Congenital cocaine syndrome …

General Child Neurology

Updated 04.30.2024
Released 11.28.1994
Expires For CME 04.30.2027

Congenital cocaine syndrome

Authors: Daniel J Bonthius MD PhD, Kaleb Mikami MD

See Contributor Disclosures

Editor: Ann Tilton MD

Congenital cocaine syndrome

In This Article

Quick Link

Introduction

Overview

Cocaine is one of the most addictive and frequently abused illicit drugs. Maternal abuse of cocaine during pregnancy is common and associated with a host of pregnancy complications. In the fetal brain, cocaine interacts with monoaminergic receptors, whereby it alters the physiology, structure, and survival of neurons and leads to long-term learning and behavior problems in prenatally exposed children.

Key points

	• Maternal cocaine abuse during pregnancy is common and associated with a host of neurologic and developmental abnormalities in the offspring.
	• Cocaine is a potent vasoconstrictor, and many of the medical and neurologic problems of children exposed to cocaine in utero are due to compromised blood flow through placental and cerebral vasculature.
	• Cocaine can interact with the monoaminergic synapses in the developing brain to induce short-term and long-term changes in neurophysiology and anatomy.
	• Cocaine can alter maternal behaviors, and cocaine can disrupt maternal-fetal interactions, which may contribute to the neurodevelopmental problems of the offspring.

Historical note and terminology

Cocaine is benzoylmethylecgonine, an alkaloid derived from the leaves of the coca shrub (Erythroxylon coca), which grows wild and is cultivated in South American and Central American countries (42). Cocaine is available either as cocaine hydrochloride or as the highly purified (free base form) cocaine alkaloid. Cocaine hydrochloride is water soluble but heat labile and is most commonly administered by nasal insufflation (“snorting”). In contrast, cocaine alkaloid is water insoluble but heat stable and is typically administered by inhalation (smoking). Because the alkaloid preparation produces a popping sound when the crystals are heated, it has acquired the name “crack.”

Considering cocaine’s widespread use among pregnant women, the effect of the drug on the fetus is an issue of major public health importance. It is widely accepted that cocaine can be deleterious to the fetus and that the fetal brain is particularly vulnerable. However, several factors have made the study of cocaine’s effects on the human fetus difficult to conduct and interpret.

Foremost among these difficulties is the inescapable fact that a cocaine-exposed fetus is often exposed to many additional deleterious confounding variables during prenatal and postnatal life (73; 78). A pregnant woman who abuses cocaine may also drink alcohol, smoke cigarettes, and abuse other illicit drugs. She may transmit to the fetus a congenital infection, such as HIV or syphilis. Following birth, the child of a cocaine-abusing mother may receive inadequate nutrition and grow up in a poor social environment (117).

During the 1980s, a plethora of papers described wide-ranging and highly negative outcomes among children exposed to cocaine in utero. The alarm sounded in the medical literature and lay press that an entire generation of deeply disabled “crack babies” was being produced. It later became evident that physicians, scientists, journalists, and politicians had overreacted in the face of the data and that cocaine did not necessarily have as profound and far-reaching consequences for the fetus as had been feared. This overreaction was due, in large part, to the failure of physicians and scientists to appreciate the many confounding variables accompanying fetal cocaine exposure. It is now appreciated that cocaine can damage a fetus, sometimes with permanent consequences, but that the damage is typically either circumscribed in nature or subtle in severity, and the impending onslaught of multiply injured crack babies is a myth (26; 27).

A second issue that has complicated the study of fetal cocaine exposure relates to the choice of outcome measure. Cocaine may adversely affect neural systems involved in complex neurologic and behavioral functions, such as motivation, attention, social interaction, and intelligence, which are difficult to measure, particularly during infancy. Because many children prenatally exposed to cocaine are in chaotic home environments, locating the children for long-term follow-up studies is often difficult.

A third methodological difficulty relates to accurately identifying the exposed fetuses and children and determining the degree and timing of the exposure. Because cocaine use is illegal and carries moral implications when used during pregnancy, women may lie about their use of the drug. Testing for cocaine metabolites in urine, meconium, amniotic fluid, umbilical cord tissue, and brain identifies some, but not all, exposed fetuses, and the issues of dose and timing of exposure remain. The nature and severity of the teratogenic and destructive effects of cocaine on the fetus probably depend on the gestational timing and magnitude of exposure (120; 38). Thus, the imprecise measure of these crucial variables has limited the ability to determine cocaine’s effect on the developing brain.

Clinical manifestations

Presentation and course

	• Cocaine use during pregnancy can cause serious maternal-fetal complications, including maternal hypertension and abruptio placentae.
	• Women who use cocaine tend to be less attentive to their babies and have other negative maternal behaviors.
	• Cocaine can cross the placenta and adversely affect fetal development, including impaired somatic growth.
	• Because it is a vasoconstrictor, cocaine can cause perinatal cerebral infarction in fetuses and neonates.
	• Prenatal cocaine exposure can lead to long-term neurodevelopmental abnormalities in offspring.

The clinical manifestations of intrauterine cocaine exposure fall into the following three major categories: (1) maternal-fetal effects, (2) physical and neurologic effects noted at birth, and (3) long-term behavioral consequences.

Maternal-fetal effects. Cocaine use during pregnancy can produce a variety of serious obstetrical complications, many of which are injurious to the developing fetus and dangerous to the mother. Cocaine can produce preterm delivery and premature and prolonged rupture of the membranes (114; 02). Additional cocaine-related complications in pregnancy include hypertensive crisis, spontaneous abortion, and abruptio placentae (01; 35; 05).

Cocaine use greatly increases the likelihood of maternal hypertension and the obstetric complications associated with that disorder. Cocaine dependence prior to pregnancy is strongly associated with hypertensive disorders of pregnancy, even if the woman abstains from cocaine use during the pregnancy. This ongoing predisposition to hypertension is believed to be due to heightened vascular reactivity to sympathetic/noradrenergic stimulation precipitated by the prior chronic cocaine exposure (94).

Cocaine is a potent vasoconstrictor that can compromise placental blood flow. Animal models have demonstrated that small doses of cocaine can substantially decrease uterine artery blood flow and increase uterine vascular resistance (88; 130). These changes can be accompanied by marked fetal hypoxemia, hypertension, and tachycardia. Following a single dose of cocaine, these effects typically persist for 15 minutes. Fetal acidosis and increased catecholamine levels induced by compromised uterine circulation may underlie the premature induction of labor.

Cocaine adversely affects not only the flow of blood through the placenta, but also the placenta itself. The vasoactive effects of cocaine can lead to placental infarctions and abruptions. These negative effects on placental integrity can have major and persistent effects on the fetus. In pregnancies complicated by cocaine exposure, the state of placental health has been significantly correlated with fetal outcome and with severity of withdrawal symptoms in the newborn (36).

The effects of cocaine on the mother and the secondary effects on the offspring occur both prenatally and postnatally (127). Cocaine addiction during pregnancy can disrupt the mother’s ability to care optimally for her child. Early dysfunctional mother-infant interactions probably contribute to adverse effects of prenatal cocaine exposure. Evidence has emerged that disruption of maternal oxytocin systems underlies this aberrant maternal behavior.

Cocaine-using women are less attentive and sensitive to infant cues. They show less interest and more hostility to their babies. Oxytocin is a neuropeptide released from the hypothalamus into the maternal blood stream in response to infant-produced stimuli. Both acute and chronic cocaine exposure can substantially alter maternal oxytocin signaling, and the effects can be long lasting. These changes in oxytocin signaling have been correlated with dysfunctional maternal behaviors, which have been correlated with aberrant social behaviors and diminished learning potential in the offspring. Thus, infants may suffer from alterations in maternal behavior that are mediated by cocaine-induced changes in maternal oxytocin signaling (127).

Prenatal cocaine can alter both placental and fetal physiology. Immediately following an acute maternal dose of cocaine, the fetus may manifest tachycardia, extreme baseline heart rate variability, and abnormal elevation of respiratory rate and tidal volume. The respiratory abnormalities noted in utero continue in the newborn period, possibly due to autonomic dysfunction, and may underlie the increased incidence of sudden infant death syndrome in prenatally exposed infants (124; 125; 24).

Exposed fetuses may also have withdrawal signs while in utero. Indeed, fetuses withdrawing from cocaine display symptoms similar to their withdrawing mothers, including irritability, repetitive yawning, and abnormal arousal. The disorganization of fetal behavior has been correlated with the magnitude of maternal cocaine use.

Until recently, it was unclear whether cocaine could directly affect the fetal brain or whether all effects were manifested through the fetal and placental vasculature. However, a study utilized PET to demonstrate that in third trimester pregnant nonhuman primates, cocaine at doses typically used by drug abusers significantly increased brain glucose metabolism (17). This finding, along with the known presence of functional monoaminergic synapses at which cocaine may exert its actions in the fetal brain, strongly suggests that cocaine is pharmacologically active in the human fetal brain (40).

Physical and neurologic effects at birth. Most infants exposed in utero to cocaine appear normal, at least on a standard newborn examination. However, maternal cocaine use during pregnancy can produce abnormalities detectable at birth in many exposed infants. These include abnormalities of morphology, physiology, and behavior.

Cocaine exposure during pregnancy can interfere with somatic growth of the fetus. As a result, newborns with prenatal cocaine exposure often have reduced birth weight and are small for gestational age (47). Maternal cocaine use decreases fetal somatic growth by nearly two thirds (63%) of a standard deviation (10). The potential public health impact of cocaine-induced intrauterine growth retardation is high because low birth weight is a key risk factor for infant morbidity and mortality (80).

