Neuropharmacology & Neurotherapeutics
Memantine
Jun. 04, 2021
MedLink®, LLC
3525 Del Mar Heights Rd, Ste 304
San Diego, CA 92130-2122
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
Nearly 3,000 illustrations, including video clips of neurologic disorders.
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
Full spectrum of neurology in 1,200 comprehensive articles.
Listen to MedLink on the go with Audio versions of each article.
The N-terminal domain (NTD) region contains the mitochondrial targeting sequence. The thumb subdomains (T) of the protein are located between the exonuclease and linker region, as well as within the polymerase region. The exonuclease domain contains essential sequence motifs I, II, and III for its activity. The polymerase domain contains subdomains comprising the thumb (T), palm, and finger, which contain motifs A, B, and C. Two regions comprise the palm subdomain within the polymerase domain, and those motifs located within the polymerase domain are critical for polymerase activity. Arrows indicate the numbered positions of amino acids that begin a subdomain. (Contributed by Dr. Bruce H Cohen.)