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mTor pathway

Features of signaling through the mammalian target of rapamycin complex 1 pathway via the tuberous sclerosis 1/tuberous sclerosis 2 complex. eIF4B, eukaryotic translation initiation factor 4B; eIF4E, eukaryotic translation initiation factor 4E; eIF4G, eukaryotic translation initiation factor 4G; GDP, guanosine diphosphate; GTP, guanosine triphosphate; mTORC1, mammalian target of rapamycin complex 1; Rheb, Ras homologue enriched in the brain; S6, ribosomal protein S6; S6K1, ribosomal protein S6.kinase 1; TSC1, tuberous sclerosis complex 1 protein; TSC2, tuberous sclerosis complex 2 protein; 4EBP1, eukaryotic translation initiation factor 4E binding protein 1. (Contributed by Dr. Hema Murali.)

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Associated Disorders

  • Agenesis of the corpus callosum
  • Klippel-Trénaunay syndrome
  • Neurofibromatosis