Metabolic consequence of vitamin B12 deficiency in the mitochondria

In mitochondria, vitamin B12 deficiency impacts the enzyme L-methylmalonyl-CoA mutase (MUT). This deficiency not only disrupts the biosynthesis of crucial compounds but also triggers the accumulation of reaction intermediates that are potentially toxic at increased concentrations, leading to metabolic decompensation. The light green arrows highlight further biochemical implications resulting from vitamin B12 deficiency, potentially influencing molecular and cellular processes. (Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)