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Structure of dimeric West Nile virus nonstructural protein 1 (NS1), top view

One monomer is gray, and one is color coded by domain (blue, b-roll; yellow, wing; red, b-ladder; and salmon, spaghetti loop). The disordered flexible loop is indicated by orange dashed lines. (Source: Wessel AW, Doyle MP, Engdahl TB, Rodriguez J, Crowe JE Jr, Diamond MS. Human monoclonal antibodies against NS1 protein protect against lethal West Nile virus infection. mBio 2021;12[5]:e0244021. Creative Commons Attribution 4.0 International License, https://creativecommons.org/licenses/by/4.0.)

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  • Encephalitis
  • Meningitis
  • Meningoencephalitis
  • Poliomyelitis