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Abnormal oligodendrocytes and macrophages

Light microscopy of toluidine blue thick sections of plastic embedded glutaraldehyde fixed tissue (400 magnification). (Arrow) Foamy oligodendroglial cell with abundant fine foamy to granular cytoplasm. Note the undefined borders of the oligodendroglial cell and close association with adjacent axons. (Large arrowhead) Macrophage containing cytoplasmic lysosomes in the same field. (Small arrowhead) Cellular debris is being engulfed by macrophage. (Contributed by Dr. Raphael Schiffmann.)