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Normal cortical layer organization in sham and loss of any cellular layer organization in exencephaly in mouse model of congenital cranioschisis

Normal cortical layer organization in sham (top row) and loss of any cellular layer organization in exencephaly (bottom row) (left to right in each row: 10x, 20x, and 40x, hematoxylin and eosin). Abbreviations: MZ: marginal zone; CP: cortical plate; SP: sub plate; IZ: intermediate zone. (Source: Oria M, Duru S, Figueira RL, et al. Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis. Cell Death Dis 2019;10[10]:721. Creative Commons Attribution [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)