Even more disturbing than its effect on somatic growth is cocaine’s deleterious effect on brain growth. Prenatal cocaine exposure is associated with microcephaly among the offspring of cocaine-abusing mothers. Furthermore, the severity of brain growth restriction may exceed body growth impairment, producing asymmetrical growth retardation with a brain-wasting pattern (69; 12).

Because mothers who abuse cocaine also expose their fetuses to other factors that can impair growth (such as tobacco smoking, other drugs, and undernutrition), the possibility exists that fetal growth disturbance is due to these confounding factors and not to cocaine per se. However, an animal study has demonstrated that maternal exposure to cocaine alone reduces fetal birth weight (20). Furthermore, although the fetal brain is selectively spared in undernutrition, it is particularly vulnerable in cocaine exposure, suggesting that microencephaly in cocaine-exposed newborns is due to the cocaine and not to undernutrition.

One of the most dramatic effects of acute cocaine exposure in the newborn period is perinatal cerebral infarction. A classic case report described an infant born at term following maternal cocaine use 15 hours before delivery (22). On admission to the hospital, the mother was disoriented and had slurred speech. At birth, the infant was tachycardiac and had a right-sided hemiparesis. Neuroimaging demonstrated a left posterior parietal infarction. Since this report, numerous cases have been published of cocaine-exposed infants with perinatal strokes.

In addition to inducing ischemic strokes in the perinatal period, cocaine also induces intracerebral hemorrhages in the neonate (113). In premature newborns, cocaine increases the risk of intraventricular hemorrhage (110). In both premature and full-term newborns, cocaine increases the incidence of subependymal hemorrhage and the formation of subependymal cysts (112).

Abnormal autonomic function is also seen in infants prenatally exposed to cocaine. Cocaine-exposed infants have less heart rate variability than do infants exposed to other drugs or unexposed infants (82). Newborns exposed to cocaine are also at increased risk for tachyarrhythmias including isolated atrial flutter (44). These abnormalities in heart rate variability and vagal tone often persist when the infants are retested at 2 to 6 months of age (81).

Heart rates in cocaine-exposed infants are abnormal not only at baseline but also in response to environmental changes. Newborns prenatally exposed to cocaine have a delayed and prolonged heart rate reaction to orthostatic stress (55). Furthermore, abnormalities in heart rate responses persist in 7-month-old infants during tasks that illicit positive or negative affect (107). These early autonomic changes are clinically relevant, as they may underlie the increased risk of SIDS in infants exposed to cocaine in utero (123; 37). Furthermore, they may signify later life cardiovascular problems. In experimental rodents, prenatal cocaine reprograms coronary myogenic tone, increases the risk of coronary autoregulatory dysfunction, and increases the incidence of cardiac events as adults (135; 132). Therefore, at least in experimental animals, early cocaine use may impact later cardiac health.

In addition to morphology and physiology, the neurobehavior of infants may also be altered by prenatal cocaine exposure. Singer and colleagues performed neurobehavioral assessments on infants heavily exposed, lightly exposed, or unexposed to cocaine in utero (109). They found that jitteriness, attention problems, tone abnormalities, and sensory asymmetries increased in a dose-response pattern. Additional studies have suggested that cocaine may increase other neurobehavioral abnormalities, including irritability, impaired interaction, poor habituation, and diminished arousal (25; 60; 13).

Newborns prenatally exposed to cocaine have a greatly increased incidence of prenatally acquired infection. Hepatitis, syphilis, and human immunodeficiency virus are all substantially more common among cocaine-exposed infants than among controls (13). However, prenatally exposed infants do not have a higher rate of postnatally acquired infections (45). Therefore, the increased incidence of infection in prenatally exposed infants likely represents a difference in maternal behavior, including exposure to sexually transmitted diseases, rather than an impaired immune response in the infant. Early recognition of these infections is important, as they are associated with increased morbidity and can substantially complicate the care of these already compromised newborns.

Thus, cocaine may induce a wide variety of physical, physiological, and behavioral abnormalities in the newborn. The extent to which each of these abnormalities is due to cocaine’s vasoactive properties, toxic effects, and pharmacologic effects remains unknown.

Long-term developmental effects. There are many reasons for presuming that prenatal cocaine impairs cognition and development, thus leading to permanent physical, mental, and emotional disabilities. Cocaine affects monoaminergic neurotransmitter systems important for the development of neuronal circuitry (120; 77). It can cause vasospasm of cerebral and umbilical arteries, thus leading to generalized and cerebral fetal ischemia. The drug has been linked to prematurity, premature rupture of membranes, microcephaly, low birthweight, and newborn behavioral abnormalities (12; 10; 47). All of these perinatal and neonatal complications are risk factors for adverse developmental outcomes.

Despite the preponderance of theoretical arguments that cocaine may cause permanent disabilities, evidence that cocaine actually does so was slow to emerge. Multiple studies conducted during the 1980s demonstrated long-term neurologic and behavioral manifestations of prenatal cocaine exposure. However, others failed to replicate the findings and argued that the apparent effects of prenatal cocaine exposure on children were due to confounding variables. It has become clear that cocaine has negative long-term developmental effects after the publication of multiple high-quality and well-controlled studies (70; 85).

This controversy regarding long-term neurodevelopmental sequelae of prenatal cocaine exposure has induced strong opinions and controversial actions within the medical, legal, and lay populations. For example, medical personnel have turned over the names of obstetric patients testing positive for cocaine metabolites to police, who have arrested the women for drug possession and child abuse (95). Community organizations have offered financial incentives to accept long-acting contraception and sterilization to women with a history of illegal drug use (93; 43). The popular press has fueled fear of an epidemic of “cocaine babies” and “crack kids” that are costly to society and impossible to educate (30; 126). No issue regarding fetal cocaine exposure has generated greater controversy than the issue of cocaine-induced neurodevelopmental sequelae.

Because of the controversy surrounding the long-term effects of prenatal cocaine exposure, Frank and colleagues conducted a meta-analysis examining the postnatal outcomes of children exposed to cocaine in utero (43). They examined five domains, including physical growth, cognition, language skills, motor skills, and behavior. After controlling for confounders, they found no strong evidence that prenatal cocaine exposure adversely impacts any of these domains outside of the neonatal period. These authors concluded that many adverse outcomes once attributed specifically to in utero cocaine exposure were actually due to other correlated factors, including prenatal exposure to alcohol and tobacco and a poor childhood environment.

Other studies, however, have found strong evidence that fetal cocaine exposure can specifically and substantially impair neurodevelopmental processes in children. In particular, Singer and colleagues prospectively studied a large cohort of cocaine-exposed infants born at a large urban county hospital (109). They compared the cocaine-exposed infants with unexposed infants from the same population. Using standardized normative measures of cognitive and motor development, they tested the children at two years of age and found substantial cognitive deficits among the cocaine-exposed children. The exposed children were twice as likely as the unexposed children to have developmental delay. Importantly, because the study design controlled for prenatal exposure to other drugs, gestational age and size at birth, and a variety of caregiver characteristics, many of the confounding variables that plagued earlier studies were eliminated. Thus, the cognitive deficits observed in the cocaine-exposed children probably were truly attributable to cocaine.

Likewise, prenatal cocaine exposure can have a negative and long-term impact on language skills. A longitudinal study from 4 months to 3 years of age revealed that cocaine-exposed children had poorer language skills than unexposed children (91). This longitudinal effect remained significant, even after elimination of potential confounding influences, including sociodemographic factors and prenatal exposure to other substances. A second longitudinal study confirmed that expressive and receptive language skills remain impaired at ages 4 and 6 years in children prenatally exposed to cocaine (66). Furthermore, children do not appear to outgrow these language deficits. A study conducted on late adolescents found that prenatal cocaine has a lasting negative impact on many language-related functions, including word reading, reading comprehension, semantic and grammatical processing, and expressive language (62; 97).

Additional studies have demonstrated that negative effects of prenatal cocaine exposure on neurodevelopment endure well into childhood. In utero exposure to cocaine reduces IQ and verbal reasoning scores (16), delays language development (33; 11; 66), increases the incidence of learning disabilities (92), impairs procedural learning (76), and impairs behavioral regulation and attention (50; 07) in preschool and school-aged children.

In addition to impairing cognitive and language development, prenatal cocaine exposure may also lead to aggressive behavior. Multiple animal studies have shown that prenatal cocaine disrupts social behaviors and leads to long-term increased aggression during stressful, competitive tasks (56; 57; 129).

Based on these results in animal models, Bendersky and colleagues examined the impact of prenatal cocaine exposure on childhood aggression (15). They found that prenatal cocaine exposure significantly increased aggressive behaviors at the age of five years, especially in boys and in children raised in poor home environments. Prenatal cocaine exposure is also associated with long-term increases in risk-taking behavior and substance use and abuse. Teenagers who were prenatally exposed to cocaine are twice as likely as nonexposed teens to use tobacco and marijuana and to have a substance use disorder at age 17 (86). The increased risk-taking may be due to long-term cocaine-induced deficits in the feedback processing that helps people to avoid consequences of negative behavior. Indeed, physiologic correlates of feedback-related negativity are decreased in adolescents who were prenatally exposed to cocaine (89).

