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Small cerebral vessel wall in a patient afflicted with CADASIL (electron micrograph)

Electron microscopy reveals the deposition of granular osmiophilic material (arrows) and degeneration of a smooth muscle cell (Sm) in the media of the vessel wall. An endothelial cell (E) is lining the vessel lumen (L). (Contributed by Dr. Steve Moore and Dr. Jill Hagenkord of the University of Iowa Department of Pathology.)

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