Harmonized framework used to establish a deafferentation model applicable to Bonnet syndrome

The functional mechanism under deafferentation (ie, blindness in this context) is that false sensory data become overly influential, overriding the results of data comparison and expectancies to become incorporated into a hallucinatory perception. The hallucinated perception is replaced by a veridical one when the strength of the false sensory evidence reduces, or expectancies and data comparison override it. False sensory data results from hyperexcitability and spontaneous activation of the primary visual cortex caused by chronic loss of visual input. Green shading indicates which aspects of the framework are mapped to in each model, with the green text indicating the specific effects on functions. (Source: Collerton D, Barnes J, Diederich NJ, et al. Understanding visual hallucinations: a new synthesis. Neurosci Biobehav Rev 2023;150:105208. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)