The findings that prenatal cocaine exposure appears to permanently impair learning ability and behavioral control, led Rivkin and colleagues to examine whether cocaine permanently alters the size of the brain and its components (102). In a volumetric MRI study, these authors found that children 10 to 14 years of age who were prenatally exposed to cocaine had lower volumes of cortical gray matter and total parenchymal volumes than matched controls. The cocaine-exposed children also had smaller head circumferences. Furthermore, these adverse effects of cocaine on brain growth were exacerbated by prenatal exposure to alcohol, tobacco, and marijuana. These findings suggest that prenatal cocaine does permanently reduce brain volume and that the drug may act cumulatively with other abused substances to permanently impair brain size and volume.

The more time that passes after prenatal exposure, the more difficult it is to conduct a study examining the effects of that exposure. As a result, studies examining the effects of prenatal cocaine exposure on adolescents are few in number and tend to be small in scale. Despite these shortcomings, several well-controlled studies have demonstrated that prenatal cocaine exposure does have negative consequences that can be detected in adolescents. In particular, adolescents with prenatal cocaine exposure have a substantially increased likelihood of having impulsivity, aggression, and rule-breaking behavior (70; 85). Teenagers who were prenatally exposed to cocaine are also more likely to engage in early and risky sexual behavior (84). Teenagers with prenatal cocaine exposure have higher anxiety, likely mitigated by earlier and more frequent use of cannabis (90).

Research has also shown that prenatal cocaine exposure can have adverse behavioral effects that last into adulthood. A longitudinal study on the offspring of women recruited during pregnancy compared offspring exposed to cocaine with unexposed controls at multiple time points throughout life (99; 100). The research revealed an association between prenatal cocaine exposure and multiple adverse externalizing behaviors, including early drug use, emotional regulation problems, risky sexual behavior, and arrests. Prenatal cocaine exposure was associated with a two-fold risk of conduct disorder diagnosis by age 21, a two-fold risk of marijuana use at age 25, and a five-fold risk of an arrest history by age 25. Importantly, this study matched participants and controlled for a variety of confounding variables. Thus, the controlled data identified not only indirect associations between prenatal cocaine exposure and adult adverse behaviors that were impacted by adolescent adverse behaviors, but also identified true direct associations between prenatal cocaine exposure and adult adverse behaviors. These findings demonstrate that associations between prenatal cocaine exposure and later behaviors can persist into the early stages of adulthood and that cocaine may be a direct component of such behaviors (100).

Prenatal exposure to certain drugs can permanently alter the neural systems involved in drug addiction and lead to addictive behaviors later in life. For example, prenatal alcohol and tobacco exposure increases the risk of alcohol (08; 03) and tobacco use later in life (58; 28; 04). Animal studies have suggested that this same phenomenon may occur with cocaine. Experiments using laboratory mice and rats have shown that prenatal cocaine exposure increases adult self-administration of cocaine (59; 49; 103) and increases the reward potency of cocaine in adulthood (68; 74). Research in experimental animals suggests that maternal consumption of cocaine can increase the propensity for later cocaine abuse in the offspring, even if the cocaine exposure occurred before conception. In a study utilizing experimental rats, Fant and colleagues allowed female adult rats to self-administer cocaine for several months, followed by at least one month of abstinence from cocaine, before the dams became pregnant (41). This ensured that all cocaine and its metabolites were cleared from the dams prior to pregnancy. Despite the clearance of cocaine before pregnancy, the male progeny of these dams had an increased self-administration of cocaine during adulthood. Although the previous cocaine exposure increased cocaine reinforcing efficacy in the offspring, it did not impair learning or anxiety-like behaviors. These findings suggest that preconception cocaine consumption can selectively enhance cocaine consumption in offspring, even if it does not diminish other forms of learning or behavior. One possibility is that the preconception cocaine induces epigenetic changes in the oocytes, resulting in changes in the developmental trajectory (41).

Evidence suggests that this propensity for later abuse also occurs in humans. A prospective, longitudinal, cohort study showed that people exposed to cocaine prenatally or during early postnatal life are substantially more likely to use cocaine at 14 years of age (31). Because the study controlled extensively for child, parent, and community risk factors, the results suggest that it was the cocaine itself that increased the risk for future use. Additionally, published studies have found that prenatal cocaine exposure substantially increases the likelihood that an adolescent will use and abuse tobacco, alcohol, and marijuana (85; 87). One research study suggests that prenatal cocaine exposure leads to later substance abuse, at least in part, through increased risk-taking behavior (83). Thus, prenatal cocaine exposure not only damages the developing brain, but it also renders that brain more vulnerable to cocaine and other addictions later in life.

Prognosis and complications

The long-term effect of prenatal cocaine exposure is a subject of much debate. Undoubtedly, a large proportion of children who were prenatally exposed to cocaine have a poor neurodevelopmental outcome (32; 33; 109; 91). Many will have developmental delay, cognitive impairment, attention deficits, behavior disorders, or a combination thereof. Children who were prenatally exposed to cocaine are more likely to require special education and support services when they reach school age (65). They may also have disrupted growth (10; 29). The debate centers not on whether or not these children tend to do well, but on what the role of cocaine, per se, is in this guarded prognosis. Many children prenatally exposed to cocaine are raised in dysfunctional families and have mothers that are polydrug abusers. The outcome of many children prenatally exposed to cocaine may be related more to their poor environment than to the biological effects of the previous cocaine exposure (53).

Beyond neuropsychiatric complications, prenatal cocaine exposure is linked to renal disease, particularly hydronephrosis. Research has also shown an association with increased prevalence of intracranial embryonal tumors (128).

Clinical vignette

The patient was the 2020 g product of a 38-week gestation, born to an 18-year-old gravida 1 para 1 unmarried woman. The pregnancy was complicated by maternal substance abuse, including “crack” cocaine and occasional binge alcohol consumption during the first four months of the pregnancy. The patient’s mother also smoked one pack of cigarettes per day during the first five months of the pregnancy and one-half pack per day during the remainder of the pregnancy. Prenatal care was not sought until the sixth month of gestation, and at that time a chlamydia trachomatis infection of the genital tract was diagnosed and treated successfully with erythromycin. All other routine maternal testing, including a test for HIV infection, was negative or normal.

Ultrasound examination at six months’ gestation revealed intrauterine growth retardation and a small biparietal diameter. However, no dysmorphic features were noted by ultrasound, and the placenta appeared normal.

The mother stated that she abstained from cocaine use from the end of the 18th week until the 38th week of gestation, at that time she smoked crack cocaine daily for three consecutive days. Several hours after smoking the cocaine on the third day, the mother noted some partially clotted bleeding from the vagina. Ultrasound examination revealed a partially abrupted placenta. The fetal heart rate was adequate at 130 beats per minute but showed poor variability.

The mother was immediately transported to the operating room, and the infant was delivered by cesarean section. Apgar scores were 5 at 1 minute and 7 at 5 minutes of age. After receiving moderate tactile stimulation, the infant made good respiratory efforts and, aside from his small gestational-age size, he appeared well. He was admitted to the intermediate care nursery.

Ballard maturity rating suggested a gestational age of 38 weeks. However, he had symmetrical growth disturbance with body weight, body length, and head circumference all less than fifth percentile for gestational age.

The newborn remained stable in the nursery until 14 hours of age when he had focal motor seizures consisting of rhythmic jerking of the right arm and leg. The seizure was stopped with phenobarbital. A head CT scan revealed an extensive area of low attenuation in the left middle cerebral artery distribution, highly suggestive of an acute ischemic stroke.

Cocaine-induced cerebral infarction in newborn (CT)

Head CT scan of 1-day-old infant exposed to cocaine in utero. CT reveals a large area of low attenuation in the distribution of the left middle cerebral artery; signal characteristics are suggestive of acute ischemic stroke. The r...

Urine toxicology screens for both the infant and his mother were positive for cocaine metabolites. Further work-up for the ischemic stroke, including coagulation studies, chest x-ray, echocardiogram, complete blood count, electrolyte profile, and tests of liver and kidney function were normal. It was noted that the timing of the cerebral infarction, as well as the placental abruption, corresponded to the timing of the cocaine exposure during the days prior to delivery.

The infant’s seizures were initially well controlled with phenobarbital, and he was discharged from the hospital into foster care at seven days of age. At nine months of age, he was seen in the child neurology clinic because of recurrent focal seizures involving the right arm and leg that occurred several times per day despite increasing doses of phenobarbital. Developmentally, the child was progressing normally. He was able to sit unattended and was beginning to pull himself to a standing position. However, examination revealed a right hemiparesis and hyperreflexia. In addition, he was microcephalic, with a head circumference below the fifth percentile, despite weight and length at the 50th percentile. Head CT scan revealed an extensive area of encephalomalacia in the left hemisphere, corresponding to the previous stroke.

Cocaine-induced cerebral infarction indications in an infant (CT)

This 9-month-old infant has a right-side hemiparesis and hyperreflexia and is moderately microcephalic. The CT scan shows an extensive area of encephalomalacia in the left hemisphere in a distribution corresponding to the previous...

The infant’s medication was switched from phenobarbital to carbamazepine, which controlled the seizures better. When the child was re-evaluated at three years of age, his seizure disorder was well controlled on carbamazepine. However, he was delayed in the acquisition of social-interpersonal skills and in language, despite a normal hearing evaluation. At six years of age, the child was impulsive, hyperactive, and required special education.

Biological basis

Etiology and pathogenesis

	• Cocaine impairs brain development in the fetus through a variety of mechanisms.
	• Cocaine binds to monoaminergic receptors, which, in developing neurons, can lead to alterations in their physiology, structure, and circuitry.
	• Within the developing brain, cocaine can reduce neuronal numbers by reducing their proliferation and survival.
	• Cocaine induces some its neuroteratogenic effects via excitotoxicity.

