Sleep Disorders
Sleep disorders
Apr. 27, 2024
-
-
Abbreviations: HC, haptocorrin (probably more commonly known as R-protein or transcobalamin I); HCy, homocysteine; MMA, methylmalonic acid; TC, transcobalamin; TC-R, the transcobalamin receptor, CD320; VitB12, vitamin B12.
(Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0. Note this figure was modified by Dr. Douglas J Lanska from the original, which was intended to compare divergent metabolic processes and uptake mechanisms of vitamin B12 across human, mouse, and zebrafish.)
" data-primary-entry="true" x-on:click.stop aria-label="email">
-
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Abstract of the metabolic processes and uptake mechanisms of vitamin B12 in humans
- Download
-
-
Abbreviations: HC, haptocorrin (probably more commonly known as R-protein or transcobalamin I); HCy, homocysteine; MMA, methylmalonic acid; TC, transcobalamin; TC-R, the transcobalamin receptor, CD320; VitB12, vitamin B12.
(Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0. Note this figure was modified by Dr. Douglas J Lanska from the original, which was intended to compare divergent metabolic processes and uptake mechanisms of vitamin B12 across human, mouse, and zebrafish.)
" data-primary-entry="true" x-on:click.stop aria-label="email">
-
The arrows in the "metabolism" part of the figure indicate an increase (if pointing upwards) or a decrease (if pointing downwards) in the metabolite or vitamin B12.
Abbreviations: HC, haptocorrin (probably more commonly known as R-protein or transcobalamin I); HCy, homocysteine; MMA, methylmalonic acid; TC, transcobalamin; TC-R, the transcobalamin receptor, CD320; VitB12, vitamin B12.
(Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0. Note this figure was modified by Dr. Douglas J Lanska from the original, which was intended to compare divergent metabolic processes and uptake mechanisms of vitamin B12 across human, mouse, and zebrafish.)
Related
Article
Related
Media
Associated
Disorders
- Alcohol-tobacco amblyopia
- Cerebral vascular disease
- Dementia
- Depression
- Developmental delay
- Folate deficiency
- Gastric resection
- Glossitis
- Imerslund-Grasbeck syndrome
- Malabsorption
- Megaloblastic anemia
- Myelopathy
- Optic neuropathy
- Pernicious anemia
- Polyneuropathy
- Regional enteritis
- Subacute combined degeneration of the spinal cord