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Cerebral amyloid angiopathy associated with chronic granulomatous arteritis

Meningeal vessel shows severe transmural chronic inflammation, including multinucleated (foreign body type) giant cells that surround amyloid beta protein (Aß) immunoreactive material. One interpretation of this finding is that the giant cells recognize the Aß amyloid as a “foreign” protein. (Contributed by Dr. Jeffrey L Saver.)

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Associated Disorders

  • Alzheimer disease
  • Arteriovenous malformations
  • CAA
  • Cavernous hemangiomas
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
  • Cerebral venous thrombosis
  • Chronic traumatic encephalopathy
  • Coagulopathies
  • Dementia with Lewy bodies
  • Diffuse arteriosclerosis
  • Down syndrome
  • Fabry disease
  • Fibromuscular dysplasia
  • Hemorrhage into cerebral neoplasms
  • Hypertensive hemorrhage
  • Hypertensive vasculopathy
  • Infratentorial superficial siderosis
  • Intracerebral hemorrhage
  • Ischemic stroke
  • Leukoaraiosis
  • Lobar hemorrhage
  • Malignant hypertension
  • Malignant neoplasms and radiation necrosis
  • Memory loss
  • Moyamoya disease
  • Mycotic aneurysms
  • Nontraumatic intracerebral hemorrhage
  • Other dementias
  • Primary CNS angiitis
  • Prion disease
  • Seizures
  • Superficial siderosis
  • Trauma
  • VCID
  • Vascular cognitive impairment and dementia
  • Vasculitis