CNS infection with rickettsia species and related organisms …

Christina M Marra MD

Infectious Disorders

Updated 07.03.2024
Released 03.05.2023
Expires For CME 07.03.2027

Central nervous system infection with Rickettsia species and related organisms

Author: Christina M Marra MD

See Contributor Disclosures

Editor: John E Greenlee MD

Central nervous system infection with Rickettsia species and related organisms

In This Article

Quick Link

Introduction

Overview

Rickettsia species and related organisms that cause CNS infection in the United States include Rocky Mountain spotted fever, caused by Rickettsia rickettsii; other spotted fever rickettsioses; ehrlichiosis, most commonly caused by Ehrlichia chaffeensis; and anaplasmosis, caused by Anaplasma phagocytophilum. African tick bite fever, which is also included in the spotted fever group, is caused by Rickettsia africae. In the United States, infection with R africae is commonly seen in travelers returning from sub-Saharan Africa. Rickettsia typhi and Rickettsia prowazekii are members of the typhus group of Rickettsia species. R typhi is the cause of murine typhus. R prowazekii, the cause of epidemic typhus, is of historical interest because of major outbreaks during World War I. Epidemics continue to occur in the setting of war, famine, displacement, and crowding. Orientia tsutsugamushi is the most common cause of scrub typhus. Scrub typhus was the most significant rickettsiosis affecting United States troops during World War II. Scrub typhus continues to be a major health problem in the Asia-Pacific region, and it is seen in the United States in returning travelers.

This article discusses Rocky Mountain spotted fever, anaplasmosis, ehrlichiosis caused by Ehrlichia chaffeensis (hereafter ehrlichiosis), African tick bite fever, murine or endemic typhus, epidemic typhus, and scrub typhus. The general clinical presentations of all these illnesses are similar, with headache, fever, and rash, but there may be geographical and clinical clues to individual etiologies. Unlike Rocky Mountain spotted fever, anaplasmosis and ehrlichiosis are less likely to present with rash, and both have a unique histopathology or morulae, which are intracytoplasmic inclusions in peripheral white blood cells. African tick bite fever characteristically presents with one or more cutaneous eschars at the site of inoculation, as does scrub typhus. Murine and epidemic typhus are indistinguishable clinically and pathologically, except that epidemic typhus is a more severe disease. The treatment of choice for all these infections is doxycycline, and it should be started when they are suspected without waiting for diagnostic test results.

Key points

	• Rocky Mountain spotted fever, ehrlichiosis, anaplasmosis, and African tick bite fever are transmitted by ticks.
	• Murine typhus is transmitted by flea feces, epidemic typhus by body lice feces, and scrub typhus by chigger bites.
	• Human-to-human transmission does not occur for these illnesses, except for infection with R prowazekii, which can recur as Brill-Zinsser disease years after initial infection. Patients with recurrent disease can serve as reservoirs in settings where human body lice are prevalent.
	• Rocky Mountain spotted fever is the most common rickettsial illness in the United States.
	• Early symptoms of Rocky Mountain spotted fever are nonspecific and include high fever, headache, and a macular rash. However, the lack of any of these features does not exclude the diagnosis.
	• Anaplasmosis and ehrlichiosis have symptoms that are similar to Rocky Mountain spotted fever, but they less commonly include rash.
	• Anaplasmosis is characterized by morulae in granulocytes.
	• Ehrlichiosis is characterized by morulae in monocytes.
	• The illness of African tick bite fever is similar to that of Rocky Mountain spotted fever, but patients have one or more distinctive cutaneous eschars.
	• Murine typhus is generally a mild disease, but it can present with meningoencephalitis alone.
	• Louse-borne epidemic typhus causes frequent neurologic disease.
	• In the United States, cases of epidemic typhus are associated with exposure to flying squirrels and their nests. Disease in this setting is milder than louse-borne epidemic typhus.
	• Scrub typhus is a common cause of meningoencephalitis in endemic areas.
	• Doxycycline at 2.2 mg/kg orally or intravenously BID (maximum 100 mg BID) is the first-line treatment for adults and children of all ages with rickettsial and related infections, including pregnant women, and should be started while awaiting laboratory confirmation.

Historical note and terminology

Rocky Mountain spotted fever. Rocky Mountain spotted fever was originally described in Montana and Idaho in the 1870s. The extensive investigative work of Dr. Howard Taylor Ricketts between 1906 and 1909 led to the identification of the etiologic agent, Rickettsia rickettsii, and confirmed the tick as the vector (56). Wolbach confirmed that the bacterium responsible for Rocky Mountain spotted fever was carried by wood ticks and that it was an obligate intracellular pathogen (69). Rocky Mountain spotted fever has been reportable in the United States since the 1920s.

Anaplasmosis. A phagocytophilum was first identified in humans in 1994. It was originally thought to be a new species of Ehrlichia, and it was named Ehrlichia phagocytophilum; the disease it caused was called human granulocytic ehrlichiosis. In 2001, E phagocytophilum was renamed A phagocytophilum, and the disease was renamed human granulocytic anaplasmosis, or more commonly, anaplasmosis (45). Anaplasmosis has been reportable in the United States since 1999.

Ehrlichiosis. The first instance of human infection with E chaffeensis was documented in 1986 in a man bitten by ticks in the state of Arkansas in the United States. He presented with fever and confusion and then developed anemia and thrombocytopenia. Morulae within monocytes were identified, and treatment with doxycycline was curative (65). Ehrlichiosis became a reportable disease in the United States in 1994.

African tick bite fever. Despite its first description in 1911, African tick bite fever was erroneously attributed to Mediterranean spotted fever until 1992, when the disease and the causative agent, R africae, were described; they became official in 1996 (37). African tick bite fever is endemic in rural sub-Saharan Africa, the Caribbean, and Oceana (58). It is responsible for about half of published travel-related rickettsial infections (58; 20).

Murine typhus. Murine typhus, also called “urban” or “shop” typhus, is caused by R typhi (previously R mooseri). It was distinguished from epidemic typhus in the mid-1920s. It is generally acquired in urban environments (38). Murine typhus was nationally reportable in the United States from 1930 to 1987; it remains reportable in some states.

Epidemic typhus. Epidemic typhus, also called “louse-borne typhus,” “ship fever,” “war fever,” “jail fever,” and “camp fever,” is caused by R prowazekii. Transmission by the human body louse was identified in 1909, and the causative agent was identified in 1916 (38). Epidemic typhus typically occurs in settings of war, famine, crowding, and homelessness where hygiene is poor and lice infestation occurs. Because lice live in clothing, it is also more common in colder climates. Recurrence of R prowazekii infection years after initial infection, or Brill-Zinsser disease, was discovered in the late 1890s (38). Patients with recurrent disease can serve as reservoirs in settings where human body lice are prevalent. R prowazekii infection associated with exposure to flying squirrels in the United States was first noted in the late 1970s (48).

