General Neurology
Coma due to supratentorial and cerebellar lesions
Aug. 06, 2024
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Blockade of tetrodotoxin-sensitive voltage-gated sodium channels
The normal condition is depicted in the top image, and the tetrodotoxin blockade (black blobs on the outer surface of the voltage-gated sodium channels) is depicted in the lower image. TTX=tetrodotoxin. (Source: Campos-RÃos A, Rueda-Ruzafa L, Herrera-Pérez S, Rivas-RamÃrez P, Lamas JA. Tetrodotoxin: a new strategy to treat visceral pain? Toxins (Basel) 2021;13[7]:496. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0. This figure was modified and edited by Dr. Douglas J Lanska; the original emphasis on pain transmission in bipolar sensory neurons was changed to schematically depict a generic neuron.)