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Multimodal imaging of the eye in multifocal chorioretinitis due to acute West Nile virus infection

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(A) In the right eye, fluorescein angiography showed hyperfluorescent lesions with a linear distribution, corresponding to the hypocyanescent lesions in indocyanine green angiography (ICGA). (B) In the left eye, fundus autofluorescence showed vitreitis, whereas optical coherence tomography showed the presence of hyperreflective dots in the vitreous chamber, hyperreflective oval deposits on the retinal surface, focal alteration in the retinal pigmented epithelium and the ellipsoid zone, and granular hyperreflective specks located predominantly in the outer and inner nuclear layers. (C) In the right eye, fundus autofluorescence showed hyperautofluorescent lesions with a linear distribution, corresponding to focal alteration in the retinal pigmented epithelium and the ellipsoid zone visualized with optical coherence tomography. (D) In the left eye, fluorescein angiography showed “target” lesions with a rim of hyperfluorescence and a central spot of hypofluorescence, corresponding to focal alteration of the retinal pigmented epithelium and the ellipsoid zone. (Source: Valsecchi N, Veronese C, Roda M, Ciardella AP, Fontana L. Bilateral multifocal chorioretinitis as the only presentation of acute West Nile virus infection: a case report. BMC Ophthalmol 2024;24[1]:160. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)