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Scheme of the rate-limiting step of MAO-catalyzed serotonin degradation

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Scheme of the rate-limiting step of MAO-catalyzed serotonin degradation, involving a hydride transfer between the reacting carbon atom of serotonin (SRO) vicinal to the amino group, to the nitrogen atom of the flavin adenine dinucleotide (FAD) cofactor inside the MAO active site. (Source: Prah A, Pregeljc D, Stare J, Mavri J. Brunner syndrome caused by point mutation explained by multiscale simulation of enzyme reaction. Sci Rep 2022;12[1]:21889. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)