Although cocaine remains an illegal drug, it is readily available on the street in all major cities and throughout the school systems. Cocaine is available in several forms, including pure cocaine, cocaine adulterated with a variety of substances, and crack cocaine. Cocaine is injected intravenously, smoked as crack, or inhaled as a powder (54). All routes of administration produce sufficient drug levels to adversely affect fetal well-being.

Several distinct mechanisms underlie cocaine’s damaging effects on the developing fetus. These mechanisms include disruption of developing neurotransmitter systems, alteration in the structure of neurons and their circuitry, and hypoxia-ischemia due to cocaine’s vasoconstrictive actions.

Many brain regions, including the cerebrum, diencephalon, and brainstem utilize monoamines as neurotransmitters or are the targets of monoaminergic neurons. Derangement of monoaminergic neurotransmission is cocaine’s principal mechanism of action in the adult brain. Monoamines appear early in brain development and have critical regulatory roles in the development of neuronal circuitry. Thus, disturbances in these neurotransmitter systems could have far-reaching negative effects.

In experimental systems, acute and long-term abnormalities have been detected in tissue dopamine levels, receptor-binding densities, receptor-binding affinities, and subcellular receptor location (108; 115; 101).

In addition to altering monoaminergic systems, prenatal cocaine also corrupts GABAergic systems. In the prenatal brain, cocaine reduces GABAergic inhibition and reduces the ratio of GABAergic-to-projection neurons in the cerebral cortex (79). These physiological changes impair the balance between excitatory and inhibitory neurotransmission, enhance epileptogenicity, and lead to long-term changes in synaptic plasticity (71).

The cerebral cortex is not the only site at which prenatal cocaine exposure alters the GABA system. In the striatum, prenatal cocaine pathologically enhances GABA interneuron function, which depresses corticostriatal activity. This leads to imbalances within the striatal microcircuitry, which has adverse effects on motor control, cognition, and learning (122).

Another important physiologic change that cocaine produces in the developing brain is a delay in the maturation of glutamatergic synaptic transmission (14). Cocaine produces this effect by inhibiting dopamine transporters on the dopaminergic neurons in the ventrotegmental area, which project to and enhance the maturation of glutamatergic neurons throughout the cortex. This finding demonstrates how a teratogenic agent that acts on the receptors of one neurotransmitter system in a localized brain region can disrupt the actions of multiple neurotransmitter systems throughout the brain.

Cocaine further alters glutamatergic synaptic transmission by changing glutamatergic synaptogenesis. A study has shown that cocaine induces spinogenesis and the generation of glutamatergic synapses through glial mechanisms. In particular, cocaine induces astrocytes to express thrombospondins, which, in turn, induce the formation of glutamatergic synapses. This study further showed that the formation of these synapses leads to altered behavioral patterns (121).

Prenatal cocaine alters not only the physiology of neurons, but their structure as well. Unlike alcohol and heroin, which diminish dendrite outgrowth, exposure of the developing neurons to cocaine can induce an exuberant overgrowth of cortical neuron dendrites. The dendritic trees of cortical neurons exposed to cocaine have greater branch length and branch number (48; 72). This dendritic overgrowth occurs selectively in cortical regions receiving strong dopaminergic innervation and is likely mediated by altered dopaminergic neurotransmission (116). Experimental animals are impaired in behaviors specifically mediated by cortical areas receiving strong dopaminergic innervation, indicating a correlation between excessive neurite outgrowth and abnormal behavior (105; 48).

In addition to altering the shape of neurons, prenatal cocaine exposure can also disrupt neuronal migration. During brain development, especially during the second trimester, newly formed neurons undergo a migration that takes them to their ultimate location in the developed functioning brain. Cortical neurons originate from the subventricular zone, adjacent to the lateral ventricles, and migrate radially and tangentially to their mature location in the cerebral cortex. Cocaine exposure in primates can cause neocortical cytoarchitectural abnormalities. However, these abnormalities in cortical architecture are observed only when the cocaine exposure occurs in the second trimester (67). These disruptions in cortical architecture are due to a disturbance in the radial and tangential migration of neocortical neurons (64). The findings that cocaine alters neuronal migration and disrupts cortical architecture only when the exposure occurs in the second trimester demonstrates that the pathophysiology and outcome of prenatal cocaine exposure in humans likely depends strongly on the gestational age of the fetus at the time of exposure.

Cocaine exposure also induces abnormal wiring of neural circuitry (21). This effect may be mediated by changes in the expression of axon guidance molecules, which play key roles in directing axons toward their target cells and in the establishment and stability of synapses. Cocaine substantially alters the expression of multiple families of axon guidance molecules, including the Semaphorins, Ephs, Ephrins, and neuropilins, within the mesolimbic dopamine system (09).

Prenatal cocaine decreases the number of neurons by decreasing both neuronal survival and proliferation. Cocaine induces apoptosis in brain regions by altering Bcl-2, Bax, and other apoptotic proteins and subsequently activating the caspase 3, caspase-8, and caspase-9 apoptotic signaling cascades (34; 133). Cocaine inhibits neuronal proliferation by arresting the cell cycle (51) at the G1-to-S transition (63). Reductions in neuronal number, both as a result of neuronal death and decreased proliferation, likely contribute to neurodevelopmental and cognitive deficits. In addition, the decreased neuronal number likely underlies the permanent brain growth deficits observed in volumetric MRI studies of children prenatally exposed to cocaine (102). In addition, the decreased neuronal number likely underlies the permanent brain growth deficits observed in volumetric MRI studies of newborns and of older children prenatally exposed to cocaine (102; 96).

Cocaine may also exert some of its neuroteratogenic effects via epigenetic mechanisms. Insulin-like growth factor II (Igf-II) is an imprinted gene that plays an important role in learning and memory. In a mouse model, prenatal cocaine exposure altered the methylation status of Igf-II and decreased expression of the gene in the hippocampus (136). These molecular changes were accompanied by impaired performance on the Morris water maze and open field tasks. Furthermore, the cognitive deficits were reversed through the hippocampal injection of recombinant Igf-II. Thus, epigenetic changes in gene expression may underlie some of the neurobehavioral deficits of prenatal cocaine exposure. The epigenetic sequelae of prenatal cocaine exposure remain an area of active research, including a link between prenatal exposure and decreased gestational age estimates (119).

Excitotoxicity also contributes to the neuronal injury of fetuses exposed to cocaine. Catecholamines, through their actions as glutamate agonists, can induce neuronal cell death (106). This is especially true in dopaminergic neurons and their projection targets. Further evidence that cocaine interacts with glutamatergic systems to induce excitotoxic effects lies in the observation that glutamate receptor antagonists can substantially reduce cocaine-induced convulsions and death in experimental animals (104).

In addition to binding catecholamine receptors, cocaine specifically interacts with other cellular proteins to exert its teratogenic effects. In particular, cocaine binds to sigma receptors, which are endoplasmic reticular proteins (118). Via this interaction, cocaine dissociates certain cytoskeletal adaptor proteins that are important for protein trafficking, membrane protein clustering, dendrite growth, and the morphological maintenance of neurons. In this way, cocaine may permanently change neuronal structure and physiology.

Fetal cocaine exposure may induce substantial destructive lesions of the developing brain. These destructive lesions are due to infarction, reflecting cocaine-induced vasospasm. Application of cocaine to pial arteries of neonatal piglets and fetal and neonatal lambs induces a constriction in vessel diameter and a decrease in cerebral blood flow (120).

Epidemiology

	• Since the 1970s, cocaine has been a widely abused drug across the world.
	• Cocaine is commonly abused by pregnant women in the United States and elsewhere.
	• Pregnant women who abuse cocaine are disproportionately older, African American, and of low socioeconomic status, but cocaine abuse is found in women of all demographics.

Prior to the 1970s, cocaine was not a frequently abused drug in the United States. Cocaine use in the United States spiked in the 1970s and 1980s, as it became a vogue component of the disco culture and the drug of choice within many inner cities. Cocaine use remained high through 2006, when it began to decline considerably. The decline in cocaine use in the United States reflected both a waning interest in the drug and effective antidrug strategies in Colombia, its major source. However, since 2012, cocaine use in the United States has been surging again. Both the number of users and the number of deaths from cocaine overdose increased steadily between 2012 and 2015 (52). In 2016, global use of cocaine increased by 7%, reflecting its use by 18.2 million people, or 0.4% of the world population aged 15 to 64. The use of cocaine is highest in North and South America, Western and Central Europe, and Oceania, especially Australia and New Zealand (131). Since 2011, cocaine use has gradually increased in the general United States population, and this same phenomenon has been seen among pregnant women (134).

In the United States, cocaine use underlies many acute medical problems. Forty percent of emergency department visits related to substance abuse are associated with cocaine, making cocaine the leading cause of emergency room visits due to illicit drug use (111).

Both cocaine and crack are widely used in American society, including by pregnant women. In 2015, cocaine was the second most commonly used illicit substance by pregnant women (behind marijuana). In that year, 3.4% of pregnant women had used cocaine in the past month. Pregnant women who use crack or cocaine tend to be older, African American, and of low socioeconomic status. Among pregnant women, cocaine use is the leading cause of antepartum hospitalizations for substance use (111).

