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Nemaline myopathy (electron micrograph)

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A longitudinal section of normal muscle fiber, with intact sarcomeric structure, is flanked by one showing myofibrillar disruption and aggregates of material. These aggregates have the same electron density and periodicity as Z-bands, and appear as rod-shaped inclusions with long axes in the same direction as the axis of the myofibrils. (x17,000) (Contributed by Dr. Susan Iannaccone.)