Developmental Malformations
Norrie disease
Aug. 11, 2024
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Wall-eyed stereo view of ECG modeled into the folate-binding site of human dihydrofolate reductase
Wall-eyed stereo view of ECG modeled into the folate-binding site of human dihydrofolate reductase (DHFR). Abbreviations: ECG: (-)-epicatechin gallate; DHFR: dihydrofolate reductase. Carbon atoms of the ECG ligand and surrounding protein are colored green and grey, respectively. Residue Phe-31, located behind the ECG, is unlabeled. Four different ligands from human and chicken DHFR crystal structures were used to define a binding envelope, shown in cyan. These were placed in a common orientation by superimposing backbone atoms from a common set of protein residues located around the ligands. (Source: Sanchez-del-Campo L, Sáez-Ayala M, Chazarra S, Cabezas-Herrera J, Rodríguez-López JN. Binding of natural and synthetic polyphenols to human dihydrofolate reductase. Int J Mol Sci 2009;10[12]:5398-410. Creative Commons Attribution [CC BY 3.0] license, creativecommons.org/licenses/by/3.0.)