Diagnostic workup

	• Because women are often not forthcoming with information regarding drug use during pregnancy, laboratory studies are often necessary to detect and confirm prenatal cocaine exposure.
	• Meconium and urine are the most commonly tested media for cocaine and its metabolites.
	• Other media or tissues, such as infant hair, amniotic fluid, and umbilical cord offer advantages for postnatal detection of prenatal drug exposure.

Women are often not forthcoming about their use of cocaine and other illicit drugs during pregnancy. For this reason, laboratory studies are often relied on to make the diagnosis of prenatal cocaine exposure. Like all laboratory tests, those for prenatal cocaine exposure are subject to laboratory errors. Most laboratory errors occur during the pre-analytic phase of testing, due to mistakes in sample collection. Laboratory errors have occurred in cases of suspected prenatal cocaine exposure, which has led to both medical and legal confusion and consequences. For this reason, institutions have been urged to establish stringent procedures when screening newborns for cocaine and other illicit drugs (98).

The diagnostic evaluation for intrauterine cocaine exposure includes a urine test and a meconium analysis for cocaine and its metabolites. The urine test is sensitive to recent cocaine exposure, but cocaine metabolites may be cleared from the urine within days. In contrast, meconium may remain positive for cocaine following exposure of a fetus weeks or months earlier in gestation. Thus, the use of meconium may capture a broader window of cocaine exposure (19).

Meconium is a viscous, semisolid tar-like substance and is not homogeneous. Thus, although meconium offers the advantage of a broad window of exposure assessment, the testing of meconium samples is often cumbersome and technically challenging. In response to these challenges, a new method for analyzing cocaine metabolites and other drugs of abuse in meconium has been introduced (46). This technique, which utilizes ceramic homogenizers prior to salt-assisted liquid-liquid extraction and liquid chromatography tandem mass spectrometry, may greatly expedite and improve the methodology of meconium testing.

In addition to infant urine and meconium, several other specimens can potentially identify infants prenatally exposed to cocaine. These include infant hair, maternal hair, amniotic fluid, umbilical blood, and the umbilical cord. The umbilical cord is emerging as a particularly attractive and useful tissue for testing because it is universally present in large quantities with each birth, is otherwise clinical waste, and can provide reliable results through the use of liquid chromatography/mass spectroscopy. Of course, maternal self-report of cocaine use can also identify prenatally exposed infants. However, the accuracy of self-reporting may be low because users tend to deny use due to guilt or fear of consequences (18; 75).

A study compared the sensitivity of a private, structured, nonthreatening interview regarding maternal drug-use history with laboratory testing of amniotic fluid, cord blood, infant urine, meconium, and maternal hair in identifying cocaine-exposed newborns (39). The study found that no single method could reliably identify all exposed infants. However, the method that maximally identified cocaine exposure was the maternal interview. Thus, maternal drug-use interviews that are thorough and nonthreatening may be the most reliable way of diagnosing prenatal cocaine exposure.

When an infant has a known exposure to cocaine, imaging of the CNS at birth is beneficial to determine if any CNS lesions have occurred. Neuroimaging is particularly indicated if microcephaly is present. Because of the association of cocaine exposure with renal disease, specifically hydronephrosis, an ultrasound of the kidney is recommended. The association with cardiac defects is small. Thus, clinical judgment should determine which children need cardiovascular evaluation.

Special considerations

Pregnancy

Because congenital cocaine syndrome is due to fetal cocaine exposure, the syndrome is inextricably linked to pregnancy. Many of the effects of cocaine on the fetus, such as later learning disabilities and disorders of language development, are not observed when people are postnatally exposed. Other adverse effects, such as strokes and hypertension, can occur from cocaine at any stage of life – whether pregnant or not.

Complications on the pregnant woman of cocaine use during pregnancy are many and include multiple organ systems. Among the most important are cardiovascular complications, including hypertension and myocardial infarction, hepatic rupture, renal failure, stroke and transient ischemic attack, and maternal death.

Pregnant women who abuse cocaine are at increased risk for multiple adverse perinatal outcomes, including preterm delivery, low birth weight, and small for gestational age infants. Maternal cocaine use also increases the risk of vertical transmission of hepatitis, syphilis, and HIV (111).

Anesthesia

Children prenatally exposed to cocaine do not react differently to anesthesia than do other children.

Acute cocaine intake can precipitate several obstetric emergencies, including placental abruption. Delivery of the fetus is usually the treatment of choice for placental abruption. However, acute cocaine intoxication greatly complicates the choice and use of anesthesia in these cases. This is due to the facts that pregnancy enhances the cardiovascular toxicity of cocaine and that cocaine can induce combative behavior, altered pain perception, thrombocytopenia, and hypertension. Both regional and general anesthesia in the cocaine-intoxicated parturient may be associated with serious complications for both the mother and baby (61).

