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LCMV infection in mouse brain

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In the adult mouse brain, LCMV selectively infects the leptomeninges, choroid plexus, and ventricular ependymal lining, where the virus induces a lymphocytic infiltration. Fifty-micrometer-thick section through the tissues surrounding the lateral (L) and 3rd (III) ventricles immunohistochemically stained for LCMV (panel A) and CD8+ lymphocytes (panel B). The mouse was intracerebrally inoculated with LCMV 4 days previously. [A] The ventricular ependymal lining (arrowheads) and choroid plexus (arrows) are selectively infected with LCMV. Note that neurons of the brain parenchyma within the basal ganglia (BG) and septum (S) are not infected in this mature brain. [B] Numerous CD8+ lymphocytes (arrows) have infiltrated the ependymal lining (E) and choroid plexus (CP). Magnification bars represent 200 um in A and 100 um in B. (Contributed by Dr. Daniel Bonthius.)