Scrub typhus. Scrub typhus, also called “chiggerborne rickettsiosis,” “tsutsugamushi disease,” “tropical typhus,” or “rural typhus,” is primarily caused by Orientia tsutsugamushi. It is transmitted to humans by the bite of the parasitic larval chigger stage of Leptotrombidium mites. It was first described in the medical literature in Japan in 1810, and the cause was identified in Japan in the late 1920s (38). Scrub typhus was the most significant rickettsiosis affecting United States troops during World War II (38).

Clinical manifestations

Presentation and course

	• Early symptoms of Rocky Mountain spotted fever are nonspecific and include high fever, headache, myalgias, and gastrointestinal symptoms. The characteristic rash begins 2 to 4 days after the onset of fever.
	• The classic Rocky Mountain spotted fever triad of tick bite, rash, and fever is uncommon at first presentation.
	• The main neurologic complications of Rocky Mountain spotted fever are meningoencephalitis and cerebral edema.
	• Anaplasmosis presents similarly to Rocky Mountain spotted fever, with nonspecific symptoms; however, rash is uncommon.
	• Neurologic manifestations of anaplasmosis are uncommon.
	• Ehrlichiosis presents similarly to Rocky Mountain spotted fever, with nonspecific symptoms. Rash is more common in ehrlichiosis than in anaplasmosis.
	• Neurologic symptoms and signs are more common in ehrlichiosis than in anaplasmosis. The main neurologic complications of ehrlichiosis are meningitis and meningovasculitis.
	• African tick bite fever presents similarly to Rocky Mountain spotted fever, but an inoculation eschar is unique to this disease.
	• Neurologic complications of African tick bite fever are uncommon, and the illness is usually mild.
	• Neurologic complications of murine typhus are uncommon, and the illness is usually mild.
	• Neurologic complications of epidemic typhus are very common, including seizures, confusion, delirium and coma, meningitis, and meningoencephalitis.
	• About a quarter of patients with scrub typhus will have neurologic complications, including altered sensorium, seizures, meningitis, and meningoencephalitis.
	• Acute and often reversible hearing loss is seen in patients with Rocky Mountain spotted fever, murine typhus, epidemic typhus, and scrub typhus.
	• Rocky Mountain spotted fever has the highest risk of death among the Rickettsia species.
	• Neurologic involvement in all rickettsial infections is associated with poorer prognosis and possible lifelong impairment.
	• Better survival and neurologic outcomes are seen when treatment is started early.

Rocky Mountain spotted fever. In the United States, Dermacentor variabilis (dog tick) is the vector for most cases of Rocky Mountain spotted fever. This tick is found in the Eastern and Central parts of the United States as well as the Pacific Coast. D andersoni (wood tick) is the vector in the Western United States. Rhipicephalus sanguineus (brown dog tick) is a vector in parts of Arizona, Southern California, along the US–Mexico border, and in Mexico (06). Several species of Amblyomma ticks are the vector of Rocky Mountain spotted fever in Mexico and Argentina (06).

Symptoms of Rocky Mountain spotted fever typically begin 3 to 12 days after the bite of an infected tick; the incubation period is shorter in individuals with severe disease (06). Early symptoms of Rocky Mountain spotted fever are nonspecific and include high fever, headache, myalgias, and gastrointestinal symptoms. The characteristic rash begins 2 to 4 days after the onset of fever, but most patients present for care before rash onset; the classic triad of tick bite, rash, and fever is uncommon at first presentation (06). The rash begins as pink, blanching or nonblanching macules on the wrists and ankles and progresses to a maculopapular rash on the torso.

Characteristic rash on the distal extremities

Examples of an early-stage rash in a Rocky Mountain spotted fever patient. (Used with permission from: Centers for Disease Control and Prevention. Available at: www.cdc.gov/rmsf/symptoms/index.html.

The rash may subsequently become petechial or purpuric. In severe cases, it may be ecchymotic and necrotic, especially in distal areas, including the fingers, toes, nose, ears, and genitals (66). Rash is more common and occurs earlier in the disease course in children than in adults. According to the Tennessee Unexplained Encephalitis Project, the median time to rash after fever onset was 1 day in children and 15.5 days in adults; rash was seen in all children and in only half of the adults (10).

The main neurologic complications of Rocky Mountain spotted fever are meningoencephalitis and cerebral edema (02), and clinical findings include altered mental status, focal abnormalities, increased tone, and reflex abnormalities. Seizures were seen in 42% of patients in the Tennessee Unexplained Encephalitis Project (10). Focal neurologic deficits, including cranial or motor neuropathies, and sudden transient hearing loss have been described (06).

Common laboratory findings in Rocky Mountain spotted fever include thrombocytopenia, anemia, hyponatremia, and increases in serum concentrations of hepatic transaminases, bilirubin, and creatine kinase (66; 06). Peripheral white blood cell concentration may be normal, but there may be an increase in immature granulocytes (06).

Case fatality is 5% to 10% for spotted fever rickettsiosis and is higher for those treated more than 5 days after illness onset (17). In a review of published cases, 4% of patients treated within 5 days of illness onset died compared to 35% who were treated after 5 days (34). In addition to those with delayed treatment, children less than 10 years of age, adults 70 years old or older, and individuals with alcohol use disorder or immunosuppression are at the greatest risk of death from Rocky Mountain spotted fever (21). Persons with G6PD deficiency can have early fulminant disease, leading to death (06).

Long-term complications of Rocky Mountain spotted fever include cognitive impairment; hearing and vision loss; vestibular dysfunction; bowel and bladder abnormalities; speech, motor, and cerebellar dysfunction; and seizures (06). In a study of 80 hospitalized individuals with Rocky Mountain spotted fever in Arizona between 2002 and 2017, 17 (21%) died (26). Fifty-four of 63 survivors were impaired at hospital discharge based on modified Rankin score. Forty patients were interviewed after discharge, and nine of them underwent neurologic examination. Nine (23%) had persistent neurologic deficits, most commonly cognitive impairment. Some individuals with subsequent neurologic sequelae were reportedly normal at hospital discharge. The odds of neurologic sequelae were 19 times higher in patients who initiated doxycycline after day 5 of illness.

