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Clinical features of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS)

Data presented as overall prevalence. All patients with CANVAS experienced more than one symptom. *Based on nerve conduction studies. (Source: Turner RD, Hirons B, Cortese A, Birring SS. Chronic cough as a genetic neurological disorder? Insights from cerebellar ataxia with neuropathy and vestibular areflexia syndrome [CANVAS]. Lung 2023;201[6]:511-19. Adapted from: Cortese A, Tozza S, Yau WY, et al. Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion. Brain 2020;143[2]:480-90. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0.)

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  • Insidious symmetric bilateral vestibulopathy
  • Sequential unilateral vestibulopathy