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Hemoglobin dissociation curve from the 1911 Anglo-American Expedition to Pikes Peak

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The continuous line represents the dissociation curve of oxyhemoglobin in the blood of British physiologist Claude Gordon Douglas (1882-1963) and John Scott Haldane, determined in Oxford in the presence of 40 mm pressure of CO2 at 38°C. The determinations made on Pikes Peak at 38° are indicated as follows: blood of Douglas and Haldane, respectively, in the presence of 28 mm pressure of CO2 (open and closed circles); blood of Douglas and Haldane, respectively, in the presence of 41 mm pressure of CO2 (x and +). (Source: Douglas CG, Haldane JS, Henderson Y, Schneider EC. Physiological observations made on Pike's Peak, Colorado, with special reference to adaptation to low barometric pressures. Philosophical Transactions of the Royal Society, Series A 1913;203:185-318.)