Anaplasmosis. Anaplasma phagocytophilum is transmitted by Ixodes scapularis ticks in the Northeast and Midwest United States and by Ixodes pacificus ticks on the West Coast. It is transmitted by I ricinus in Europe and by I persulcatus in Asia. The organism has an affinity for granulocytes, and it may also infect endothelial cells (57). Anaplasma can be transmitted by blood transfusion and organ transplantation, and infection may be more severe in these instances (49). The incubation period is 5 to 14 days (06). Symptoms are nonspecific and mimic those of Rocky Mountain spotted fever, including fever, headache, fatigue, arthralgia, and myalgia. However, contrary to Rocky Mountain spotted fever, rash is not typically seen. Neurologic manifestations are less common in anaplasmosis than in ehrlichiosis (06; 33). Confusion is the most common neurologic manifestation of infection (68). Young and Klein reported a patient who had both anaplasmosis and ehrlichiosis, with encephalopathy and frequent focal seizures (72). Stroke and cerebral vasospasm have been reported (40; 28; 50). Peripheral nervous system involvement, including brachial plexopathy; cranial nerve palsies, including bilateral facial palsy; and demyelinating polyneuropathy have been described in patients with anaplasmosis (33). Because of the overlap in tick vectors, concomitant infections with A phagocytophilum and B burgdorferi or Babesia microti in the United States (65; 33) or concomitant infection with A phagocytophilum and tick-borne encephalitis virus or B garinii in Europe (43; 44) have been reported.

Common laboratory findings in anaplasmosis include leukopenia, thrombocytopenia, and elevated serum levels of hepatic transaminases.

The case fatality rate is 0.3% in anaplasmosis (45). As with spotted fever rickettsioses, the elderly and those with underlying immunocompromise have poorer outcomes and are at the highest risk of death (06).

Ehrlichiosis. Ehrlichia chaffeensis is transmitted by Amblyomma americanum, the lone star tick (06), and this bacterium primarily infects monocytes. Ehrlichia chaffeensis infection is mostly seen in the Southeast, South Central, and mid-Atlantic United States, where the vector is endemic. Anaplasma can also be transmitted by blood transfusion and organ transplantation, and infection may be more severe in these instances (49). The incubation period is 5 to 14 days (06). Clinical symptoms of ehrlichiosis are nonspecific and mimic those of Rocky Mountain spotted fever and anaplasmosis, including fever, myalgia, headache, malaise, arthralgia, and nausea. Maculopapular, petechial, or red rashes are more common in ehrlichiosis than in anaplasmosis; they occur in up to 30% of patients, more commonly in children than in adults (65; 06; 33).

Ehrlichiosis is a more severe disease than anaplasmosis, and neurologic symptoms and signs are more common in ehrlichiosis than in anaplasmosis. Meningitis or meningovasculitis is seen in 20% of patients with ehrlichiosis (27). Other neurologic abnormalities include stupor and coma, hallucinations, seizures, and cranial nerve palsies (27).

Laboratory abnormalities in ehrlichiosis are similar to those of anaplasmosis, including leukopenia, thrombocytopenia, and increased serum concentration of hepatic transaminases.

The case fatality rate is 3% in ehrlichiosis (65). As with spotted fever rickettsioses, the elderly and those with underlying immunocompromise have poorer outcomes and are at the highest risk of death from ehrlichiosis (06). Children less than 10 years old have the highest case fatality rate for ehrlichiosis (06).

African tick bite fever. Rickettsia africae is transmitted by Amblyomma ticks, and it is endemic in sub-Saharan Africa, the Caribbean, and Oceana. It is the most common cause of rickettsial disease in travelers, where it occurs in clusters (37; 20). Clinical symptoms typically develop 5 to 7 days after a tick bite but may take up to 10 days to develop (37). The clinical presentation mimics many of the manifestations of Rocky Mountain spotted fever, including fever, headache, and myalgia. Regional lymphadenitis and aphthous stomatitis may also be seen. Neck muscle pain with subjective stiffness is common, as it is in Rocky Mountain spotted fever (37). Unlike Rocky Mountain spotted fever, one or more inoculation eschars, which are characterized by a black crust surrounded by erythema, are a unique finding. Macular, papular, or vesicular rash near the eschar (37) is seen in about 40% of patients (58). The disease course is generally mild. Neurologic complications include neuropsychiatric symptoms in adults and encephalopathy in infants (58). Subacute neuropathy is described as a complication in a small series (36).

Murine typhus. Murine typhus is most often a mild disease, with gradual onset of fever, myalgia, headache, maculopapular rash, hepatitis, and thrombocytopenia 7 to 14 days after exposure (18). Neurologic complications are uncommon, occurring in about 2% of patients, usually during the second week of illness (62). These include change in mental status, focal neurologic signs, papilledema with or without elevated CSF pressure, seizures, and aseptic meningitis or meningoencephalitis (64). Meningitis and meningoencephalitis can occur in the absence of other symptoms or signs of murine typhus (46). As with other rickettsial diseases, transient hearing loss may be seen (67).

Little information is known about neurologic outcomes after murine typhus. Neurologic deficits are considered rare, even in untreated disease (14).

Epidemic typhus. Epidemic typhus is characterized by 1 to 3 days of malaise, followed by abrupt onset of fever, severe headache, maculopapular or petechial rash, myalgia, hepatitis, and thrombocytopenia 8 to 16 days after exposure (18). Patients with epidemic typhus frequently have neurologic complications, including seizures, confusion, delirium, and coma (52; 05). Meningitis or meningoencephalitis may occur (47). Deafness is common, but it is often reversible (30). Symptoms and signs are generally less severe in infection associated with exposure to flying squirrels and in Brill-Zinsser disease.

Mortality of epidemic typhus is greatest in those over 60 years of age (05). Little information is known about neurologic outcomes after epidemic typhus. In a study from Ethiopia, adverse neurologic outcomes after epidemic typhus were rare (52).

Scrub typhus. Scrub typhus can range in severity from mild to severe, depending on the infecting strain. Abrupt onset of fever and chills, headache, myalgia, lymphadenopathy, altered mental status, and thrombocytopenia and abnormal levels of liver transaminases, bilirubin, and creatinine are seen 7 or more days after exposure. One or more eschars at the sites of chigger bites may be seen. A macular or maculopapular rash may develop in up to 50% of patients (05; (18).

A wide variety of neurologic abnormalities have been attributed to scrub typhus, including acute and reversible hearing loss (04). A prospective study of 189 patients with scrub typhus in Southern India identified headache, altered sensorium, and seizures as the most common neurologic symptoms or signs; 39 individuals had aseptic meningitis (09). Scrub typhus is a common cause of meningoencephalitis in endemic areas. In two large prospective studies of children with clinically defined meningoencephalitis or acute encephalitis syndrome in Southern India, about 24% had scrub typhus (03; 23). Similarly, in a study of 254 patients of all ages with bacterial or fungal CNS infections in Laos, O tsutsugamushi was responsible for 12% (25).

