Neonatal cerebral sinovenous thrombosis: neuroimaging and long-term follow-up. J Child Neurol 2011b;26:1111-20. PMID 21693652
38: Kouzmitcheva E, Andrade A, Muthusami P, et al. Anatomical venous variants in children with cerebral sinovenous thrombosis. Stroke 2018a. [Epub ahead of print] PMID 30580715
39: Kouzmitcheva E, Krishnan P, Dlamini N, deVeber G, MacGregor DL, Moharir M. Child neurology: mimics of cerebral sinovenous thrombosis: a pediatric case series. Neurology 2018b;91(16):e1545-8. PMID 30323079
40: Krasnokutsky MV. Cerebral venous thrombosis: a potential mimic of primary traumatic brain injury in infants. AJR Am J Roentegenol 2011;197(3):W503-7. PMID 21862779
41: Kumar R, Moharir M, Yau I, Williams S. A novel mutation in the SerpinC1 gene presenting as unprovoked neonatal cerebral sinus venous thrombosis in a kindred. Pediatr Blood Cancer 2013;60(1):133-6. PMID 22997155
42: Laurichesse Delmas H, Winer N, Gallot D, et al. Prenatal diagnosis of thrombosis of the dural sinuses: report of six cases, review of the literature and suggested management. Ultrasound Obstet Gynecol 2008;32:188-98. PMID 18512853
43: Lee S, Mirsky DM, Beslow LA, et al. Pathways for neuroimaging of neonatal stroke. Pediatr Neurol 2017;69:37-43. PMID 28262550
44: Legendre D, Picone O, Levaillant JM, et al. Prenatal diagnosis of spontaneous dural sinus thrombosis. Prenat Diagn 2009;29:808-13. PMID 19415784
45: Lin JH, McLean K, Morser J, et al. Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin. J Biol Chem 1994;269(40):25021-30. PMID 7929188
46: Male C, Lensing AWA, Palumbo JS, et al. Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial. Lancet Haematol 2020;7(1):e18-27. PMID 31699660
47: Masuhr F, Mehraein S, Einhaupl K. Cerebral venous and sinus thrombosis. J Neurol 2004;251(1):11-23. PMID 14999484
48: Miller E, Daneman A, Doria AS, et al. Color Doppler US of normal cerebral venous sinuses in neonates: a comparison with MR venography. Pediatr Radiol 2012;42(9):1070-9. PMID 22532234
49: Mineyko A, Kirton A, Billinghurst L, et al. Seizures and outcome one year after neonatal and childhood cerebral sinovenous thrombosis. Pediatr Neurol 2020;105:21-6. PMID 31882182
50: Moharir M, deVeber G, Shroff M. Diffusion Weighted MR imaging of venous clots in cerebral sinovenous thrombosis in children: an aid to diagnosis and a potential predictor for recanalization. Ann Neurol 2006;60 Suppl 3:S157.
51: Moharir M, Shroff M, Pontigon A, et al. A prospective outcome study of neonatal cerebral sinovenous thrombosis. J Child Neurol 2011;26:1137-44. PMID 21628696
52: Moharir MD, Shroff M, Stephens D, et al. Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study. Ann Neurol 2010;67(5):590-9. PMID 20437556
53: Monagle P, Chan AK, Goldenberg NA, et al; American College of Chest Physicians. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141(2 Suppl):e737S-801S. PMID 22315277
54: Mortimer A, Bradley MD, O'Leary S, Renowden SA. Endovascular treatment of children with cerebral venous sinus thrombosis: a case series. Pediatric neurology 2013;49(5):305-12. PMID 24139531
55: Nwosu ME, Williams LS, Edwards-Brown M, Eckert GJ, Golomb MR. Neonatal sinovenous thrombosis: presentation and association with imaging. Pediatr Neurol 2008;39(3):155-61. PMID 18725059
56: Omoto K, Nakagawa I, Park HS, et al. Successful emergent endovascular mechanical thrombectomy for pediatric and young adult cerebral venous sinus thrombosis in coma. World Neurosurg 2019;122:203-08. PMID 30404063
57: Ozsvath RR, Casey SO, Lustrin ES, Alberico RA, Hassankhani A, Patel M. Cerebral venography: comparison of CT and MR projection venography. AJR Am J Roentgenol 1997;169(6):1699-707. PMID 9393193
58: Pandey V, Dummula K, Parimi P. Antenatal thrombosis of torcular herophili presenting with anemia, consumption coagulopathy and high-output cardiac failure in a preterm infant. J Perinatol 2012;32(9):728-30. PMID 22931961
59: Pergami P, Abraham L. Impact of anticoagulation on the short-term outcome in a population of neonates with cerebral sinovenous thrombosis: a retrospective study. J Child Neurol 2011;26:844-50. PMID 21551369
60: Radicioni M, Bini V, Chiarini P, et al. Cerebral sinovenous thrombosis in the asphyxiated cooled infants: a prospective observational study. Pediatr Neurol 2017;66:63-8. PMID 27823842
