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Transport of thiamine from the blood to the cell

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Abbreviations: α-KGDH, alpha-ketoglutarate dehydrogenase; BCAKDH, branched chain alpha-keto acid dehydrogenase; HOACol, 2-hydroxyacyl CoA lyase 1; OCT, organic cation transporter; PDHG, pyruvate dehydrogenase; RFC, reduced folate carrier; T+, free thiamine; TDP, thiamine diphosphate; ThTR, thiamine transporter; TK, thiamine kinase; TMP, thiamine monophosphate; TPC, mitochondrial thiamine pyrophosphate carrier; TTP, thiamine triphosphate. (Source: Ott M, Werneke U. Wernicke's encephalopathy: from basic science to clinical practice. Part 1: Understanding the role of thiamine. Ther Adv Psychopharmacol 2020;10:2045125320978106. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)