Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

Sign Up for a Free Account For information on discounts, see Plans & Pricing

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Key mechanisms regarding the absorption, storage, and intracellular metabolism of vitamin B12 in human beings

Abbreviations: Ado-VitB12, adenosylcobalamin, also more fully 5′-deoxyadenosylcobalamin; Cubam R, cubam receptor, a multi-ligand receptor located in the terminal ileum, specializing in absorption of vitamin B12; FA, folic acid; HC, haptocorrin (probably more commonly known as R-protein or transcobalamin I); HCy, homocysteine; IF, intrinsic factor; M-CoA, methylmalonyl-CoA; MRP1, multidrug-resistant protein 1; MTR, methionine synthase; MUT, L-methylmalonyl-CoA mutase; TC, transcobalamin; VitB12, vitamin B12.

(Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

Related Article

Related Media

Associated Disorders

  • Alcohol-tobacco amblyopia
  • Cerebral vascular disease
  • Dementia
  • Depression
  • Developmental delay
  • Folate deficiency
  • Gastric resection
  • Glossitis
  • Imerslund-Grasbeck syndrome
  • Malabsorption
  • Megaloblastic anemia
  • Myelopathy
  • Optic neuropathy
  • Pernicious anemia
  • Polyneuropathy
  • Regional enteritis
  • Subacute combined degeneration of the spinal cord