Leigh syndrome
Sep. 04, 2023
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Progressive supranuclear palsy with vertical gaze palsy
This 64-year-old woman has a 7-year history of emotional incontinence, hypophonia, and progressive loss of balance, which resulted in a fall and a fracture of the right arm. Examination shows vertical ophthalmoplegia, which can be overcome by the oculocephalic maneuver, as well as apraxia of eye opening and broad-based unsteady gait. These findings are typical of progressive supranuclear palsy. (Contributed by Dr. Joseph Jankovic.)