Neuro-Ophthalmology & Neuro-Otology
Giant cell arteritis
Sep. 25, 2024
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Regulating and targeting liquid phase separation
Three modes of action currently link phase separation to pathology with the potential to serve as pathways for intervention. (A) The phase boundary, a metric for the propensity to phase-separate, is defined by the saturation concentration and the relative interaction strengths between molecules. (B) Material properties of condensed phases include viscoelasticity, reversibility of exchange, and the dynamics and mobility of molecules within and across droplets. (C) Fiber formation may be nucleated within droplets, potentially giving rise to pathology. These three modes of action, which are sensitive to disease-associated conditions, highlight distinct avenues for regulation and therapeutic targeting of liquid phase separation in disease. (Reproduced with author permission from: Elbaum-Garfinkle, S. Matter over mind: Liquid phase separation and neurodegeneration. J Biol Chem 2019;294(18):7160-68.)
Related
Article
Related
Media
Associated
Disorders
- Alzheimer disease
- Creutzfeldt-Jakob disease
- Familial amyotrophic lateral sclerosis
- Frontotemporal dementia
- Frontotemporal lobar degeneration
- Pick disease