References

01: Acker D, Sachs BP, Tracey KJ, Wise WE. Abruption placentae associated with cocaine use. Am J Obstet Gynecol 1983;146:220-1. PMID 6846442
02: Addis A, Moretti ME, Ahmed Syed F, Einarson TR, Koren G. Fetal effects of cocaine: an updated meta-analysis. Reprod Toxicol 2001;15(4):341-69. PMID 11489591
03: Alati R, Al Mamun A, Williams GM, O'Callaghan M, Najman JM, Bor W. In utero alcohol exposure and prediction of alcohol disorders in early adulthood: a birth cohort study. Arch Gen Psychiatry 2006;63(9):1009-16. PMID 16953003
04: Al Mamun A, O'Callaghan FV, Alati R, et al. Does maternal smoking during pregnancy predict the smoking patterns of young adult offspring. A birth cohort study. Tob Control 2006;15(6):452-7. PMID 17130374
05: Anonymous. Substance abuse in pregnancy. ACOG Technical Bulletin Number 195--July 1994 (replaces No. 96, September 1986). Int J Gynaecol Obstet 1994;47(1):73-80. PMID 7813759
06: Azuma SD, Chasnoff IJ. Outcome of children prenatally exposed to cocaine and other drugs: a path analysis of three-year data. Pediatrics 1993;92:396-401. PMID 7689727
07: Bada HS, Das A, Bauer CR, et al. Impact of prenatal cocaine exposure on child behavior problems through school age. Pediatrics 2007;119(2):e348-59. PMID 17272597
08: Baer JS, Sampson PD, Barr HM, Connor PD, Streissguth AP. A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinking. Arch Gen Psychiatry 2003;60(4):377-85. PMID 12695315
09: Bahi A, Dreyer JL. Cocaine-induced expression changes of axon guidance molecules in the adult rat brain. Mol Cell Neurosci 2005;28:275-91. PMID 15691709
10: Bandstra ES, Morrow CE, Anthony JC, et al. Intrauterine growth of full-term infants: impact of prenatal cocaine exposure. Pediatrics 2001;108(6):1309-19. PMID 11731653
11: Bandstra ES, Morrow CE, Vogel AL, et al. Longitudinal influence of prenatal cocaine exposure on child language functioning. Neurotoxicol Teratol 2002;24(3):297-308. PMID 12009485
12: Bateman DA, Chiriboga CA. Dose-response effect of cocaine on newborn head circumference. Pediatrics 2000;106(3):E33. PMID 10969117
13: Bauer CR, Langer JC, Shankaran S, et al. Acute neonatal effects of cocaine exposure during pregnancy. Arch Pediatr Adolesc Med 2005;159:824-34. PMID 16143741
14: Bellone C, Mameli M, Luscher C. In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA. Nature Neurosci 2011;14(11):1439-46. PMID 21964489
15: Bendersky M, Bennett D, Lewis M. Aggression at age five as a function of prenatal exposure to cocaine, gender and environmental risk. J Ped Psychol 2006;31:71-84. PMID 15827351
16: Bennett DS, Bendersky M, Lewis M. Children’s intellectual and emotional-behavioral adjustment at 4 years as a function of cocaine exposure, maternal characteristics, and environmental risk. Dev Psychol 2002;38(5):648-58. PMID 12220044
17: Benveniste H, Fowler JS, Rooney WD, et al. Cocaine is pharmacologically active in the nonhuman primate fetal brain. Proc Natl Acad Sci U S A 2010;107(4):1582-7. PMID 20080687
18: Carlier J, La Maida N, Di Trauna A, Huestis MA, Pichini S, Busardo F. Testing unconventional matrices to monitor for prenatal exposure to heroin, cocaine, amphetamines, synthetic cathinones, and synthetic opioids. Ther Drug Monit 2020;42(2):205-21. PMID 31809406
19: Cortes L, Almeida L, Sabra S, et al. Maternal hair and neonatal meconium to assess gestational consumption and prenatal exposure to drugs of abuse and psychoactive drugs. Curr Pharm Biotechnol 2018;19(2):136-43. PMID 29621962
20: Campillo F, Remezal M, Vez MD, et al. Symmetrical fetal growth retardation after gestational cocaine exposure in the rat. Europ J Obstet Gynecol Reprod Biol 2004;117:148-53. PMID 15541849
21: Chao J, Nestler EJ. Molecular neurobiology of drug addiction. Annu Rev Med 2004;55:113-32. PMID 14746512
22: Chasnoff IJ, Bussey ME, Savich R, Stack CM. Perinatal cerebral infarction and maternal cocaine use. J Pediatr 1986;108:456-9. PMID 3950828
23: Chasnoff IJ, Griffith DR, Freier C, Murray J. Cocaine/polydrug use in pregnancy: two-year follow-up. Pediatrics 1992;89:284-9. PMID 1370867
24: Chasnoff IJ, Hunt CE, Kletter R, Kaplan D. Prenatal cocaine exposure is associated with respiratory pattern abnormalities. Am J Dis Child 1989;143:583-7. PMID 2636852
25: Chiriboga CA, Bateman DA, Brust JC, Hauser WA. Neurologic findings in neonates with intrauterine cocaine exposure. Pediatr Neurol 1993;9:115-9. PMID 8499039
26: Church MW. Does cocaine cause birth defects. Neurotoxicol Teratol 1993;15:289. PMID 8277916
27: Coles CD. Saying “goodbye” to the “crack baby.” Neurotoxicol Teratol 1993;15:290-2. PMID 8277917
28: Cornelius MD, Leech SL, Goldschmidt L, Day NL. Is prenatal tobacco exposure a risk factor for early adolescent smoking. A follow-up study. Neurotoxicol Teratol 2005;27(4):667-76. PMID 16014324
29: Covington CY, Nordstrom-Klee B, Ager J, Sokol R, Delaney-Black V. Birth to age 7 growth of children prenatally exposed to drugs: a prospective cohort study. Neurotoxicol Teratol 2002;24(4):489-96. PMID 12127894
30: Cronin M, Ludtke M, Willwerth J. Crack kids. Time 1991:56.
31: Delaney-Black V, Chiodo LM, Hannigan JH, et al. Prenatal and postnatal cocaine exposure predict teen cocaine use. Neurotox Teratol 2011;33:110-9. PMID 20609384
32: Delaney-Black V, Covington C, Templin T, Ager J, Martier S, Sokol R. Prenatal cocaine exposure and child behavior. Pediatrics 1998;102(4 Pt 1):945-50. PMID 9755270
33: Delaney-Black V, Covington C, Templin T, et al. Expressive language development of children exposed to cocaine prenatally: literature review and report of a prospective cohort study. J Commun Disord 2000;33(6):463-80; quiz 480-1. PMID 11141028
34: Dey S, Mactutus CF, Booze RM, Snow DM. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Neuroscience 2007;144(2):509-21. PMID 17084983
35: Dombrowski MP, Wolfe HM, Welch RA, Evans MI. Cocaine abuse is associated with abruptio placentae and decreased birth weight, but not shorter labor. Obstet Gynecol 1991;77(1):139-41. PMID 1984213
36: Domenici C, Cultano A, Nardini V, Varese L, Ghirri P, Boldrini A. Drug addiction during pregnancy: correlations between the placental health and the newborn’s outcome – Elaboration of a predictive score. Gynecol Endocrinol 2009;25:786-92. PMID 19905997
37: Durand DJ, Espinoza AM, Nickerson BG. Associates between prenatal cocaine exposure and sudden infant death syndrome. J Pediatr 1990;117:909-11. PMID 2246690
38: Eyler FD, Behnke M, Conlon M, Woods NS, Wobie K. Birth outcome from a prospective, matched study of prenatal crack/cocaine use: II. Interactive and dose effects on neurobehavioral assessment. Pediatrics 1998;101:237-41. PMID 9445497
39: Eyler FD, Behnke M, Wobie K, Garvan CW, Tebbett I. Relative ability of biologic specimens and interviews to detect prenatal cocaine use. Neurotox Teratol 2005;27:677-87. PMID 15922559
40: Fang Y, Ronnekleiv OK. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. J Neurosci 1999;19(20):8966-78. PMID 10516315
41: Fant B, Wimmer ME, Swinford-Jackson SE, Maurer J, Van Nest D, Pierce RC. Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring. Psychopharmacology (Berl) 2019;236(12):3429-37. PMID 31236644
42: Farrar HC, Kearns GL. Cocaine: clinical pharmacology and toxicology. J Pediatr 1989;115:665-75. PMID 2681634
43: Frank DA, Augustyn M, Knight WG, Pell T, Zuckerman B. Growth, development, and behavior in early childhood following prenatal cocaine exposure: a systematic review. JAMA 2001;285(12):1613-25. PMID 11268270
44: Gad A, Morelli P, Decristofaro J. Perinatal isolated atrial flutter associated with maternal cocaine and opiate use in a late preterm infant. J Matern Fetal Neonatal Med 2010;23(9):1062-5. PMID 20025555
45: Garcia-Algar O, Felipe A, Puig C, Monleon T, Pacifici R, Pichini S. Fetal exposure to cocaine and infections during the first 18 months of life in infants from a Mediterranean city. Acta Paediatr 2007;96(5):762-3. PMID 17381476
46: Goggin MM, Janis GC. Salt-assisted liquid-liquid extraction of meconium for analysis of cocaine and amphetamines by liquid chromatography-tandem mass spectrometry. Methods Mol Biol 2019;1872:199-209. PMID 30350292
47: Gouin K, Murphy K, Shah PS; Knowledge Synthesis group on Determinants of Low Birth Weight and Preterm Births. Effects of cocaine use during pregnancy on low birthweight and preterm birth: systematic review and metaanalyses. Am J Obstet Gynecol 2011;204(4):340.e1-12. PMID 21257143
48: Harvey JA. Cocaine effects on the developing brain: current status. Neurosci Biobehav Rev 2004;27(8):751-64. PMID 15019425
49: Hecht GS, Spear NE, Spear LP. Alterations in the reinforcing efficacy of cocaine in adult rats following prenatal exposure to cocaine. Behav Neurosci 1998;112(2):410-8. PMID 9588487
50: Heffelfinger AK, Craft S, White DA, Shyken J. Visual attention in preschool children prenatally exposed to cocaine: implications for behavioral regulation. J Int Neuropsychol Soc 2002;8(1):12-21. PMID 11843069
51: Hu S, Cheeran MC, Sheng WS, Ni HT, Lokensgard JR, Peterson PK. Cocaine alters proliferation, migration, and differentiation of human fetal brain-derived neural precursor cells. J Pharmacol Exp Ther 2006;318(3):1280-6. PMID 16766721
52: Hughes A, Williams MR, Lipari RN, Van Horn S. State estimates of past year cocaine use among young adults: 2014 and 2015. CBHSQ Report 2016. PMID 28252899
53: Hurt H, Malmud E, Betancourt LM, Brodsky NL, Giannetta JM. A prospective comparison of developmental outcome of children with in utero cocaine exposure and controls using the Battelle Developmental Inventory. J Dev Behav Pediatr 2001;22(1):27-34. PMID 11265920
54: Jeffcoat AR, Perez-Reyes M, Hill JM, Sadler BM, Cook CE. Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking. Am Soc Pharmacol Exp Therapeut 1989;17:153-9. PMID 25411733
55: John V, Dai H, Talati A, Charnigo RJ, Neuman M, Bada HS. Autonomic alterations in cocaine-exposed neonates following orthostatic stress. Pediatr Res 2007;61(2):251-6. PMID 17237731
56: Johns J, Means L, Bass E, Means M, McMillen B. Prenatal exposure to cocaine: Effects on aggression in Spreague-Dawley rats. Dev Psychobiol 1994;27:227-39. PMID 7913451
57: Johns J, Noonan L. Prenatal cocaine exposure affects social behavior in Sprague-Dawley rats. Neurotoxicol Teratol 1995;17:569-76. PMID 8552003
58: Kandel DB, Wu P, Davies M. Maternal smoking during pregnancy and smoking by adolescent daughters. Am J Public Health 1994;84(9):1407-13. PMID 8092363
59: Keller RW Jr, LeFevre R, Raucci J, Carlson JN, Glick SD. Enhanced cocaine self-administration in adult rats prenatally exposed to cocaine. Neurosci Lett 1996;205(3):153-6. PMID 8852581
60: Konkol RJ, Murphey LJ, Ferriero DM, Dempsey DA, Olsen GD. Cocaine metabolites in the neonate: potential for toxicity. J Child Neurol 1994;9:242-8. PMID 7930402
61: Kuczkowski KM. Caesarean section in a cocaine-intoxicated parturient: regional vs. general anaesthesia. Anaesthesia 2003;58(10):1042-103. PMID 12969070
62: Landi N, Avery T, Crowley MJ, Wu J, Mayes L. Prenatal cocaine exposure impacts language and reading into late adolescence: behavioral and ERP evidence. Development Neuropsychol 2017;42(6):369-86. PMID 28949778
63: Lee CT, Chen J, Hayashi T, et al. A mechanism for the inhibition of neural progenitor cell proliferation by cocaine. PLoS Med 2008;5(6):e117. PMID 18593214
64: Lee CT, Chen J, Worden LT, Freed WJ. Cocaine causes deficits in radial migration and alters the distribution of glutamate and GABA neurons in the developing rat cerebral cortex. Synapse 2011;65:21-34. PMID 20506319
65: Levine TP, Liu J, Das A, et al. Effects of prenatal cocaine exposure on special education in school-aged children. Pediatrics 2008;122(1):e83-91. PMID 18541617
66: Lewis BA, Kirchner HL, Short EJ, et al. Prenatal cocaine and tobacco effects on children's language trajectories. Pediatrics 2007;120(1):e78-85. PMID 17606552
67: Lidow MS, Bozian D, Song ZM. Cocaine affects cerebral neocortical cytoarchitecture in primates only if administered during neocortical neuronogenesis. Dev Brain Res 2001;128:45-52. PMID 11356261
68: Lin D, Kellogg CK. Neonatal exposure to cocaine enhances the reward-potentiating properties of the drug in young adult animals. Behav Neurosci 1996;110(4):791-801. PMID 8864269