61: Raets MM, Sol JJ, Govaert P, et al. Serial cranial US for detection of cerebral sinovenous thrombosis in preterm infants. Radiology 2013;269(3):879-86. PMID 23985276
62: Ranta S, Tuckuviene R, Mäkipernaa A, et al. Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology. Br J Haematol 2015;168(4):547-52. PMID 25288392
63: Ritchey Z, Hollatz AL, Weitzenkamp D, et al. Pediatric cortical vein thrombosis: frequency and association with venous infarction. Stroke 2016;47(3):866-8. PMID 26888536
64: Rivkin MJ, Saraiya PV, Woodrow SI. Sinovenous thrombosis associated with skull fracture in the setting of blunt head trauma. Acta Neurochir (Wien) 2014;156(5):999-1007. PMID 24573982
65: Sacco RL, Adams R, Albers G, et al; American Heart Association; American Stroke Association Council on Stroke; Council on Cardiovascular Radiology and Intervention; American Academy of Neurology. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke 2006;37(2):577-617. PMID 16432246
66: Sebire G, Tabarki B, Saunders DE, et al. Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome. Brain 2005;128(Pt 3):477-89. PMID 15699061
67: Shroff M, deVeber G. Sinovenous thrombosis in children. Neuroimaging Clin N Am 2003;13(1):115-38. PMID 12802944
68: Slim M, Aziz AS, Westmacott R, et al. Long-term cognitive outcomes after cerebral sinovenous thrombosis in childhood. Dev Med Child Neurol 2020;62(12):1437-43. PMID 32909303
69: Soman TB, Moharir M, DeVeber G, Weiss S. Infantile spasms as an adverse outcome of neonatal cortical sinovenous thrombosis. J Child Neurol 2006;21(2):126-31. PMID 16566876
70: Sorg AL, Klemme M, von Kries R, et al. Clinical diversity of cerebral sinovenous thrombosis and arterial ischaemic stroke in the neonate: a surveillance study. Neonatology 2021;118(5):530-6. PMID 33784682
71: Steggerda SJ, de Vries LS. Neonatal stroke in premature neonates. Seminars in Perinatology 2021;45(7):151471. PMID 34465449
72: Stolz E, Trittmacher S, Rahimi A, et al. Influence of recanalization on outcome in dural sinus thrombosis: a prospective study. Stroke 2004;35(2):544-7. PMID 14715977
73: Strupp M, Covi M, Seelos K, Dichgans M, Brandt T. Cerebral venous thrombosis: correlation between recanalization and clinical outcome--a long-term follow-up of 40 patients. J Neurol 2002;249(8):1123-4. PMID 12420718
74: Symonds CP. Otitic hydrocephalus. Brain 1931;54:55-71.
75: Tan M, deVeber G, Shroff M, et al. Sagittal sinus compression is associated with neonatal cerebral sinovenous thrombosis. Pediatrics 2011;128:e429-35. PMID 21746724
76: Teksam M, Moharir M, Deveber G, Shroff M. Frequency and topographic distribution of brain lesions in pediatric cerebral venous thrombosis. AJNR Am J Neuroradiol 2008;29(10):1961-5. PMID 18687742
77: Torres M, Hamby T, Philip S, Tilley JA. Catheter directed thrombolytic therapy for pediatric cerebral sinus vein thrombosis. Blood 2019;134(Suppl 1):3666.
78: Wagner MW, Bosemani T, Oshmyansky A, Poretti A, Huisman TA. Neuroimaging findings in pediatric cerebral sinovenous thrombosis. Childs Nerv Syst 2015;31(5):705-12. PMID 25715842
79: Wasay M, Bakshi R, Kojan S, Bobustuc G, Dubey N, Unwin DH. Nonrandomized comparison of local urokinase thrombolysis versus systemic heparin anticoagulation for superior sagittal sinus thrombosis. Stroke 2001;32(10):2310-7. PMID 11588319
80: Westmacott R, MacGregor D, Askalan R, deVeber G. Late emergence of cognitive deficits after unilateral neonatal stroke. Stroke 2009;40(6):2012-9. PMID 19423855
81: Widjaja E, Shroff M, Blaser S, Laughlin S, Raybaud C. 2D time-of-flight MR venography in neonates: anatomy and pitfalls. AJNR Am J Neuroradiol 2006;27(9):1913-8. PMID 17032865
82: Wu YW, Miller SP, Chin K, et al. Multiple risk factors in neonatal sinovenous thrombosis. Neurology 2002;59(3):438-40. PMID 12177381
83: Wu YW, Hamrick SE, Miller SP, et al. Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis. Ann Neurol 2003;54(1):123-6. PMID 12838529
84: Xavier F, Komvilaisak P, Williams S, Kulkarni AV, deVeber G, Moharir MD. Anticoagulant therapy in head injury-associated cerebral sinovenous thrombosis in children. Pediatr Blood Cancer 2014;61(11):2037-42. PMID 25111001

