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Osteoperiostitis, ulnar deviation of the middle fingers, and du Bois sign in a patient with congenital syphilis

This image depicts a dorsal view of a patient’s hands, which exhibited signs found in late congenital syphilis due to syphilitic bone disease that included osteoperiostitis, ulnar deviation of the middle fingers, and du Bois sign, which involves a shortening of the little finger. Congenital syphilis occurs when a developing infant within the womb is infected by the spirochete microorganism, Treponema pallidum, as it receives blood by way of the placenta. (Source: Photography by Renelle Woodall, Centers for Disease Control and Prevention, 1969. Public Health Image Library ID# 16750, Centers for Disease Control and Prevention, Atlanta, Georgia. Public domain.)

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Associated Disorders

  • Congenital HIV infection
  • Congenital central nervous system infections
  • Congenital cytomegalovirus infection
  • Congenital herpes virus infection
  • Congenital infections
  • Congenital rubella infection
  • Congenital toxoplasmosis infection
  • Maternal HIV infection
  • Maternal syphilis