Neuromuscular Disorders
Peripheral nerve hyperexcitability syndromes
May. 13, 2024
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Eukaryotic voltage-gated sodium channels and the outer pore blockers: general 3D model of sodium channels
Positions of toxin-interacting residues are shown by red circles. In eukaryotic voltage-gated sodium channels, the selectivity filter DEKA ring, which contains D, E, K, and A residues, borders the extracellularly exposed outer pore and the inner pore that is exposed to the cytoplasm in the open channel. Abbreviations: TTX (tetrodotoxin), STX (saxitoxin), and μ-CTX (μ-conotoxin). (Source: Tikhonov DB, Zhorov BS. Predicting structural details of the sodium channel pore basing on animal toxin studies. Front Pharmacol 2018;9:880. Creative Commons Attribution [CC BY] license.)