Little information is known about neurologic outcomes after scrub typhus. The median mortality of treated scrub typhus is 1.4%, but mortality is higher in those with CNS involvement (25). One study showed that 90% of children with scrub typhus meningoencephalitis had good overall performance at discharge (03).

Biological basis

	• The gram-negative Rickettsia species and related organisms are obligate intracellular pathogens.
	• Rickettsia rickettsii is a member of the spotted fever group of rickettsia, and it is the etiologic agent for Rocky Mountain spotted fever.
	• Rickettsia africanus is a member of the spotted fever group of rickettsia, and it is the etiologic agent for African tick bite fever.
	• Anaplasma phagocytophilum is the etiologic agent for anaplasmosis.
	• Ehrlichia chaffeensis is the most common etiologic agent for ehrlichiosis.
	• Rickettsia typhi is a member of the typhus group of rickettsia, and it is the etiologic agent for murine typhus.
	• Rickettsia prowazekii is a member of the typhus group of rickettsia, and it is the etiologic agent for epidemic typhus.
	• Orientia tsutsugamushi (formerly Rickettsia tsutsugamushi) is the most common etiologic agent for scrub typhus.
	• Interaction with target cells leads to secretion of proinflammatory cytokines and chemokines and recruitment of inflammatory cells. This inflammation is the main driver of pathogenicity.

Etiology and pathogenesis

The gram-negative Rickettsiales, which include Rickettsia species, Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Orientia tsutsugamushi are obligate intracellular pathogens. They have reduced genomes, having lost the genes required to live outside of host cells (60). They grow and replicate in endothelial and vascular smooth muscle cell cytoplasm and cause a lymphohistiocytic vasculitis (37; 19). The infection is cytopathic, which can cause capillary leakage and systemic volume depletion.

A phagocytophilum and E chaffeensis have two intracellular forms: dense core cells and reticulate cells. Dense core cells are infectious and transform into reticulate cells that reside inside a membrane vacuole in the host cell. These vacuoles filled with bacteria are the morulae characteristic of infection. Unlike rickettsia, A phagocytophilum, E chaffeensis, and O tsutsugamushi lack lipopolysaccharide and peptidoglycan, which helps them to evade host innate immune responses (33; 24).

Interaction with target cells, be it vascular endothelium or leukocytes, leads to the secretion of proinflammatory cytokines and chemokines and recruitment of inflammatory cells. This inflammation is the main driver of pathogenicity (37; 60; 39). Excessive macrophage activation may lead to secondary hematophagocytic lymphohistiocytosis (HLH) in patients with anaplasmosis and ehrlichiosis, which may resolve with antibiotic therapy alone (51; 61). Although this complication is uncommon in anaplasmosis, it may occur in at least 16% of individuals with ehrlichiosis (51; 13). Hematophagocytic lymphohistiocytosis is reported in individuals with spotted fever rickettsiosis (32), as well as murine typhus (31) and scrub typhus (70).

Epidemiology

	• As of 2010, cases of Rocky Mountain spotted fever in the United States are reported under the category of spotted fever rickettsioses.
	• In the United States, spotted fever rickettsiosis is most commonly reported in Arkansas, Missouri, North Carolina, Tennessee, and Oklahoma.
	• In the United States, anaplasmosis is most commonly reported in the upper Midwest and northeastern states.
	• In the United States, ehrlichiosis is most commonly reported in the South Central and southeastern states.
	• African tick bite fever is endemic to sub-Saharan Africa, the Caribbean, and Oceania. In the United States, it is seen in returning travelers.

Murine typhus occurs worldwide. Most cases of murine typhus in the United States occur in California, Hawaii, and Texas.

Louseborne epidemic typhus is uncommon in resource-rich settings, but outbreaks continue to occur worldwide where there is war, famine, displacement, and crowding. In the United States, cases of epidemic typhus are described in individuals exposed to flying squirrels and their nests.

Scrub typhus is endemic in Asia and the Western Pacific, with recent spread to the Middle East, South America, and Africa.

Rocky Mountain spotted fever. As of 2010, cases of Rocky Mountain spotted fever in the United States are reported under the category of spotted fever rickettsiosis because commonly available serological tests cannot distinguish between Rocky Mountain spotted fever and other rickettsial diseases that cause a similar illness (63). The reporting of all cases of rickettsial disease in the United States is passive, and its limitations should be acknowledged. Specifically, serological confirmation is required. A study using data from University of North Carolina Health showed that only 10% of individuals with suspected spotted fever group rickettsiosis underwent requisite acute and convalescent serological testing (see diagnostic workup below) (12). A study published in 2011 showed that the rate of reported Rocky Mountain spotted fever was as much as 11-fold higher in Native Americans than in whites (22). However, the odds of reporting Rocky Mountain spotted fever in Native Americans was almost 8-fold lower than in whites, likely reflecting limited access to health care and serological testing.

Limitations of surveillance aside, the number of reported cases of spotted fever rickettsiosis has increased over time (07; 17). However, the case fatality rate has decreased, perhaps because of the inclusion of spotted fever rickettsiosis infections caused by less virulent organisms compared to R rickettsii. Most cases are reported from April to September (06). The highest incidence of spotted fever rickettsiosis is in 60 to 69 year olds. The most recent data show that over half of the cases in the United States are reported from Arkansas, Missouri, and North Carolina (17). Spotted fever rickettsioses are endemic in several Native American communities in Arizona (06), where delays in diagnosis have likely led to high mortality (55). Similarly, a large outbreak of Rocky Mountain Spotted Fever is ongoing in Mexicali, Mexico, and surrounding regions, which primarily impacts low-income individuals (73). Recent increases in infections in Southern California have particularly impacted individuals who describe themselves as Hispanic or Latino and are likely related to the outbreak at the United States–Mexico border (41). The CDC issued a health advisory on December 8, 2023, regarding severe and fatal Rocky Mountain spotted fever in individuals who had traveled to Tecate, Mexico, which highlights the high fatality rate of Rocky Mountain spotted fever in Mexico.

Anaplasmosis. Anaplasmosis was first seen in Switzerland and in Slovenia in 1997. It is now widespread in Europe and is seen in Russia, China, and South Korea (45). Anaplasmosis has been reportable in the United States since 1999, and the number of cases has successively increased since then (15). Although cases are reported year-round, most occur in the summer, which corresponds to when the nymphal ticks are active. In the United States, anaplasmosis is most often reported in the upper Midwest and northeastern states. Cases are most commonly reported in men and in persons over 40 years of age (15).

Ehrlichiosis. As of 2008, cases of E chaffeensis infection are separately reportable to the United States Centers for Disease Control and Prevention. Although cases are reported throughout the year, most occur during the summer, with a peak in June and July. In the United States, E chaffeensis infections occur most frequently in the South Central and Eastern United States (16).

