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Neonate brains (basal views)

Basal views of brain of 2 neonates at autopsy, after 2 weeks of formalin fixation. The one on the left (NA90/84) has global cerebellar hypoplasia. The one on the right (A36/84) is a normal, age-matched control. The brainstems and cerebral hemispheres appear externally normal in both. There is a thin layer of subarachnoid blood in the leptomeninges of A36/84, giving it a darker appearance; this is, though, unrelated to the cerebellar hypoplasia. Note the difference in the lateral extension of the cerebellar hemispheres in the two brains. (Contributed by Dr. Harvey Sarnat.)

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Associated Disorders

  • Chiari malformation
  • Chromosomal disorders
  • Congenital disorders of glycosylation
  • Dandy-Walker malformation
  • Fragile X syndrome
  • Global cerebellar hypoplasia
  • Granuloprival cerebellar hypoplasia
  • Holoprosencephaly
  • Joubert syndrome
  • Lissencephaly/pachygyria
  • Macrocerebellum
  • Meckel-Grüber syndrome
  • Meningomyelocele
  • Menkes kinky hair disease
  • Midbrain agenesis
  • Miller-Dieker syndrome
  • Rett syndrome
  • Rhombencephalosynapsis
  • Selective hypoplasia of the cerebellar vermis
  • Septo-optic-pituitary dysplasia
  • Subcortical band heterotopia
  • Total aplasia of the cerebellum
  • Trisomy 13-15
  • Trisomy 16-18
  • VLDLR-associated pontocerebellar hypoplasia
  • Walker-Warburg syndrome