Wilson disease
Oct. 23, 2024
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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It is increasingly clear that a multitude of pathologies (in a population, and within an individual) can underlie the dementia clinical syndrome. Among the most common and impactful of these is limbic-predominant age-related TDP-43 encephalopathy (LATE), a very common “Alzheimer disease mimic” (16). Thus, the symptoms of LATE are similar to those of Alzheimer disease, and the pathology underlying LATE (TDP-43 proteinopathy) commonly, but not inevitably, co-occurs with Alzheimer disease. LATE affects approximately one quarter of individuals over 80 years of age.
• Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a common condition of aging (affects approximately one quarter of individuals over 80 years old). | |
• LATE neuropathologic change (LATE-NC) is the pathologic substrate. | |
• LATE-NC is characterized by TDP-43 pathology, mostly in the medial temporal lobes. | |
• LATE-NC is often comorbid with Alzheimer disease neuropathologic changes (ADNC, ie, amyloid plaques and neurofibrillary tangles). | |
• The prevalence of pathologies in persons over the age of 80 are as follows: ADNC+LATE-NC > pure ADNC > pure LATE-NC. | |
• The severity of the cognitive impairment is as follows: ADNC+LATE-NC > pure ADNC > pure LATE-NC. |
TDP-43 proteinopathy is a disease-associated pathological phenomenon discovered by Dr. Manuela Neumann and colleagues at UPENN, in the Drs. John Trojanowski/Virginia Lee CNDR Lab in 2006, in the context of neurologic diseases along a spectrum of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (21). TDP-43 pathology is also associated with over 20 other neurologic diseases (04), with TDPopathies being analogous to tauopathies. This has produced some confusion in the field.
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MedLink®, LLC
3525 Del Mar Heights Rd, Ste 304
San Diego, CA 92130-2122
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125