Neurobehavioral & Cognitive Disorders
Subcortical vascular cognitive impairment
Jul. 06, 2024
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Serial cross-sections of muscle from a patient with Kearns-Sayre syndrome
(A) The modified Gomori trichrome stain shows fibers with purplish patches representing abnormal accumulations of mitochondria. These are known as “ragged-red fibers” (RRF). (B) The succinate dehydrogenase (SDH) stain better reveals the abnormal proliferation of mitochondria as excessively stained fibers corresponding to RRF. These fibers are labeled “ragged-blue.” (C) The cytochrome c oxidase (COX) stain shows complete or partial loss of the normal brown color in ragged-red or ragged-blue fibers. These are COX-negative or COX-deficient fibers. (D) When the SDH and COX stainings are superimposed, COX-negative and COX-deficient fibers appear blue, while in normal fibers the brown COX stain prevails. (Contributed by Dr. Salvatore DiMauro.)