This is an image preview.
Start a Free Account
to view the full image.

Sign Up for a Free Account For information on discounts, see Plans & Pricing

Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Listen to MedLink on the go with Audio versions of each article.

Key mechanisms regarding the absorption, storage, and intracellular metabolism of vitamin B12 in human beings

Download

Abbreviations: Ado-VitB12, adenosylcobalamin, also more fully 5′-deoxyadenosylcobalamin; Cubam R, cubam receptor, a multi-ligand receptor located in the terminal ileum, specializing in absorption of vitamin B12; FA, folic acid; HC, haptocorrin (probably more commonly known as R-protein or transcobalamin I); HCy, homocysteine; IF, intrinsic factor; M-CoA, methylmalonyl-CoA; MRP1, multidrug-resistant protein 1; MTR, methionine synthase; MUT, L-methylmalonyl-CoA mutase; TC, transcobalamin; VitB12, vitamin B12.

(Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)