African tick bite fever. African tick bite fever is endemic in sub-Saharan Africa, the Caribbean, and Oceania. An estimated 3.6 billion people are at risk for infection with R africae (74).

Murine typhus. Murine typhus is caused by R typhi. Humans acquire infection by inoculating infected flea feces into the area of a flea bite, abraded skin, or mucous membranes or by inhalation of dust containing infected flea feces. Historically the Oriental rat flea is considered the vector, but in the United States the cat flea, found on cats, dogs, rats, and opossums, is the vector. Murine typhus occurs worldwide. A study from Laos showed that murine typhus was one of the three most common causes of bacterial CNS infections; the other two were leptospirosis and scrub typhus (25). Most cases of murine typhus in the United States occur in California, Hawaii, and Texas (01). Murine typhus is no longer a reportable disease in the United States.

Epidemic typhus. Epidemic typhus is caused by R prowazekii. Humans acquire infection by inoculating infected human body lice or their feces into non-intact skin, conjunctiva or mucous membranes, or by inhalation of dust containing infected louse feces. Although louseborne epidemic typhus is historically important with isolated outbreaks in crowded unsanitary settings, particularly during World War I, it is now an uncommon disease in resource-rich settings. Nonetheless, outbreaks continue to occur worldwide (54). In the United States, cases of epidemic typhus have been described in individuals exposed to flying squirrels and their nests (53). Epidemic typhus is no longer a reportable disease in the United States.

Scrub typhus. Scrub typhus is primarily caused by O tsutsugamushi. It is transmitted to humans by the bite of the parasitic larval chigger stage of Leptotrombidium mites. The organism is endemic in Asia and the Western Pacific, with recent spread to the Middle East, South America, and Africa (71). Surveillance data suggest that the incidence of scrub typhus is increasing, with both rural and urban populations affected (71).

Diagnostic workup

	• Diagnosis primarily relies on clinical findings and a high index of suspicion.
	• Polymerase chain reaction is the preferred test for diagnosis.
	• Acute and convalescent serological tests for IgG antibody can confirm the diagnosis but are not useful early in the disease.
	• Serological tests for spotted fever and typhus rickettsia cannot distinguish between species.
	• Mild CSF pleocytosis and elevated protein consistent with aseptic meningitis may be seen in Rocky Mountain spotted fever, ehrlichiosis, epidemic typhus, and scrub typhus.
	• A “starry sky” appearance on fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted magnetic resonance images is described primarily in children with Rocky Mountain spotted fever.

Diagnosis primarily relies on clinical findings, and empiric therapy should be initiated if rickettsial or related infection is suspected, without waiting for laboratory confirmation. Diagnostic tests include examination of a Wright or Giemsa-stained smear of blood; bone marrow or CSF for morulae in ehrlichiosis and anaplasmosis; acute and convalescent IgG serology; polymerase chain reaction testing of whole blood, cerebrospinal fluid, or tissue (especially for the rickettsioses), including the eschar of African tick bite fever and scrub typhus; and immunohistochemical staining of tissue. Although possible, culture is rarely performed.

Polymerase chain reaction is the preferred test because it can provide species-specific results quickly. Polymerase chain reaction should be performed in the first week of illness, ideally before or within 48 hours of antibiotic administration, when the yield is highest.

Immunofluorescent serological tests (IFAs) are used later in illness because they are more likely to be positive 2 to 4 weeks after the onset of symptoms. IgG antibodies are more specific than IgM antibodies, and a single reactive or nonreactive test is not diagnostic. The best way to use serological assays is to test together acute and convalescent serum samples collected 2 to 4 weeks apart. IFA serological tests cross-react within and between the spotted fever and typhus group organisms, and speciation is generally only available in reference laboratories (63).

In Rocky Mountain spotted fever, CSF may show very mild mononuclear pleocytosis and slightly elevated protein. Occasionally, the CSF glucose concentration may be low (10). Cerebrospinal fluid abnormalities are identified in 60% of patients with ehrlichiosis who have neurologic abnormalities, most commonly a mild (< 100 cells/ul) lymphocytic pleocytosis, although CSF cells may be neutrophils in 23% of individuals (27; 33). Morulae may uncommonly be identified in CSF monocytes (33). CSF findings consistent with aseptic meningitis can also be seen in epidemic typhus and scrub typhus. In addition to PCR, CSF IgM may be useful for diagnosing scrub typhus meningitis (03).

Neuroimaging in Rocky Mountain spotted fever may show meningeal enhancement, cerebral infarctions, cerebral edema, or prominent perivascular spaces (08). A “starry sky” appearance on fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted magnetic resonance images is described primarily in children with Rocky Mountain spotted fever but may also be seen in adults (35). This imaging finding is likely due to small perivascular and deep white matter infarcts (42; 11; 10; 35).

Management

	• Doxycycline is the treatment of choice for all patients with rickettsial and related diseases, regardless of age or pregnancy.
	• Treatment should be given empirically in the appropriate clinical setting without waiting for laboratory confirmation.

Doxycycline is the treatment of choice for all patients with rickettsial and related diseases, regardless of age or pregnancy, and it should be given empirically in the appropriate clinical setting without waiting for laboratory confirmation. Moreover, a 1988 report of Rocky Mountain spotted fever acquired in the Bronx in New York, a nonendemic area, serves as a reminder that rickettsial disease should be suspected in any patient with an unexplained febrile illness given the ease of treatment and the risk of a poor outcome if treatment is delayed (59).

Recommended doxycycline dosages are 100 mg every 12 hours for adults and 2.2 mg/kg body weight twice a day for children under 45 kg up to a maximum of 100 mg every 12 hours. Doxycycline administration should continue until at least 3 days after fever resolves and clinical improvement is achieved, generally for 7 to 10 days (06; 15; 16; 17; 18) Azithromycin, rifampin, and chloramphenicol are also effective treatments for scrub typhus and could be considered in the setting of severe tetracycline allergy. Rifampin should be considered as a second-line option after exclusion of a diagnosis of tuberculosis (29). Given the possible adverse events associated with chloramphenicol, it should likely also not be considered a first-line option. Treatment should be given for 10 days in patients with anaplasmosis because of the likelihood of concomitant B burgdorferi infection (06).

