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Difference between a normal control rat and the vacuolization of pyramidal neurons in the CA3 region of a rat treated with domoic acid

(Left) CA3 region of the hippocampus of a control rat showing good preservation and integrity of the neuropil. Mitochondria (M), synaptic spines (arrow) and dendrites (D) are identified. Scale Bar = x1.1μm. (Right) CA3 region of the hippocampus of a rat treated by gavage with domoic acid for 64 days. Vacuoles (V) and the "Swiss cheese" effect are more apparent at this magnification. Some remaining dendritic spines (arrow) can still be identified. There is increased electron density of the mitochondria (M) with loss of organization of the cristae. Scale Bar = x1.1μm. (Source: Pulido 2008. Creative Commons Attribution license. http://creativecommons.org/licenses/by/3.0.)

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