69: Little BB, Snell LM. Brain growth among fetuses exposed to cocaine in utero: asymmetrical growth retardation. Obstet Gynecol 1991;77(3):361-4. PMID 1992399
70: Liu J, Lester BM, Neyzi N, et al. Regional brain morphometry and impulsivity in adolescents following prenatal exposure to cocaine and tobacco. JAMA Pediatr 2013;167(4):348-54. PMID 23400239
71: Lu H, Lim B, Poo MM. Cocaine exposure in utero alters synaptic plasticity in the medial prefronatal cortex of postnatal rats. J Neurosci 2009;29(40):12664-74. PMID 19812341
72: Lu R, Liu X, Long H, Ma L. Effects of prenatal cocaine and heroin exposure on neuronal dendrite morphogenesis and spatial recognition memory in mice. Neurosci Lett 2012;522(2):128-33. PMID 22732446
73: Lutiger B, Graham K, Einarson TR, Koren G. Relationship between gestational cocaine use and pregnancy outcome: a meta-analysis. Teratology 1991;44:405-14. PMID 1835806
74: Malanga CJ, Riday TT, Carlezon WA Jr, Kosofsky BE. Prenatal exposure to cocaine increases the rewarding potency of cocaine and selective Dopaminergic agonists in adult mice. Biol Psychiatry 2008;63(2):214-21. PMID 17568568
75: Mamillapalli SS, Smith-Joyner A, Forbes L, et al. Screening for opioid and stimulant exposure in utero through targeted and untargeted metabolomics analysis of umbilical cords. Ther Drug Monit 2020;42(5):787-94. PMID 32142018
76: Mayes L, Snyder PJ, Langlois E, Hunter N. Visuospatial working memory in school-aged children exposed in utero to cocaine. Child Neuropsychol 2007;13(3):205-18. PMID 17453830
77: Mayes LC. Developing brain and in utero cocaine exposure: effects on neural ontogeny. Dev Psychopathol 1999;11:685-714. PMID 10624721
78: Mayes LC, Granger RH, Bornstein MH, Zuckerman B. The problem of prenatal cocaine exposure: a rush to judgment. JAMA 1992;267:406-8. PMID 1727966
79: McCarthy DM, Bhide PG. Prenatal cocaine exposure decreases parvalbumin-immunoreactive neurons and GABA-to-projection neuron ratio in the medial prefrontal cortex. Dev Neurosci 2012;34(2-3):174-83. PMID 22572769
80: McCormick MC. The contribution of low birth weight to infant mortality and childhood morbidity. N Eng J Med 1985;312:82-90. PMID 3880598
81: Mehta SK, Super DM, Connuck D, et al. Autonomic alterations in cocaine-exposed infants. Am Heart J 2002;144(6):1109-15. PMID 12486438
82: Mehta SK, Super DM, Salvator A, et al. Heart rate variability in cocaine-exposed newborn infants. Am Heart J 2001;142(5):828-32. PMID 11685170
83: Min MO, Minnes S, Kim SK, et al. Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21. Drug Alcohol Depend 2023;242:109736. PMID 36516550
84: Min MO, Minnes S, Lang A, Albert JM, Kim JY, Singer LT. Pathways to adolescent sexual risk behaviors: effects of prenatal cocaine exposure. Drug Alcohol Depend 2016;161:281-91. PMID 26922281
85: Min MO, Minnes S, Lang A, et al. Externalizing behavior and substance use related problems at 15 years in prenatally cocaine exposed adolescents. J Adolesc 2014;37(3):269-29. PMID 24636687
86: Minnes S, Min MO, Kim J, et al. The association of prenatal cocaine exposure, externalizing behavior and adolescent substance use. Drug Alcohol Depend 2017;176:33-43. PMID 28514694
87: Minnes S, Singer L, Min MO, Wu M, Lang A, Yoon S. Effects of prenatal cocaine/polydrug exposure on substance use by age 15. Drug Alcohol Depend 2014;134:201-10. PMID 24176200
88: Moore TR, Sorg J, Miller L, Key TC, Resnik R. Hemodynamics effects of intravenous cocaine on the pregnant ewe and fetus. Am J Obstet Gynecol 1986;155(4):883-8. PMID 3766645
89: Morie KP, Wu J, Landi N, Potenza MN, Mayes LC, Crowley MJ. Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation. Dev Neuropsychol 2018;43(3):183-97. PMID 29461102
90: Morie KP, Zhai ZW, Crowley MJ, Potenza MN, Mayes LC. Relationships between prenatal cocaine exposure, cannabis-use oonset and emotional and related characteristics in young/emerging adults. Subst Use Misuse 2024;59(3):388-97. PMID 37964628
91: Morrow CE, Bandstra ES, Anthony JC, Ofir AY, Xue L, Reyes MB. Influence of prenatal cocaine exposure on early language development: longitudinal findings from four months to three years of age. J Dev Behav Pediatr 2003; 24(1):39-50. PMID 12584484
92: Morrow CE, Culbertson JL, Accornero VH, Xue L, Anthony JC, Bandstra ES. Learning disabilities and intellectual functioning in school-aged children with prenatal cocaine exposure. Dev Neuropsychol 2006;30(3):905-31. PMID 17083299
93: Nelson J, Marshall MF. Ethical and legal analyses of three coercive policies aimed at substance abuse by pregnant women. Charleston, SC: The Robert Wood Johnson Foundation, 1998.
94: Newport DJ, Hostetter AL, Juul SH, et al. Prenatal psychostimulant and antidepressant exposure and risk of hypertensive disorders of pregnancy. J Clin Psychiatry 2016;77(11):1538-45. PMID 28076672
95: Paltrow LM. Pregnant drug users, fetal persons, and the threat to Roe v Wade. Albany Law Rev 1999;62:999-1055.
96: Peterson BS, Rosen T, Dingman S, et al. Associations of maternal prenatal drug abuse with measures of newborn brain structure, tissue organization, and metabolite concentrations. JAMA Peds 2020;174(9):831-42. PMID 32539126
97: Powers G, Lewis B, Min MO, et al. The association of prenatal cocaine exposure with expressive and receptive language skills, phonological processing and reading ability at age 17. Neurotoxicol Teratol 2023;95:107135. PMID 36395974
98: Puthenpura V, Gueye-Ndiaye S, Joshi S, Puvabanditsin S, Carayannopoulos MO. Social and legal implications of urine drug screen analysis in the neonate: A case of suspected specimen mishandling. Clinica Chimica Acta 2020;511:104-6. PMID 33002470
99: Richardson GA, De Genna NM, Goldschmidt L, Larkby C, Donovan JE. Prenatal cocaine exposure: direct and indirect associations with 21-year-old offspring substance use and behavior problems. Drug Alcohol Depend 2019;195:121-31. PMID 30622013
100: Richardson GA, De Genna NM, Willford JA, Goldschmidt L. Pathways from prenatal cocaine exposure to adult substance use and behavior. Neurotoxicol Teratol 2024;102:107335. PMID 38373556
101: Riley E, Maymi v, Pawlyszyn S, Yu L, Zhdanova IV. Prenatal cocaine exposure disrupts the dopaminergic system and its postnatal responses to cocaine. Genes Brain Behav 2018;17(4):e12436. PMID 29105298
102: Rivkin MJ, Davis PE, Lemaster JL, et al. Volumetric MRI study of brain in children with intrauterine exposure to cocaine, alcohol, tobacco, and marijuana. Pediatrics 2008;121:741-50. PMID 18381539
103: Rocha BA, Mead AN, Kosofsky BE. Increased vulnerability to self-administer cocaine in mice prenatally exposed to cocaine. Psychopharmacology (Berl) 2002;163(2):221-9. PMID 12202969
104: Rockhold RW, Oden G, Ho IK, Andrew M, Farley JM. Glutamate receptor antagonists block cocaine-induced convulsions and death. Brain Res Bull 1991;27(5):721-3. PMID 1684527
105: Romano AG, Harvey JA. Prenatal exposure to cocaine disrupts discrimination learning in adult rabbits. Pharmacol Biochem Behav 1996;53(3):617-21. PMID 8866963
106: Rosenberg PA. Catecholamine toxicity in cerebral cortex in dissociated cell culture. J Neurosci 1988;8(8):2887-94. PMID 2900882
107: Schuetze P, Eiden RD, Coles CD. Prenatal cocaine and other substance exposure: effects on infant autonomic regulation at 7 months of age. Dev Psychobiol 2007;49(3):276-89. PMID 17380506
108: Silvers JM, Wallace DR, Harrod SB, Mactutus CF, Booze RM. Prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and adolescent offspring. Neurotoxicol Teratol 2006;28(2):173-80. PMID 16529908
109: Singer LT, Arendt R, Minnes S, Farkas K, Salvator A. Neurobehavioral outcomes of cocaine-exposed infants. Neurotoxicol Teratol 2002;22(5):653-66. PMID 11106858
110: Singer LT, Yamashita TS, Hawkins S, Cairns D, Baley J, Kliegman R. Increased incidence of intraventricular hemorrhage and developmental delay in cocaine-exposed, very low birth weight infants. J Pediatr 1994;124(5 Pt 1):765-71. PMID 7513757
111: Smid MC, Metz TD, Gordon AJ. Stimulant use in pregnancy – an under-recognized epidemic among pregnant women. Clin Obstet Gynecol 2019;62(1):168-84. PMID 30601144
112: Smith LM, Qureshi N, Renslo R, Sinow RM. Prenatal cocaine exposure and cranial sonographic findings in preterm infants. J Clin Ultrasound 2001;29(2):72-7. PMID 11425091
113: Spires MC, Gordon EF, Choudhuri M, Maldonado E, Chan R. Intracranial hemorrhage in a neonate following prenatal cocaine exposure. Pediatric Neurol 1989;5:324-6. PMID 2679587
114: Sprauve ME, Lindsay MK, Herbert S, Graves W. Adverse perinatal outcome in parturients who use crack cocaine. Obstet Gynecol 1997;89(5 Pt 1):674-8. PMID 9166299
115: Stanwood GD, Levitt P. Prenatal exposure to cocaine produces unique developmental and long-term adaptive changes in dopamine D1 receptor activity and subcellular distribution. J Neurosci 2007;27(1):152-7. PMID 17202482
116: Stanwood GD, Washington RA, Shumsky JS, Levitt P. Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of cerebral cortex. Neuroscience 2001;106(1):5-14. PMID 11564412
117: Streissguth AP, Grant TM, Barr HM, et al. Cocaine and the use of alcohol and other drugs during pregnancy. Am J Obstet Gynecol 1991;164:1239-43. PMID 2035565
118: Su TP, Hayashi T. Cocaine affects the dynamics of cytoskeletal proteins via sigma(1) receptors. Trends Pharmacol Sci 2001;22(9):456-8. PMID 11543872
119: Viola TW, Danzer C, Mardini V, et al. Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans. Sci Rep 2024;14(1):1946. PMID 38253635
120: Volpe JJ. Effect of cocaine use on the fetus. N Engl J Med 1992;327:399-407. PMID 1625714
121: Wang J, Li KL, Shukla A, et al. Cocaine triggers astrocyte-mediated synaptogenesisBiol Psych 2021;89:386-97. PMID 33069367
122: Wang W, Nitulescu I, Lewis JS, et al. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Ann Neurol 2013;73(3):355-69. PMID 23225132
123: Ward SL, Bautista D, Chan L, et al. Sudden infant death syndrome in infants of substance-abusing mothers. J Pediatr 1990;117:876-81. PMID 2246684
124: Ward SL, Schuetz S, Krishna V, et al. Abnormal sleeping ventilatory pattern in infants of substance-abusing mothers. Am J Dis Child 1986;140:1015-20. PMID 3752011
125: Wasiewski WW, Hansen T, Hazinski T. Intrauterine hypoxemia and control of ventilation. Pediatr Pulmonol 1988;5:264.
126: Will GF. Paying addicts not to have kids is a good thing. Baltimore Sun. November 1, 1999:15A.
127: Williams SK, Johns JM. Prenatal and gestational cocaine exposure: effects on the oxytocin system and social behavior with implications for addiction. Pharm Biochem Behav 2014;119:10-21. PMID 23880214
128: Wimberly CE, Gulrajani NB, Russ JB, et al. Maternal prenatal use of alcohol, tobacco, and illicit drugs and associations with childhood cancer subtypes. Cancer Epidemiol Biomarkers Prev 2024;33(3):347-54. PMID 38112788
129: Wood R, Spear LP. Prenatal cocaine alters social competition of infant, adolescent and adult rats. Behav Neurosci 1998;112:419-31. PMID 9588488
130: Woods JR, Plessinger MA, Clark KE. Effect of cocaine on uterine blood flow and fetal oxygenation. JAMA 1987;257:957-61. PMID 3806879
131: Wouldes TA, Lester BM. Stimulants: how big is the problem and what are the effects of prenatal exposure? Semin Fetal Neonat Med 2019;24(2):155-60. PMID 30803902
132: Xiao D, Yang S, Zhang L. Prenatal cocaine exposure causes sex-dependent impairment in the myogenic reactivity of coronary arteries in adult offspring. Hypertension 2009;54:1123-8. PMID 19704103
133: Xiao D, Zhang L. Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain. Int J Med Sci 2008;5:295-302. PMID 18974856
134: Young-Wolff KC, Slama NE, Sarovar V, et al. Trends in self-reported and biochemically verified cocaine and methamphetamine use among pregnant individuals in northern California, 2011-2019. JAMA Network Open 2022;5(12):e2248055. PMID 36542384
135: Zhang H, Darwanto A, Linkhart TA, Sowers LC, Zhang L. Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart. Mol Pharmacol 2007;71(5):1319-28. PMID 17202284
136: Zhao Q, Hou J, Chen B, et al. Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. Neurobiol Dis 2015;82:54-65. PMID 26054440