Contributors

All contributors' financial relationships have been reviewed and mitigated to ensure that this and every other article is free from commercial bias.

Authors

Mahendranath D Moharir MD MSc

Dr. Moharir of the University of Toronto has no relevant financial relationships to disclose.
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Samyami Chowdhury BSc(hons) MBChB MRCPCH

Dr. Chowdhury of the Hospital for Sick Children has no relevant financial relationships to disclose.
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Editor

Bernard L Maria MD

Dr. Maria of Thomas Jefferson University has no relevant financial relationships to disclose.
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Former Authors

David A Griesemer MD
Gabriel M Pitman MD
Gabrielle deVeber MD MHSc
Bernard L Maria MD
Matsanga Leyila Kaseka MD FRCPC
A Keith W Brownell MD

Patient Profile

Age range of presentation: 0 month to 18 years
Sex preponderance: male=female
Heredity: none
Population groups selectively affected: none selectively affected
Occupation groups selectively affected: none selectively affected

ICD & OMIM codes

ICD-9: Phlebitis and thrombophlebitis of intracranial venous sinuses: 325
ICD-10: Intracranial and intraspinal phlebitis and thrombophlebitis: G08

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Cerebral venous thrombosis in infants and children

Associated Disorders

Asphyxia
Coagulation disorders
Dehydration
Hypercoagulability
Meningitis

Differential Diagnosis

arterial ischemic stroke
post-asphyxial parasagittal injury
contusion following trauma
idiopathic intracranial hypertension or other causes of raised intracranial pressure
infections that may themselves precipitate thrombosis
- asymmetry of the transverse sinuses
- extraaxial fluid collections
- arachnoid granulations

Also Relevant

Cerebral venous thrombosis
Hypercoagulable states and cerebrovascular disease
Intracerebral hemorrhage due to thrombolytic therapy
Pregnancy: CNS complications
Stroke in young adults
- Vein of Galen malformations

Cerebral venous thrombosis in infants and children …

Cerebral venous thrombosis in infants and children

Introduction

Overview

Key points

Historical note and terminology

Clinical manifestations

Presentation and course

Prognosis and complications

Clinical vignette

Biological basis

Etiology and pathogenesis

Epidemiology

Differential diagnosis

Diagnostic workup

Management

Outcomes

References

Contributors

Authors

Editor

Former Authors

Patient Profile

ICD & OMIM codes

This is an article preview.
Start a Free Account
to access the full version.

Questions or Comment?

Also in This Category

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Cerebral venous thrombosis in infants and children

Introduction

Overview

Key points

Historical note and terminology

Clinical manifestations

Presentation and course

Prognosis and complications

Clinical vignette

Biological basis

Etiology and pathogenesis

Epidemiology

Differential diagnosis

Diagnostic workup

Management

Outcomes

References

Contributors

Authors

Editor

Former Authors

Patient Profile

ICD & OMIM codes

This is an article preview. Start a Free Account to access the full version.

Questions or Comment?

Also in This Category

Zika virus: neurologic complications

CNS germinoma

Vein of Galen malformations

Hemorrhagic transformation of ischemic stroke

Thalamic hemorrhage

Infective endocarditis

Cerebellar astrocytoma

Rare brain embryonal tumors in infancy and early childhood

This is an article preview.
Start a Free Account
to access the full version.