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Red-purple, nonblanching vascular skin lesions (angiokeratoma) on the umbilicus of a patient with Fabry disease

Angiokeratoma are usually distributed on the buttocks, groin, umbilicus, upper thighs (bathing trunk distribution), and, occasionally, on the lips and oral mucosa. (Source: Burlina AP, Sims KB, Politei JM, et al. Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel. BMC Neurol 2011;11:61.)

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