Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

Sign Up for a Free Account For information on discounts, see Plans & Pricing

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Chemical biology in ALS-FTD

The interaction between dipeptide repeat polypeptides (DPRs), tethering of mitochondria to the endoplasmic reticulum by the VAPB-PTPIP51 tethering proteins, calcium and glycogen synthase beta gene (GSK-3b), resulting in impaired synaptic function and neurodegeneration in C9orf72 mutations ALS-FTD. (Contributed by Dr. Peter K Panegyre.)

Related Article

Related Media

Associated Disorders

  • Alzheimer disease
  • Creutzfeldt-Jakob disease
  • Familial amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Pick disease