References

01: Alarcon J, Sanosyan A, Contreras ZA, et al. Fleaborne typhus-associated deaths - Los Angeles County, California, 2022. MMWR Morb Mortal Wkly Rep 2023;72(31):838-43. PMID 37535465
02: Anonymous. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 32-1997. A 43-year-old woman with rapidly changing pulmonary infiltrates and markedly increased intracranial pressure. N Engl J Med 1997;337(16):1149-56. PMID 9329937
03: Baidya A, Gunasekaran D, Dhodapkar R, Parameswaran N, Kaliaperumal V. Prevalence, clinico-laboratory features, and the functional outcome of children with scrub typhus meningoencephalitis-a cohort study. J Trop Pediatr 2022;68(5):fmac077. PMID 36150144
04: Basu S, Chakravarty A. Neurological manifestations of scrub typhus. Curr Neurol Neurosci Rep 2022;22(8):491-8. PMID 35727462
05: Bechah Y, Capo C, Mege JL, Raoult D. Epidemic typhus. Lancet Infect Dis 2008;8(7):417-26.** PMID 18582834
06: Biggs HM, Behravesh CB, Bradley KK, et al. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis - United States. MMWR Recomm Rep 2016;65(2):1-44.** PMID 27172113
07: Bishop A, Borski J, Wang HH, et al. Increasing Incidence of Spotted Fever Group Rickettsioses in the United States, 2010-2018. Vector Borne Zoonotic Dis 2022;22(9):491-7.** PMID 36037000
08: Bonawitz C, Castillo M, Mukherji SK. Comparison of CT and MR features with clinical outcome in patients with Rocky Mountain spotted fever. AJNR Am J Neuroradiol 1997;18(3):459-64. PMID 9090403
09: Boorugu H, Chrispal A, Gopinath KG, et al. Central nervous system involvement in scrub typhus. Trop Doct 2014;44(1):36-7. PMID 24226290
10: Bradshaw MJ, Byrge KC, Ivey KS, Pruthi S, Bloch KC. Meningoencephalitis due to spotted fever rickettsioses, including Rocky Mountain spotted fever. Clin Infect Dis 2020;71(1):188-95.** PMID 31412360
11: Bradshaw MJ, Lalor KB, Vu N, Pruthi S, Bloch KC. Child neurology: Rocky Mountain spotted fever encephalitis. Neurology 2017;88(11):e92-5.** PMID 28289173
12: Brown Marusiak A, Hollingsworth BD, Abernathy H, et al. Patterns testing for tick-borne diseases and implications for surveillance in the southeastern US. JAMA Netw Open 2022;5(5):e2212334.** PMID 35576005
13: Cabler SS, Hogan PG, Fritz SA, Bednarski JJ, Hunstad DA. Incidence and treatment of hemophagocytic lymphohistiocytosis in hospitalized children with Ehrlichia infection. Pediatr Blood Cancer 2020;67(10):e28436. PMID 32706439
14: Carr SB, Bergamo DF, Emmanuel PJ, Ferreira JA. Murine typhus as a cause of cognitive impairment: case report and a review of the literature. Pediatr Neurol 2014;50(3):265-8. PMID 24321542
15: Centers for Disease Control and Prevention. Anaplasmosis. Available at: https://www.cdc.gov/anaplasmosis/site.html. Accessed 2023a.
16: Centers for Disease Control and Prevention. Ehrlichiosis. Available at: https://www.cdc.gov/ehrlichiosis/site.html. Accessed 2023b.
17: Centers for Disease Control and Prevention. Rocky Mountain spotted fever (RMSF). Available at: https://www.cdc.gov/rocky-mountain-spotted-fever/site.html. Accessed 2023c.
18: Centers for Disease Control and Prevention. Clinical Overview of Typhus Fevers. Available at: https://www.cdc.gov/typhus/hcp/clinical-overview/index.html. Accessed 2024.
19: Chen LF, Sexton DJ. What's new in Rocky Mountain spotted fever? Infect Dis Clin North Am 2008;22(3):415-32, vii-viii. PMID 18755382
20: Cherry CC, Denison AM, Kato CY, Thornton K, Paddock CD. Diagnosis of spotted fever group rickettsioses in U.S. travelers returning from Africa, 2007-2016. Am J Trop Med Hyg 2018;99(1):136-42.** PMID 29848404
21: Dahlgren FS, Holman RC, Paddock CD, Callinan LS, McQuiston JH. Fatal Rocky Mountain spotted fever in the United States, 1999-2007. Am J Trop Med Hyg 2012;86(4):713-9. PMID 22492159
22: Dahlgren FS, Moonesinghe R, McQuiston JH. Short report: race and rickettsiae: a United States perspective. Am J Trop Med Hyg 2011;85(6):1124-5. PMID 22144456
23: Damodar T, Singh B, Prabhu N, et al. Association of scrub typhus in children with acute encephalitis syndrome and meningoencephalitis, Southern India. Emerg Infect Dis 2023;29(4):711-22. PMID 36957990
24: Diaz FE, Abarca K, Kalergis AM. An update on host-pathogen interplay and modulation of immune responses during Orientia tsutsugamushi infection. Clin Microbiol Rev 2018;31(2):e00076-17. PMID 29386235
25: Dittrich S, Rattanavong S, Lee SJ, et al. Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study. Lancet Glob Health 2015;3(2):e104-12.** PMID 25617190
26: Drexler NA, Close R, Yaglom HD, et al. Morbidity and functional outcomes following Rocky Mountain spotted fever hospitalization-Arizona, 2002-2017. Open Forum Infect Dis 2022;9(10):ofac506.** PMID 36324320
27: Dumler JS. Anaplasma and Ehrlichia infection. Ann N Y Acad Sci 2005;1063:361-73.** PMID 16481544
28: Eldaour Y, Hariri R, Yassin M. Severe anaplasmosis presenting as possible CVA: case report and 3-year Anaplasma infection diagnosis data is based on PCR testing and serology. IDCases 2021;24:e01073. PMID 33850717
29: El Sayed I, Liu Q, Wee I, Hine P. Antibiotics for treating scrub typhus. Cochrane Database Syst Rev 2018;9(9):CD002150. PMID 30246875
30: Friedmann I, Frohlich A, Wright A. Epidemic typhus fever and hearing loss: a histological study (Hallpike collection of temporal bone sections). J Laryngol Otol 1993;107(4):275-83. PMID 8320509
31: Iaria C, Colomba C, Di Carlo P, Scarlata F, Tolomeo M, Cascio A. Rickettsia typhi and haemophagocytic syndrome. Am J Trop Med Hyg 2017;97(5):1632. PMID 29140237
32: Ibarra Stone KA, Solis JG, Blanco-Lemus E, Malagon-Rangel J, Gordillo-Perez G. Spotted fever: an undercover cause of hemophagocytic lymphohistiocytosis in the immediate postpartum. Case Rep Infect Dis 2022;2022:3348393. PMID 35273815
33: Ismail N, McBride JW. Tick-borne emerging infections: ehrlichiosis and anaplasmosis. Clin Lab Med 2017;37(2):317-40.** PMID 28457353
34: Jay R, Armstrong PA. Clinical characteristics of Rocky Mountain spotted fever in the United States: a literature review. J Vector Borne Dis 2020;57(2):114-20.** PMID 34290155
35: Jena SS, Kar M, Soreng I, Acharrya S, Misra SR. Meningo-encephalitis due to spotted fever group rickettsia--a rare case report with serial follow up MRI. Neurol India 2022;70(1):412-4. PMID 35263931
36: Jensenius M, Fournier PE, Fladby T, et al. Sub-acute neuropathy in patients with African tick bite fever. Scand J Infect Dis 2006;38(2):114-8.** PMID 16449002
