This is an image preview.
Start a Free Account
to view the full image.

Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Listen to MedLink on the go with Audio versions of each article.

Tumor-induced osteomalacia diagnostic algorithm

Download

Legend: 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin D; ALP, alkaline phosphatase; FGF23, fibroblast growth factor 23; PTH, parathyroid hormone. (a) Perform genetic testing before imaging in children, young adults, or those with suggestive family history. (b) Perform genetic testing in adults without family history and negative functional imaging. (Source: Jan de Beur SM, Minisola S, Xia WB, et al. Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia. J Intern Med 2023;293[3]:309-28.)

Figure adapted from:
Minisola S, Peacock M, Fukumoto S, et al. Tumour-induced osteomalacia. Nat Rev Dis Primers 2017;3:17044.
Courbebaisse M, Lanske B. Biology of fibroblast growth factor 23: from physiology to pathology. Cold Spring Harb Perspect Med 2018;8[5]:a031260.
Saraff V, Nadar R, Högler W. New Developments in the treatment of X-linked hypophosphataemia: implications for clinical management. Paediatr Drugs 2020;22[2]:113-21. Creative Commons Attribution [CC-BY] license, creativecommons.org/licenses/by/2.0.)