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Relationship between glucocerebrosidase (GCase) and neurologic diseases with Lewy bodies (1)

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Normally, GCase interacts with its substrate glucosylceramiide (GlcCer) as well as monomers of alpha-synuclein in lysosomes, facilitating the breakdown of both at acidic pH. (Source: Stirnemann J, Belmatoug N, Camou F, et al. A review of Gaucher disease pathophysiology, clinical presentation, and treatments. Int J Mol Sci 2017;18[2]:441. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)