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Nasal biopsy histology in granulomatosis with polyangiitis causing cavernous sinus syndrome and diabetes insipidus

Histopathology of a nasal biopsy in a woman with granulomatosis with polyangiitis causing cavernous sinus syndrome and diabetes insipidus (H&E stain, magnification X100). This condition was formerly called Wegener granulomatosis. Vertical arrows show granuloma. Horizontal left-facing arrow: necrosis. Horizontal right-facing arrow: angiitis with necrosis in vessel wall.

(Source: Peters JE, Gupta V, Saeed IT, Offiah C, Jawad AS. Severe localised granulomatosis with polyangiitis [Wegener's granulomatosis] manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review. BMC Neurol 2018;18[1]:59. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)