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Progressive supranuclear palsy: saccades and pursuit

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This 65-year-old woman had 2 years of symptoms, starting with falls, then micrographia and hypophonia. The video begins with lid retraction and square-wave jerks in primary gaze, then shows intact horizontal saccades, poor vertical saccades, limited vertical pursuit of a moving target and then full horizontal pursuit. (Courtesy of www.neuroophthalmology.ca. Contributed by Dr. Jason Barton.)