Epilepsy & Seizures
Lafora disease
May. 31, 2024
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ISSN: 2831-9125
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
Nearly 3,000 illustrations, including video clips of neurologic disorders.
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MRI of a patient with PLPHP deficiency at 4.5 years of age. A sagittal T1-weighted image (A) demonstrates a thin corpus callosum. Axial views show patchy bilateral increase in T2 (B) and FLAIR (C, D) signal in the deep white matter around the ventricles, especially in the frontal and peritrigonal regions. There is marked cerebral atrophy with prominent CSF spaces, particularly over frontal and Sylvian regions bilaterally (ie, predominant frontotemporal atrophy). (Source: Alsubhi S, Osterman B, Chrestian N, Dubeau F, Buhas D, Srour M. Case report: PLPHP deficiency, a rare but important cause of B6-responsive disorders: a report of three novel individuals and review of 51 cases. Front Neurol 2022;13:913652. Creative Commons Attribution License [CC BY], creativecommons.org/licenses/by/4.0.)