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Large oligodendroglial-like cell in childhood ataxia with central nervous system hypomyelination

Light microscopy (400 original magnification) of myelin oligodendrocyte glycoprotein (oligodendrocyte marker) antibody immunoperoxidase-labeled foamy oligodendroglial cell. The enormous cell volume pushes the small, oval nucleus to an eccentric location. Cell diameter is 40 microns, which is larger than a large pyramidal neuron. Occasionally, macrophages may become this large, but they are usually multinucleated. (Contributed by Dr. Raphael Schiffmann.)