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Gross brain atrophy in Alzheimer disease

Coronal section of cerebral hemispheres in a 65-year-old male with Alzheimer disease. Notice diffuse cerebral atrophy evidenced by widened subarachnoid spaces and dilatation of lateral ventricles and temporal horns. Notice atrophy of the hippocampal gyrus. (Contributed by Dr. David Geldmacher.)

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