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Metabolic consequence of vitamin B12 deficiency in the cytoplasm

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In the cytoplasm, vitamin B12 deficiency impacts the enzyme methionine synthase (MTR). This deficiency not only disrupts the biosynthesis of crucial compounds but also triggers the accumulation of reaction intermediates that are potentially toxic at increased concentrations, leading to metabolic decompensation. Lightning bolt icons indicate the metabolic steps that might indirectly contribute to oxidative stress. The light green arrows highlight further biochemical implications resulting from vitamin B12 deficiency, potentially influencing molecular and cellular processes. (Source: Mathew AR, Di Matteo G, La Rosa P, et al. Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms. Int J Mol Sci 2024;25[1]:590. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)