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Resolving hyperintensity in the hand knob area in osmotic demyelination syndrome (axial FLAIR)

Axial FLAIR sequence 6 months after symptom onset in osmotic demyelination syndrome showing resolving hyperintensity in the hand knob area. (Source: Siranart N, Nakaphan P, Viarasilpa V, Anukoolwittaya P, Hemachudha P. Hand knob sign in osmotic demyelinating syndrome. BMC Neurol 2024;24[1]:83. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

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Associated Disorders

  • Alcoholism
  • Extrapontine myelinolysis
  • Hyperosmolar hyperglycemic state
  • Hypokalemia
  • Malnutrition
  • Osmotic myelinolysis