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Autoimmune GFAP astrocytopathy patient imaging

(A) Brain MRI with FLAIR sequences revealing hyperintense lesions in the periventricular white matter of both hemispheres, with postgadolinium radial enhancement in T1 sequences (B). (C) Thoracic spine MRI with sagittal T2 images showing diffuse hyperintensities with patchy enhancement postgadolinium injection (D). (E) Follow-up imaging shows diffuse atrophy of the thoracic spinal cord. (Contributed by Dr. Andrew McKeon.)

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Associated Disorders

  • Conditions associated with T cell dysfunction (lymphopenia of unknown origin, HIV, exposure to immune checkpoint inhibitor treatment)
  • Neoplasms
  • Other organ or nonorgan specific autoimmune disorders
  • Overlapping nervous-system targeting autoimmunity