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Asymmetric involvement of the arms and hands in a young man with acromegaly

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Note the marked asymmetric involvement of the arms, with the left arm and hand markedly larger than the left. The left index finger has also grown in deformed manner. This is one of a series of five photographs of cases of acromegaly described by German pathologist Rudolf Virchow (1821-1902) in a paper that was read before the Berlin Medical Society on January 16, 1889. (Historic photograph restored by Douglas J Lanska MD. Courtesy of the Wellcome Library. Creative Commons Attribution 4.0 International license [CC BY 4.0].)