Jirair Bedoyan MD PhD FACMG

Associate Professor of Pediatrics
Division of Genetic and Genomic Medicine
University of Pittsburgh School of Medicine

Program Director, Clinical Biochemical Genetics Fellowship Program
UPMC Children’s Hospital of Pittsburgh

Director, Medical Genetics Clinical Research
Division of Genetic and Genomic Medicine
UPMC Children’s Hospital of Pittsburgh

University of Pittsburgh IRB Committee member

United Mitochondrial Disease Foundation (UMDF) Scientific and Medical Advisory Board (SMAB)

Bedoyan received his undergraduate degree in xhemistry with a minor in physics from Washington State University, Pullman, WA, in 1987 and earned a MSc in Microbiology in 1989. He then received a PhD in cellular and molecular biology from the University of Michigan, Ann Arbor, MI in 1996. Following graduation, Bedoyan worked as a postdoctoral fellow in the Basic Sciences Division at the Fred Hutchinson Cancer Research Center, Seattle, WA, and subsequently at the John D. Dingle Veteran Affairs Medical Center in Detroit, MI. Bedoyan received his Doctor of Medicine degree at Wayne State University School of Medicine in Detroit, MI, in 2004, and in 2007 completed a residency in Pediatrics at the UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, and subsequently a residency in Medical Genetics at the University of Michigan, Ann Arbor, MI in 2010. He completed his fellowship in Clinical Biochemical Genetics at Case Western Reserve University in 2014 and served as co-Medical Director (2014-17) and subsequently Medical Director (2018-21) at the Center for Inherited Disorders of Energy Metabolism (CIDEM) at the University Hospitals Cleveland Medical Center (UHCMC), Cleveland, OH. He also served as the Program Director of the Medical Biochemical Genetics Fellowship Program at UHCMC.

Bedoyan is a biochemical geneticist interested in investigating the genetics and pathophysiology of several inborn errors of metabolism and mitochondrial disorders, including disorders of pyruvate metabolism, particularly mitochondrial pyruvate dehydrogenase complex deficiency (PDCD) and pyruvate carboxylase deficiency (PCD). He has published over 50 articles, reviews, and book chapters. He has an active clinical research program with several government-funded and industry-sponsored clinical studies/trials. Bedoyan served as project co-PI (2014-19) and is currently PI (2019-24) on NIH-funded U54 Rare Disease Clinical Research Network (RDCRN), North American Mitochondrial Disease Consortium (NAMDC) project grants with a focus on mitochondrial PDCD and received pilot grants for clinical research from the Urea Cycle Disorders Consortium (UCDC) and NAMDC. Bedoyan has achieved local and national recognition for excellence in patient care and for his novel scholarly work to improve patient care and health outcomes for several complex inherited disorders of energy metabolism including PDCD and PCD.

Bedoyan serves as a member of the University of Pittsburgh IRB Committee and the United Mitochondrial Disease Foundation (UMDF) Scientific and Medical Advisory Board (SMAB). Bedoyan also serves as Communicating Editor on the Journal of Inherited Metabolic Disease (JIMD) and JIMD Reports and is on the Editorial Board for Metabolites.