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Alveolar CO2 and O2 pressures as a function of altitude from the 1911 Anglo-American Expedition to Pikes Peak

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(Thick line) alveolar CO2 pressure; (thin line) alveolar O2 pressure; (horizontal interrupted lines) mean normal alveolar and oxygen pressures at sea level (ie, Oxford and New Haven, Connecticut). Measurements for Claude Gordon Douglas are shown. Those for the other members of the expedition were similar. (Source: Douglas CG, Haldane JS, Henderson Y, Schneider EC. Physiological observations made on Pike's Peak, Colorado, with special reference to adaptation to low barometric pressures. Philosophical Transactions of the Royal Society, Series A 1913;203:185-318.)