Neurobehavioral & Cognitive Disorders
Limbic-predominant age-related TDP-43 encephalopathy (LATE)
Jun. 17, 2024
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Difference between a normal control and the marked astrocytosis in a monkey treated with domoic acid
Brains of monkeys (Macaca fascicularis, the crab-eating macaque). Histological sections were processed for GFAP immunohistochemistry. (Left) Hippocampus of a control monkey showing the granular cell layer (GL) of the dentate gyrus and the CA4 region with spaced astrocytes labeled by glial fibrillary acidic protein (GFAP) immunohistochemistry. Some immunolabeled astrocytes are clearly identified around blood vessels (arrow). Objective x10. (Right) Hippocampus of a monkey treated with a single intravenous dose of domoic acid. The initial symptoms of toxicity lasted 90 minutes and included vomiting, gagging, lethargy, and disorientation. Necropsy was conducted 6 months after the injection. Sections show marked astrocytosis as revealed by the intensity of the GFAP immunohistochemical staining seen in CA4 and the subgranular zone (arrow); granular cell layer (GL). Objective x20. (Source: Pulido 2008. Creative Commons Attribution license. http://creativecommons.org/licenses/by/3.0.)