Contributors

All contributors' financial relationships have been reviewed and mitigated to ensure that this and every other article is free from commercial bias.

Authors

Daniel J Bonthius MD PhD

Dr. Bonthius of Atrium Health/Levine Children's Hospital has no relevant financial relationships to disclose.
See Profile
Kaleb Mikami MD

Dr. Mikami of Levine Children's Hospital has no relevant financial relationships to disclose.
See Profile

Editor

Ann Tilton MD

Dr. Tilton has received honorariums from Allergan and Ipsen as an educator, advisor, and consultant.
See Profile

Former Authors

Warren Wasiewski MD
Michael V Johnston MD†
Bahri Karacay PhD
Nancy E Bonthius PharmD
Hannah Klein de Licona BS
Dylan Todd MD
Brittany Dillon ARNP
Natalie T Bonthius
Daniel Bonthius Jr BS

Patient Profile

Age range of presentation: 0 to 1 month
Sex preponderance: male=female
Heredity: none
Population groups selectively affected: none selectively affected
Occupation groups selectively affected: none selectively affected

ICD & OMIM codes

ICD-10: Mental and behavioural disorders due to use of cocaine: F14
ICD-11: Disorders due to use of cocaine: 6C45

Other specified toxic or drug-related embryofetopathies: LD2F.0Y

This is an article preview.
Start a Free Account
to access the full version.

Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Listen to MedLink on the go with Audio versions of each article.

Questions or Comment?

MedLink®, LLC

3525 Del Mar Heights Rd, Ste 304
San Diego, CA 92130-2122

Toll Free (U.S. + Canada): 800-452-2400

US Number: +1-619-640-4660

Support: service@medlink.com

Editor: editor@medlink.com

ISSN: 2831-9125

Congenital cocaine syndrome

Associated Disorders

Cocaine withdrawal syndrome
Renal disease
Sudden infant death syndrome

Differential Diagnosis

coagulation disturbances
antithrombin III deficiency
congenital deficiency of protein C or protein S
polycythemia with secondary sludging of blood in cerebral arteries or veins
bacterial meningitis with secondary vasculitis
- emboli
- emboli from degenerating placental vessels
- emboli recently activated pulmonary vascular bed
- fetal alcohol syndrome
- congenital infection with toxoplasmosis
- congenital infection with rubella
- congenital infection with cytomegalovirus
- congenital infection with HIV
- congenital infection with lymphocytic choriomeningitis virus
- chromosomal abnormalities
- hypoglycemia
- withdrawal from alcohol or opiates
- hypocalcemia
- hypoxic-ischemic encephalopathy

Also Relevant

Drug-induced seizures
Microcephaly
Neonatal opioid withdrawal syndrome
Stroke associated with drug abuse
Sudden infant death syndrome

Clinical Categories

General Child Neurology

Patient Handouts

Intrauterine growth retardation

Web References

Clinical Trials

NIH: Congenital Cytomegalovirus

Congenital cocaine syndrome …

Congenital cocaine syndrome

Introduction

Overview

Key points

Historical note and terminology

Clinical manifestations

Presentation and course

Prognosis and complications

Clinical vignette

Biological basis

Etiology and pathogenesis

Epidemiology

Prevention

Differential diagnosis

Diagnostic workup

Management

Special considerations

Pregnancy

Anesthesia

Media

References

Contributors

Authors

Editor

Former Authors

Patient Profile

ICD & OMIM codes

This is an article preview.
Start a Free Account
to access the full version.

Questions or Comment?

Also in This Category

NF2-related schwannomatosis

Breath-holding spells

Acute cerebellar ataxia in children

Headache in children: overview and treatment approaches

Alternating hemiplegia of childhood

Pyridoxine/P5P-dependent developmental epileptic encephalopathy

Zika virus: neurologic complications

Cerebral edema in childhood

	• Prevention of cocaine use is the key to avoiding cocaine-induced neurodevelopmental problems in babies and children.
	• The highly addictive properties of cocaine make stoppage of cocaine use very difficult.

	• In the neonatal period, much of the management of cocaine-exposed babies may focus on minimizing withdrawal symptoms.
	• During childhood, much of the management will focus on the long-term neurodevelopmental consequences, including attention deficits, behavior problems, and learning disorders.

Congenital cocaine syndrome

Introduction

Overview

Key points

Historical note and terminology

Clinical manifestations

Presentation and course

Prognosis and complications

Clinical vignette

Biological basis

Etiology and pathogenesis

Epidemiology

Prevention

Differential diagnosis

Diagnostic workup

Management

Special considerations

Pregnancy

Anesthesia

Media

References

Contributors

Authors

Editor

Former Authors

Patient Profile

ICD & OMIM codes

This is an article preview. Start a Free Account to access the full version.

Questions or Comment?

Also in This Category

NF2-related schwannomatosis

Breath-holding spells

Acute cerebellar ataxia in children

Headache in children: overview and treatment approaches

Alternating hemiplegia of childhood

Pyridoxine/P5P-dependent developmental epileptic encephalopathy

Zika virus: neurologic complications

Cerebral edema in childhood

This is an article preview.
Start a Free Account
to access the full version.