37: Jensenius M, Fournier PE, Kelly P, Myrvang B, Raoult D. African tick bite fever. Lancet Infect Dis 2003;3(9):557-64. PMID 12954562
38: Kelly DJ, Richards AL, Temenak J, Strickman D, Dasch GA. The past and present threat of rickettsial diseases to military medicine and international public health. Clin Infect Dis 2002;34(Suppl 4):S145-69. PMID 12016590
39: Kim HK. Rickettsia-host-tick interactions: knowledge advances and gaps. Infect Immun 2022;90(9):e0062121. PMID 35993770
40: Kim SW, Kim CM, Kim DM, Yun NR. Manifestation of anaplasmosis as cerebral infarction: a case report. BMC Infect Dis 2018;18(1):409. PMID 30119642
41: Kjemtrup AM, Padgett K, Paddock CD, et al. A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes. PLoS Negl Trop Dis 2022;16(9):e0010738. PMID 36108065
42: Kontzialis M, Zamora CA. Teaching NeuroImages: starry-sky appearance in Rocky Mountain spotted fever. Neurology 2015;85(12):e93. PMID 26391418
43: Lotric-Furlan S, Petrovec M, Avsic-Zupanc T, Strle F. Concomitant tickborne encephalitis and human granulocytic ehrlichiosis. Emerg Infect Dis 2005;11(3):485-8. PMID 15757574
44: Lotric-Furlan S, Ruzic-Sabljic E, Strle F. Concomitant human granulocytic anaplasmosis and Lyme neuroborreliosis. Clin Microbiol Infect 2009;15 Suppl 2:28-9. PMID 19416290
45: Madison-Antenucci S, Kramer LD, Gebhardt LL, Kauffman E. Emerging tick-borne diseases. Clin Microbiol Rev 2020;33(2):e00083.** PMID 31896541
46: Masalha R, Merkin-Zaborsky H, Matar M, Zirkin HJ, Wirguin I, Herishanu YO. Murine typhus presenting as subacute meningoencephalitis. J Neurol 1998;245(10):665-8. PMID 9776466
47: Massung RF, Davis LE, Slater K, McKechnie DB, Puerzer M. Epidemic typhus meningitis in the southwestern United States. Clin Infect Dis 2001;32(6):979-82. PMID 11247722
48: McDade JE, Shepard CC, Redus MA, Newhouse VF, Smith JD. Evidence of Rickettsia prowazekii infections in the United States. Am J Trop Med Hyg 1980;29(2):277-84. PMID 6154428
49: Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV. Ehrlichiosis and anaplasmosis among transfusion and transplant recipients in the United States. Emerg Infect Dis 2021;27(11):2768-75. PMID 34670661
50: Mullholand JB, Tolman N, De Obaldia A, Hennrikus E. Central nervous system involvement of anaplasmosis. BMJ Case Rep 2021;14(12):e243665. PMID 34880034
51: Otrock ZK, Eby CS, Burnham CD. Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. Blood Cells Mol Dis 2019;77:17-22. PMID 30913447
52: Perine PL, Chandler BP, Krause DK, et al. A clinico-epidemiological study of epidemic typhus in Africa. Clin Infect Dis 1992;14(5):1149-58. PMID 1600020
53: Prusinski MA, White JL, Wong SJ, et al. Sylvatic typhus associated with flying squirrels (Glaucomys volans) in New York State, United States. Vector Borne Zoonotic Dis 2014;14(4):240-4. PMID 24689928
54: Raoult D, Roux V, Ndihokubwayo JB, et al. Jail fever (epidemic typhus) outbreak in Burundi. Emerg Infect Dis 1997;3(3):357-60. PMID 9284381
55: Regan JJ, Traeger MS, Humpherys D, et al. Risk factors for fatal outcome from rocky mountain spotted fever in a highly endemic area-Arizona, 2002-2011. Clin Infect Dis 2015;60(11):1659-66. PMID 25697742
56: Ricketts H. The study of “Rocky Mountain spotted fever” (tick fever) by means of animal inoculations. JAMA 1906;47:33-6.
57: Rikihisa Y. Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum. Clin Microbiol Rev 2011;24(3):469-89. PMID 21734244
58: Roch N, Epaulard O, Pelloux I, et al. African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. Clin Infect Dis 2008;47(3):e28-35. PMID 18558881
59: Salgo MP, Telzak EE, Currie B, et al. A focus of Rocky Mountain spotted fever within New York City. N Engl J Med 1988;318(21):1345-8. PMID 3130574
60: Salje J. Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle. Nat Rev Microbiol 2021;19(6):375-90.** PMID 33564174
61: Scribner J, Wu B, Lamyaithong A, Arcega V, Villanueva DD. Anaplasmosis-induced hemophagocytic lymphohistiocytosis: a case report and review of the literature. Open Forum Infect Dis 2023;10(5):ofad213. PMID 37213427
62: Silpapojakul K, Ukkachoke C, Krisanapan S, Silpapojakul K. Rickettsial meningitis and encephalitis. Arch Intern Med 1991;151(9):1753-7. PMID 1888241
63: Stewart AG, Stewart AGA. An update on the laboratory diagnosis of Rickettsia spp infection. Pathogens 2021;10(10):1319.** PMID 34684267
64: Talhelm CF, Helms JL, Tran LT, et al. Rickettsia typhi central nervous system infection. IDCases 2020;21:e00852. PMID 32509531
65: Thomas RJ, Dumler JS, Carlyon JA. Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis. Expert Rev Anti Infect Ther 2009;7(6):709-22. PMID 19681699
66: Thorner AR, Walker DH, Petri WA Jr. Rocky mountain spotted fever. Clin Infect Dis 1998;27(6):1353-9. PMID 9868640
67: Tsiachris D, Deutsch M, Vassilopoulos D, Zafiropoulou R, Archimandritis AJ. Sensorineural hearing loss complicating severe rickettsial diseases: report of two cases. J Infect 2008;56(1):74-6. PMID 18023483
68: Weil AA, Baron EL, Brown CM, Drapkin MS. Clinical findings and diagnosis in human granulocytic anaplasmosis: a case series from Massachusetts. Mayo Clin Proc 2012;87(3):233-9.** PMID 22386178
69: Wolbach SB. Studies on Rocky Mountain spotted fever. J Med Res 1919;41(1):1-198.41. PMID 19972499
70: Wu H, Xiong X, Zhu M, Zhuo K, Deng Y, Cheng D. Successful diagnosis and treatment of scrub typhus associated with haemophagocytic lymphohistiocytosis and multiple organ dysfunction syndrome: a case report and literature review. Heliyon 2022;8(11):e11356. PMID 36411909
71: Xu G, Walker DH, Jupiter D, Melby PC, Arcari CM. A review of the global epidemiology of scrub typhus. PLoS Negl Trop Dis 2017;11(11):e0006062. PMID 29099844
72: Young NP, Klein CJ. Encephalopathy with seizures having PCR-positive Anaplasma phagocytophilum and Ehrlichia chaffeensis. Eur J Neurol 2007;14(2):e3-4. PMID 17250712
73: Zazueta OE, Armstrong PA, Marquez-Elguea A, et al. Rocky Mountain spotted fever in a large metropolitan center, Mexico-United States border, 2009-2019. Emerg Infect Dis 2021;27(6):1567-76.** PMID 34014151
74: Zhang YY, Sun YQ, Chen JJ, et al. Mapping the global distribution of spotted fever group rickettsiae: a systematic review with modelling analysis. Lancet Digit Health 2023;5(1):e5-15. PMID 36424337
75: References especially recommended by the author or editor for general reading.

