Stroke & Vascular Disorders
Fibromuscular dysplasia
Apr. 21, 2022
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Coupled movement of a sodium ion and ligand QX-222 in the closed cardiac sodium channel (3)
A μ-conotoxin (μ-CTX) mutant does not completely block the sodium current. The sodium ion can escape through the incompletely sealed outer pore and vacate the cation-attractive central cavity for binding of QX-222, which is a lidocaine derivative and a sodium channel blocker. (Source: Tikhonov DB, Zhorov BS. Predicting structural details of the sodium channel pore basing on animal toxin studies. Front Pharmacol 2018;9:880. See also: Bruhova I, Tikhonov DB, Zhorov BS. Access and binding of local anesthetics in the closed sodium channel. Mol Pharmacol 2008;74[4]:1033-45. Creative Commons Attribution [CC BY] license.)