Contributors

All contributors' financial relationships have been reviewed and mitigated to ensure that this and every other article is free from commercial bias.

Author

Christina M Marra MD

Dr. Marra of the University of Washington School of Medicine has no relevant financial relationships to disclose.
See Profile

Editor

John E Greenlee MD

Dr. Greenlee of the University of Utah School of Medicine has no relevant financial relationships to disclose.
See Profile

Former Authors

Victoria Cegielski

Patient Profile

Age range of presentation: African tick bite fever

Typical: All ages

Anaplasmosis

Typical: Greater than 40 years

Ehrlichiosis

Typical: 60 to 69 years

Epidemic typhus

Typical: All ages; mortality greatest in those over 60 years of age

Murine typhus

Typical: All ages

Scrub typhus

Typical: All ages; most common cause of meningoencephalitis in endemic areas

Spotted fevers

Typical: Greater than 40 years; death rate highest in those younger than 10 years
Sex preponderance: Anaplasmosis

Male > Female

Ehrlichiosis

Male > Female

Spotted fevers

Male > Female
Population groups selectively affected: African tick bite fever

People returning from international travel to endemic areas

Scrub typhus

People returning from international travel to endemic areas
Occupation groups selectively affected: People who work outdoors in areas in which the tick, flea, or mite vector is present are at risk for spotted fever group rickettsiosis, anaplasmosis, ehrlichiosis, endemic typhus, and scrub typhus.

People who harbor human body lice and those in close contact with them are at risk for epidemic typhus.

People exposed to flying squirrels or their nests in the United States are at risk for epidemic typhus.

ICD & OMIM codes

ICD-10: African tick bite fever: A77.8

Anaplasmosis: A79.82

Ehrlichiosis: A77.41

Rocky Mountain spotted fever: A77.0

Spotted fevers: A77.9
ICD-11: Spotted fever due to Rickettsia rickettsii: 1C31.0

Spotted fever due to Rickettsia conorii: 1C31.1

Spotted fever due to Rickettsia sibirica: 1C31.2

Spotted fever due to Rickettsia australis: 1C31.3

Other specified spotted: 1C31.Y

Spotted fever, unspecified: 1C31.Z

Rickettsialpox: 1C32

Other specified rickettsioses: 1C3Y

Other specified arthropod-borne viral fevers: 1D4Y

Harmful effects of or exposure to noxious substances, chiefly nonmedicinal as to source, not elsewhere classified: NE61

Special screening examination for other bacterial diseases: QA08.2

This is an article preview.
Start a Free Account
to access the full version.

Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Listen to MedLink on the go with Audio versions of each article.

Questions or Comment?

MedLink®, LLC

3525 Del Mar Heights Rd, Ste 304
San Diego, CA 92130-2122

Toll Free (U.S. + Canada): 800-452-2400

US Number: +1-619-640-4660

Support: service@medlink.com

Editor: editor@medlink.com

ISSN: 2831-9125

Central nervous system infection with Rickettsia species and related organisms

Differential Diagnosis

bacterial sepsis
meningococcemia
measles
secondary syphilis
idiopathic thrombocytopenic purpura
- leptospirosis
- infectious mononucleosis
- viral encephalitis
- tuberculous meningitis
- babesiosis
- HIV
- Lyme disease
- malaria
- typhoid
- dengue
- chikungunya
- other tropical fevers.

CNS infection with rickettsia species and related organisms …

Central nervous system infection with Rickettsia species and related organisms

Introduction

Overview

Key points

Historical note and terminology

Clinical manifestations

Presentation and course

Biological basis

Etiology and pathogenesis

Epidemiology

Prevention

Differential diagnosis

Confusing conditions

Diagnostic workup

Management

Special considerations

Pregnancy

Media

References

Contributors

Author

Editor

Former Authors

Patient Profile

ICD & OMIM codes

This is an article preview.
Start a Free Account
to access the full version.

Questions or Comment?

Also in This Category

Neuropathies associated with cytomegalovirus infection

Genital herpes: neurologic complications

Zika virus: neurologic complications

Gram-negative bacillary meningitis

Pneumococcal meningitis

HTLV-1 associated myelopathy

Infective endocarditis

Japanese encephalitis

	• No vaccines exist for rickettsial and related infections.
	• Prevention relies on limiting exposure to vectors.

Central nervous system infection with Rickettsia species and related organisms

Introduction

Overview

Key points

Historical note and terminology

Clinical manifestations

Presentation and course

Biological basis

Etiology and pathogenesis

Epidemiology

Prevention

Differential diagnosis

Confusing conditions

Diagnostic workup

Management

Special considerations

Pregnancy

Media

References

Contributors

Author

Editor

Former Authors

Patient Profile

ICD & OMIM codes

This is an article preview. Start a Free Account to access the full version.

Questions or Comment?

Also in This Category

Neuropathies associated with cytomegalovirus infection

Genital herpes: neurologic complications

Zika virus: neurologic complications

Gram-negative bacillary meningitis

Pneumococcal meningitis

HTLV-1 associated myelopathy

Infective endocarditis

Japanese encephalitis

This is an article preview.
Start a Free Account
to access the full version.